N-n-propyl-2-fluoroacetamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-n-propyl-2-fluoroacetamide
• 英文别名: 2-fluoro-N-propylacetamide
• 化学式: C₅H₁₀FNO
• 分子量: 119.139
• InChiKey: MYRBCSSKESLOSN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  正丙胺 、 氟代乙酰氯 在 氢氧化钾 作用下， 以 乙醚 为溶剂， 反应 5.0h， 以63%的产率得到N-n-propyl-2-fluoroacetamide
  参考文献：
  名称：

  Synthesis of some new N-monosubstituted fluoroacetamides

  摘要：

  Twenty new N-monosubstituted fluoroacetamides with potential toxicological proper-ties have been synthesized by acylation of the corresponding amines with fluoroacetyl chloride. The substituents were cycloalkyl or various alkyl (with straight or branched carbon chain) groups. The yields ranged from 50 to 92%.

  DOI：

  10.1016/s0022-1139(00)82416-1

文献信息

• Synthesis of some new N-monosubstituted fluoroacetamides
  作者：S. Mis̆c̆ević、D. Minić、S. Petrović

  DOI：10.1016/s0022-1139(00)82416-1

  日期：1992.11

  Twenty new N-monosubstituted fluoroacetamides with potential toxicological proper-ties have been synthesized by acylation of the corresponding amines with fluoroacetyl chloride. The substituents were cycloalkyl or various alkyl (with straight or branched carbon chain) groups. The yields ranged from 50 to 92%.