2-((4-methoxyphenyl)thio)-1-(p-tolyl)ethanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-((4-methoxyphenyl)thio)-1-(p-tolyl)ethanol
• 英文别名: 2-(4-Methoxyphenyl)sulfanyl-1-(4-methylphenyl)ethanol
• 化学式: C₁₆H₁₈O₂S
• 分子量: 274.384
• InChiKey: JIEAJLMGLJONNP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  54.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  Alpha-甲基苯乙烯 、 4-甲氧基苯硫酚 在 氧气 、 β-环糊精 作用下， 以 水 、 丙酮 为溶剂， 反应 4.0h， 以82%的产率得到2-((4-methoxyphenyl)thio)-1-(p-tolyl)ethanol
  参考文献：
  名称：

  Synthesis of β-Hydroxysulfides from Alkenes under Supramolecular Catalysis in the Presence of β-Cyclodextrin in Water

  摘要：

  An environmentally benign and highly efficient procedure has been developed for the direct one-pot synthesis of beta-hydroxysulfides in good yields under neutral conditions from alkenes and thiophenols in the presence of aerial oxygen using beta-cyclodextrin in water. This protocol tolerates a wide variety of functional groups or substrates and does not require the use of either acid or base catalysts. beta-Cyclodextrin can be recovered and reused for a number of runs without any loss of activity.

  DOI：

  10.1021/jo060805a

文献信息

• One-pot synthesis of β-hydroxysulfides from styrenes and disulfides using the Zn/AlCl3 system
  作者：Barahman Movassagh、Mozhgan Navidi

  DOI：10.1016/j.tetlet.2008.09.071

  日期：2008.11

  A simple, general, and highly regioselective procedure has been developed for the one-pot synthesis of β-hydroxysulfides in good yields from various styrenes and disulfides by cleavage of the S–S bond with a Zn/AlCl3 system in aqueous acetonitrile at 80 °C and in the presence of oxygen.

  已开发出一种简单，通用且具有高度区域选择性的方法，用于通过一锅法从80℃的乙腈水溶液中用Zn / AlCl 3系统裂解S–S键，以多种苯乙烯和二硫化物的高收率一站式合成β-羟基硫化物。°C并在有氧气的情况下。
• Synthesis of β-Hydroxysulfides from Alkenes under Supramolecular Catalysis in the Presence of β-Cyclodextrin in Water
  作者：K. Surendra、N. Srilakshmi Krishnaveni、R. Sridhar、K. Rama Rao

  DOI：10.1021/jo060805a

  日期：2006.7.1

  An environmentally benign and highly efficient procedure has been developed for the direct one-pot synthesis of beta-hydroxysulfides in good yields under neutral conditions from alkenes and thiophenols in the presence of aerial oxygen using beta-cyclodextrin in water. This protocol tolerates a wide variety of functional groups or substrates and does not require the use of either acid or base catalysts. beta-Cyclodextrin can be recovered and reused for a number of runs without any loss of activity.
• Light-Promoted and Tertiary-Amine-Assisted Hydroxysulfenylation of Alkenes: Selective and Direct One-Pot Synthesis of β-Hydroxysulfides
  作者：Jing Shi、Xue-Wang Gao、Qing-Xiao Tong、Jian-Ji Zhong

  DOI：10.1021/acs.joc.1c01610

  日期：2021.9.17