methyl 2-amidino-2-ethoxyiminoacetate hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 2-amidino-2-ethoxyiminoacetate hydrochloride
• 英文别名: methyl (2E)-3-amino-2-ethoxyimino-3-iminopropanoate;hydrochloride
• 化学式: C₆H₁₁N₃O₃*ClH
• 分子量: 209.633
• InChiKey: ZOCLQAMUGAPCSF-JOKMOOFLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.09
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  97.8
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  methyl 3-imino-3-ethoxy-2-ethoxyiminopropionate 在 ammonium chloride 作用下， 以 甲醇 为溶剂， 生成 methyl 2-amidino-2-ethoxyiminoacetate hydrochloride
  参考文献：
  名称：

  Cephem compounds

  摘要：

  这项发明涉及具有抗微生物活性的新化合物的公式##STR1##其中R.sup.1是氨基或保护的氨基团，R.sup.2是环(较低)烷基、环(较低)烯基、较低烷基、较低炔基、羧基(较低)烷基、保护的羧基(较低)烷基或较低烷基硫(较低)烷基，Y是氢、氨基或保护的氨基团，以及其药用可接受的盐。

  公开号：

  US04407798A1

文献信息

• New cephem compounds and processes for preparation thereof
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0046964A2

  公开（公告）日：1982-03-10

  A compound of the formula: in which R1 is amino or a protected amino group, R2 is an aliphatic hydrocarbon residue which may have suitable substituent(s), X is N or CH, and Y is hydrogen, amino or a protected amino group; and pharmaceutically acceptable salts thereof, and processes for their preparation and also a pharmaceutically composition comprising, as an effective ingredient, the above compound in association with pharmaceutically acceptable carriers.

  式的化合物： 其中 R1 是氨基或受保护的氨基、 R2 是脂肪烃残基，可具有合适的取代基、 X 是 N 或 CH，以及 Y 是氢、氨基或受保护的氨基； 及其药学上可接受的盐，以及其制备工艺和一种药用组合物，该组合物作为有效成分包含上述化合物与药学上可接受的载体。
• New cephem compounds, processes for their preparation, pharmaceutical compositions containing them and intermediate products for their preparation
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0074653A2

  公开（公告）日：1983-03-23

  New cephem cumpounds of the formula: wherein R' is ammo or a protected amino group. R2 is lower aliphatic hydrocarbon group which may be substituted with suitable substituent(s), cylclopower)lalkyl or cyclo(lower)alkenyl; R3 defines certain subsituents, R4 is hydrogen or lower alkyl, and pharmaceutically acceptable salts thereof, processes for their preparation, and a pharmaceutrcal antibacterial composition comprising the above compound in associationwith a pharmaceutically acceptable substantially carrier or excipient.The Invention refers also to compounds of the formula

  式中的新头孢化合物： 式中 R' 是氨基或受保护的氨基。 R2 是可被适当取代基取代的低级脂肪烃基、环烷基或环（低级）烯基； R3 定义某些亚基、 R4 是氢或低级烷基，及其药学上可接受的盐、制备工艺，以及由上述化合物与药学上可接受的基本载体或赋形剂组成的药用抗菌组合物。
• New starting compounds for the preparation of cephem compounds and processes for preparation thereof
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0156118A1

  公开（公告）日：1985-10-02

  A compound of the formula: wherein R1 is amino or a protected amino group, X is N or CH, and R5 is ethyl, cyclo (lower) alkyl, cyclo (lower) alkenyl, lower alkyl having a protected carboxy group, lower alkynyl or lower alkylthio(lower)alkyl, provided that X is N when R5 is lower alkynyl and R' is amino when R5 is ethyl, or a salt therof, and processes fortheir preparation. The compounds are useful as starting material for the preparation of pharmaceutically active cephem compounds.

  式中 R1 为氨基或受保护的氨基，X 为 N 或 CH，R5 为乙基、环（低级）烷基、环（低级）烯基、具有受保护的羧基的低级烷基、低级炔基或低级烷硫基（低级）烷基（当 R5 为低级炔基时，X 为 N；当 R5 为乙基时，R'为氨基）的化合物或其盐及其制备方法。 这些化合物可用作制备具有药用活性的头孢化合物的起始原料。
• Process for preparing intermediate products and their use for preparing cephem compounds
  申请人：FUJISAWA PHARMACEUTICAL CO., LTD.

  公开号：EP0231475A1

  公开（公告）日：1987-08-12

  A process for preparing a compound of the formula : wherein R2 is lower aliphatic hydrocarbon group which may be substituted with suitable substituent(s), cyclo(lower)alkyl or cyclo(lower)alkenyl; or a salt thereof, which comprises reacting a compound of the formula : wherein R2 is as defined above and Y is halogen, or a salt thereof, with a salt of HSCN. The obtained compounds are intermediates which can be used for preparing cephem compounds.

  一种制备式中 R2 为可被适当取代基取代的低级脂族烃基、环（低）烷基或环（低）烯基；或其盐的化合物的工艺，包括将式中 R2 如上定义且 Y 为卤素的化合物或其盐与 HSCN 的盐反应。 得到的化合物为中间体，可用于制备 cephem 化合物。
• US4407798A
  申请人：——

  公开号：US4407798A

  公开（公告）日：1983-10-04