化合物JPH203DIHYDROCHLORIDE | 1597402-27-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 化合物JPH203DIHYDROCHLORIDE
• 中文别名: O-[(5-氨基-2-苯基-7-苯并恶唑基)甲基]-3,5-二氯-L-酪氨酸二盐酸盐
• 英文名称: JPH203 Dihydrochloride
• 英文别名: (2S)-2-amino-3-[4-[(5-amino-2-phenyl-1,3-benzoxazol-7-yl)methoxy]-3,5-dichlorophenyl]propanoic acid;dihydrochloride
• CAS: 1597402-27-1
• 化学式: C23H21Cl4N3O4
• 分子量: 545.2
• InChiKey: MJSAOPNUSNNYQL-NTEVMMBTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.76
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  125
• 氢给体数：
  5
• 氢受体数：
  7

文献信息

• Anticancer agent composition
  申请人：J-Pharma Co., Ltd.

  公开号：US10172835B2

  公开（公告）日：2019-01-08

  A method for treating cancer includes administering to a subject in need of the treatment an anticancer agent composition that includes the following agents as active ingredients; a LAT1 inhibitor, and one or more agents selected from the group consisting of an alkylating agent, a platinum-based antineoplastic agent, an anti-metabolite, a topoisomerase inhibitor, an anti-microtubule polymerizing agent, a hormonal agent, an anti-microtubule depolymerizing agent, an anticancer antibiotic, and a molecular targeted agent.

  一种治疗癌症的方法包括向需要治疗的受试者施用抗癌剂组合物，该组合物包括作为活性成分的下列制剂；LAT1抑制剂，以及选自以下组别的一种或多种制剂：烷化剂、铂类抗肿瘤剂、抗代谢剂、拓扑异构酶抑制剂、抗微管聚合剂、激素制剂、抗微管解聚剂、抗癌抗生素和分子靶向制剂。
• AN ANTICANCER AGENT COMPOSITION
  申请人：J-PHARMA CO., LTD.

  公开号：US20160279103A1

  公开（公告）日：2016-09-29

  A method for treating cancer includes administering to a subject in need of the treatment an anticancer agent composition that includes the following agents as active ingredients; a LAT1 inhibitor, and one or more agents selected from the group consisting of an alkylating agent, a platinum-based antineoplastic agent, an anti-metabolite, a topoisomerase inhibitor, an anti-microtubule polymerizing agent, a hormonal agent, an anti-microtubule depolymerizing agent, an anticancer antibiotic, and a molecular targeted agent.