N-Boc-2-(4-chlorophenylthio)cyclohexylamine

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: N-Boc-2-(4-chlorophenylthio)cyclohexylamine
• 英文别名: tert-butyl N-[2-(4-chlorophenyl)sulfanylcyclohexyl]carbamate
• 化学式: C₁₇H₂₄ClNO₂S
• 分子量: 341.902
• InChiKey: DSVAYTZRFNXZEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氯苯硫酚 、 N-tert-butoxycarbonyl-7-azabicyclo<4.1.0>hexane 在 dipotassium hydrogenphosphate 、 (S)-benzyl(2-(3,5-bis(trifluoromethyl)benzamido)-3,3-dimethylbutyl)diphenylphosphonium bromide 作用下， 以 四氯化碳 为溶剂， 反应 9.0h， 以99%的产率得到N-Boc-2-(4-chlorophenylthio)cyclohexylamine
  参考文献：
  名称：

  Enantioselective desymmetrization of meso-aziridines with aromatic thiols catalyzed by chiral bifunctional quaternary phosphonium salts derived from α-amino acids

  摘要：

  Desymmetrization of meso-aziridines with aromatic thiols was realized by using alpha-amino acids-derived chiral quaternary phosphonium salts catalysts to provide chiral beta-amino sulfides with high yields (up to 99%) and in moderate enantioselectivities (up to 70%). (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.02.001

文献信息

• An efficient procedure for cleavage of aziridines with various thiols promoted by ZnCl2
  作者：Jie Wu、Xue-Long Hou、Li-Xin Dai

  DOI：10.1039/b100591j

  日期：——

  The ring-opening reaction of aziridines with various thiophenols and thiols catalyzed by ZnCl2 provides β-amino sulfides in high yield.

  由ZnCl2催化的氮杂环烯与各种噻吩酚和硫醇的开环反应能高产量地生成β-氨基硫化物。
• Enantioselective desymmetrization of meso-aziridines with aromatic thiols catalyzed by chiral bifunctional quaternary phosphonium salts derived from α-amino acids
  作者：Jiaxing Zhang、Dongdong Cao、Hongyu Wang、Gang Zhao、Yongjia Shang

  DOI：10.1016/j.tet.2015.02.001

  日期：2015.3

  Desymmetrization of meso-aziridines with aromatic thiols was realized by using alpha-amino acids-derived chiral quaternary phosphonium salts catalysts to provide chiral beta-amino sulfides with high yields (up to 99%) and in moderate enantioselectivities (up to 70%). (C) 2015 Elsevier Ltd. All rights reserved.