myristoic acid chloride

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: myristoic acid chloride
• 英文别名: Tetradecanoic acid;hydrochloride；tetradecanoic acid;hydrochloride
• 化学式: C₁₄H₂₈O₂*ClH
• 分子量: 264.836
• InChiKey: LKWYTUHHMNCZEQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.19
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  37.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  myristoic acid chloride 、 ethyl potassium malonate 在 三乙胺 、 magnesium chloride 作用下， 以 乙腈 为溶剂， 以89%的产率得到ethyl 3-oxohexadecanoate
  参考文献：
  名称：

  The influence of ethylene glycol chains on the thermodynamics of hydrogen-bonded supramolecular assemblies in apolar solvents

  摘要：

  用乙二醇链替代氢键导向的超分子组装会导致在非极性溶剂中结合常数的降低，而结合常数的降低则依赖于连接氢键和乙二醇链的脂肪族连接体的长度。

  DOI：

  10.1039/b806506c

文献信息

• Prodrugs of antidepressants and their use for treating depressions
  申请人：——

  公开号：US20040242594A1

  公开（公告）日：2004-12-02

  This invention relates to prodrugs of antidepressants and the use of these prodrugs in a method for therapy and to pharmaceutical compositions comprising the prodrugs of the invention.

  本发明涉及抗抑郁药的前药及其在治疗方法中的使用，以及包含本发明的前药的制药组合物。
• Detergent composition
  申请人：Kao Corporation

  公开号：EP0248294A2

  公开（公告）日：1987-12-09

  Novel detergent composition comprises one or more of N-acyl-N-hydroxyalkylglycines of the general formula (I) or salts thereof: The composition has a very good resistance to hard water, low stimulativeness, and good detergency. It is thus suitably employed as shampoo for babies, kitchen detergent and the like.

  新型洗涤剂组合物包含一种或多种通式（I）的 N-酰基-N-羟基烷基甘氨酸或其盐： 该组合物具有很好的耐硬水性、低刺激性和良好的去污力。因此，它适合用作婴儿洗发水、厨房洗涤剂等。
• Polycarbonate resin composition for radiation sterilization
  申请人：MITSUBISHI GAS CHEMICAL COMPANY, INC.

  公开号：EP0376289A2

  公开（公告）日：1990-07-04

  A polycarbonate resin composition for radiation sterilization, comprising an aromatic polycarbonate resin having structural units derived from a halogenated bisphenol, and a polyalkylene compound selected from poly(alkylene glycol), its ether, silyl ether or ester. Molded articles produced from the composition do not substantially undergo yellowing when exposed to radiation in air or under substantially oxygen-free atmosphere, and can be advantageously employed in medical appliances.

  一种用于辐射灭菌的聚碳酸酯树脂组合物，由芳香族聚碳酸酯树脂（其结构单元来自卤代双苯酚）和聚亚烷基化合物（选自聚（亚烷基二醇）、其醚、硅烷基醚或酯）组成。由该组合物制成的模制件在空气中或基本无氧的环境中暴露于辐射时基本上不会变黄，因此可以很好地应用于医疗器械中。
• Improved leveling aqueous coating compositions
  申请人：AQUALON COMPANY

  公开号：EP0566911A1

  公开（公告）日：1993-10-27

  Hydrophobically modified polysaccharide and synthetic polymers with molecular weights of 10,000 to 300,000 serve as associative thickeners in aqueous protective coatings to (-NORTH-)eveling without adversely affecting sag or thickening efficiency. Hydrophobically modified hydroxyethylcellulose, hydroxyethylstarch, hydroxypropylguar, etc. can be degraded with hydrogen peroxide to lower the molecular weight to the desired level. A preferred polysaccharide is hydrophobically modified hydroxyethylcellulose with a weight percent hydrophobe substitution of 0.2 to 2.0. A preferred synthetic polymer is hydrophobically modified poly(vinyl alcohol) with a molecular weight of 10,000 to 50,000.

  分子量在 10,000 至 300,000 之间的疏水改性多糖和合成聚合物可用作水性保护涂料中的缔合增稠剂，在不影响流挂或增稠效率的情况下实现（-NORTH-）漂白。疏水改性的羟乙基纤维素、羟乙基淀粉、羟丙基瓜尔胶等可以用过氧化氢降解，将分子量降到所需的水平。一种优选的多糖是疏水改性的羟乙基纤维素，其疏水取代物的重量百分比为 0.2 至 2.0。一种优选的合成聚合物是分子量为 10,000 至 50,000 的疏水改性聚乙烯醇。
• COSMETIC
  申请人：Shiseido Company, Limited

  公开号：EP2103300A1

  公开（公告）日：2009-09-23

  The present invention provides a cosmetic having equal to or a higher antioxidantactivity and moisture retaining property than the above-described conventional vitamin E derivatives. The cosmetic also has an excellent emulsifying ability and solubilizing ability and remarkably reduces a sticky feeling on the skin (in particular, the sticky feeling during drying after the application on the skin). That is, the cosmetic of the present invention containinga vitamin E derivative represented by the following formula (I) or a salt thereof. [ In the formula, R1, R2 , and R3 represent a hydrogen atom or a methyl group; R4 represents a C1-6 alkanoyl group, a C1-6 alkyl group, a SO3H group, a P(O)(OH)2 group, a CH2COOH group or a COCH2CH(SO3H)COOH group; EO represents an ethylene oxide group; BO represents a butylene oxide group; k and n independently represent any one of numbers 0 to 30; and m represents any one of numbers 1 to 30.]

  本发明提供了一种化妆品，其抗氧化活性和保湿性能等同于或高于上述传统维生素 E 衍生物。本发明的化妆品还具有出色的乳化能力和增溶能力，并能显著减少皮肤上的粘腻感（尤其是涂抹在皮肤上后干燥时的粘腻感）。 也就是说，本发明的化妆品含有下式（I）代表的维生素 E 衍生物或其盐。 [式中，R1、R2 和 R3 代表氢原子或甲基；R4 代表 C1-6 烷酰基、C1-6 烷基、SO3H 基、P(O)(OH)2 基、CH2COOH 基或 COCH2CH(SO3H)COOH 基；EO 代表环氧乙烷基；BO 代表环氧丁烯基；k 和 n 独立地代表数字 0 至 30 中的任意一个；m 代表数字 1 至 30 中的任意一个。］