N,N-dioctadecyldiglycolic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-dioctadecyldiglycolic acid
• 英文别名: N,N-dioctadecyl-3-oxaglutaramide；2-[2-(Dioctadecylamino)-2-oxoethoxy]acetamide
• 化学式: C₄₀H₈₀N₂O₃
• 分子量: 637.087
• InChiKey: XMQGWLCRRKKBCV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  16.2
• 重原子数：
  45
• 可旋转键数：
  38
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  72.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N,N-dioctadecyldiglycolic acid 在 sodium 、 N,N'-羰基二咪唑 作用下， 以 氯仿 、 二甲基亚砜 为溶剂， 反应 10.0h， 生成 5-[3-(2-{2-[2-(2-Dioctadecylcarbamoylmethoxy-acetylamino)-ethoxy]-ethoxy}-ethyl)-thioureido]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)-benzoic acid
  参考文献：
  名称：

  Investigation of Specific Binding of Antifluorescyl Antibody and Fab to Fluorescein Lipids in Langmuir-Blodgett Deposited Films Using Quartz Crystal Microbalance Methodology

  摘要：

  Antifluorescyl IgG antibody and Fab binding to two fluorescein-conjugated lipids was measured using the quartz crystal microbalance methodology. By use of the Langmuir-Blodgett technique, the fluorescein lipids, which were diluted to 5% in a L-alpha-dipalmitoyl phosphatidylethanolamine (DPPE) matrix, were deposited directly onto one gold electrode of the quartz crystal. Binding to films containing the fluorescein hapten was significantly enhanced compared to films of the pure DPPE matrix lipid, indicating that binding occurred primarily through a specific interaction. Association constants were 40-300 times less than for binding to haptens free in solution. Binding of IgG to the lipid in which the hydrocarbon chains and the fluorescein hapten were linked via a hydrophilic spacer was similar to 7 times as great as to the lipid containing no spacer. IgG binding to the lipid containing the spacer was increased 1.5-4.4 times compared to Fab binding for the same lipid. Equilibrium binding curves and kinetic measurements are analyzed quantitatively and compared.

  DOI：

  10.1021/ac00082a014
• 作为产物：
  描述：

  二甘醇酐 、 双十八烷基胺 以 甲苯 为溶剂， 反应 48.0h， 以87%的产率得到N,N-dioctadecyldiglycolic acid
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS FOR SYNTHETIC AMPHIPHILE-INDUCED CHANGES IN PLANT ROOT MORPHOLOGY
  [FR] COMPOSITIONS ET PROCÉDÉS POUR MODIFICATIONS DE MORPHOLOGIE DE RACINES DE PLANTE INDUITES PAR AMPHIPHILE SYNTHÉTIQUE

  摘要：

  该公开提供了一种通过将植物暴露在含有合成两性分子的组合物中来增加植物侧根发育的方法。通过增加侧根的数量，根结构的表面积增加，使植物更能够抵抗干旱或低营养等压力。

  公开号：

  WO2016022991A1

文献信息

• Compositions and methods for synthetic amphiphile-induced changes in plant root morphology
  申请人：The Curators of the University of Missouri

  公开号：US10548319B2

  公开（公告）日：2020-02-04

  The disclosure provides a method for increasing the lateral root development of a plant by exposing said plant to a composition containing a synthetic amphiphile. By increasing the number of lateral roots, the surface area of the root structure is increased, making the plants better able to survive such stresses as drought or low nutrients.

  本公开提供了一种通过将植物暴露于含有合成双亲化合物的组合物来增加植物侧根发育的方法。通过增加侧根的数量，根部结构的表面积增大，使植物更能在干旱或低养分等压力下存活。
• Compositions and Methods for Synthetic Amphiphile-Induced Changes in Plant Root Morphology
  申请人：The Curators of the University of Missouri

  公开号：US20180077933A1

  公开（公告）日：2018-03-22

  The disclosure provides a method for increasing the lateral root development of a plant by exposing said plant to a composition containing a synthetic amphiphile. By increasing the number of lateral roots, the surface area of the root structure is increased, making the plants better able to survive such stresses as drought or low nutrients
• [EN] COMPOSITIONS AND METHODS FOR SYNTHETIC AMPHIPHILE-INDUCED CHANGES IN PLANT ROOT MORPHOLOGY<br/>[FR] COMPOSITIONS ET PROCÉDÉS POUR MODIFICATIONS DE MORPHOLOGIE DE RACINES DE PLANTE INDUITES PAR AMPHIPHILE SYNTHÉTIQUE
  申请人：UNIV MISSOURI

  公开号：WO2016022991A1

  公开（公告）日：2016-02-11

  The disclosure provides a method for increasing the lateral root development of a plant by exposing said plant to a composition containing a synthetic amphiphile. By increasing the number of lateral roots, the surface area of the root structure is increased, making the plants better able to survive such stresses as drought or low nutrients

  该公开提供了一种通过将植物暴露在含有合成两性分子的组合物中来增加植物侧根发育的方法。通过增加侧根的数量，根结构的表面积增加，使植物更能够抵抗干旱或低营养等压力。
• Investigation of Specific Binding of Antifluorescyl Antibody and Fab to Fluorescein Lipids in Langmuir-Blodgett Deposited Films Using Quartz Crystal Microbalance Methodology
  作者：Hiroshi. Ebato、Christine A. Gentry、James N. Herron、Wolfgang. Mueller、Yoshio. Okahata、Helmut. Ringsdorf、Peter A. Suci

  DOI：10.1021/ac00082a014

  日期：1994.5.15

  Antifluorescyl IgG antibody and Fab binding to two fluorescein-conjugated lipids was measured using the quartz crystal microbalance methodology. By use of the Langmuir-Blodgett technique, the fluorescein lipids, which were diluted to 5% in a L-alpha-dipalmitoyl phosphatidylethanolamine (DPPE) matrix, were deposited directly onto one gold electrode of the quartz crystal. Binding to films containing the fluorescein hapten was significantly enhanced compared to films of the pure DPPE matrix lipid, indicating that binding occurred primarily through a specific interaction. Association constants were 40-300 times less than for binding to haptens free in solution. Binding of IgG to the lipid in which the hydrocarbon chains and the fluorescein hapten were linked via a hydrophilic spacer was similar to 7 times as great as to the lipid containing no spacer. IgG binding to the lipid containing the spacer was increased 1.5-4.4 times compared to Fab binding for the same lipid. Equilibrium binding curves and kinetic measurements are analyzed quantitatively and compared.