前列腺素F2alphaN-二甲基酰胺 | 67508-08-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 前列腺素F2alphaN-二甲基酰胺
• 英文名称: PGF_2α dimethylamide
• 英文别名: PGF2alpha dimethyl amide；prostaglandin F2α dimethylamide；(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]-N,N-dimethylhept-5-enamide
• CAS: 67508-08-1
• 化学式: C₂₂H₃₉NO₄
• 分子量: 381.556
• InChiKey: QGAWKBHDDFBNMX-GWSKAPOCSA-N

物化性质

• 沸点：
  529.4±50.0 °C(Predicted)
• 密度：
  1.089±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  27
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  81
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  在 盐酸 、 水 作用下， 以 甲醇 为溶剂， 反应 0.33h， 以34.9 mg的产率得到前列腺素F2alphaN-二甲基酰胺
  参考文献：
  名称：

  Prostaglandin fluorides in synthesis of natural prostaglandin derivatives at carboxyl group

  摘要：

  Methods of synthesis of prostaglandin fluorides were developed and their properties were investigated. These compounds were shown to be convenient synthetic precursors for obtaining esters and amides of natural prostaglandins and their fluorodeoxy analogues.

  DOI：

  10.1134/s1068162009010142

文献信息

• NOVEL PROSTAMIDES FOR THE TREATMENT OF GLAUCOMA AND RELATED DISEASES
  申请人：Allergan, Inc.

  公开号：US20140107124A1

  公开（公告）日：2014-04-17

  Disclosed herein are compositions comprising an amide related to a prostaglandin and a biogenic amine. Other aspects relate to certain chemical compounds, pharmaceutical compositions, and methods of treating glaucoma.

  本文披露了一种含有与前列腺素相关的酰胺和生物胺的组合物。其他方面涉及某些化学化合物、药物组成物和治疗青光眼的方法。
• US8648213B2
  申请人：——

  公开号：US8648213B2

  公开（公告）日：2014-02-11
• US9433627B2
  申请人：——

  公开号：US9433627B2

  公开（公告）日：2016-09-06
• Prostaglandin fluorides in synthesis of natural prostaglandin derivatives at carboxyl group
  作者：I. V. Serkov、V. V. Bezuglov

  DOI：10.1134/s1068162009010142

  日期：2009.1

  Methods of synthesis of prostaglandin fluorides were developed and their properties were investigated. These compounds were shown to be convenient synthetic precursors for obtaining esters and amides of natural prostaglandins and their fluorodeoxy analogues.