2-chloro-4-(cyclopropylethynyl)pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 2-chloro-4-(cyclopropylethynyl)pyrimidine
• 英文别名: 2-chloro-4-(2-cyclopropylethynyl)pyrimidine；2-Chloro-4-(2-cyclopropylethynyl)pyrimidine
• 化学式: C₉H₇ClN₂
• 分子量: 178.621
• InChiKey: RODSHBGZEBCRMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-chloro-4-(cyclopropylethynyl)pyrimidine 在 碳酸氢钠 、 hydroxylamine-O-sulfonic acid 作用下， 以 水 、 正丁醇 为溶剂， 反应 44.0h， 生成 4-((4-(2-cyclopropyl-6-methoxypyrazolo[1,5-b]pyridazin-3-yl)pyrimidin-2-yl)amino)cyclohexan-1-ol
  参考文献：
  名称：

  Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-b]pyridazines for the Treatment of Human African Trypanosomiasis

  摘要：

  From a high-throughput screen of 42 444 known human kinases inhibitors, a pyrazolo[1,5-b]pyridazine scaffold was identified to begin optimization for the treatment of human African trypanosomiasis. Previously reported data for analogous compounds against human kinases GSK-3 beta, CDK-2, and CDK-4 were leveraged to try to improve the selectivity of the series, resulting in 23a which showed selectivity for T. b. brucei over these three human enzymes. In parallel, properties known to influence the absorption, distribution, metabolism, and excretion (ADME) profile of the series were optimized resulting in 20g being progressed into an efficacy study in mice. Though 20g showed toxicity in mice, it also demonstrated CNS penetration in a PK study and significant reduction of parasitemia in four out of the six mice.

  DOI：

  10.1021/acs.jmedchem.9b01741
• 作为产物：
  描述：

  2,4-二氯嘧啶 、 环丙乙炔 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 三乙胺 作用下， 以 四氢呋喃 为溶剂， 以380 mg的产率得到2-chloro-4-(cyclopropylethynyl)pyrimidine
  参考文献：
  名称：

  CN116854678

  摘要：

  公开号：