N-(1-biphenyl-4-yl-ethylidene)-N'-(2,4,6-trichlorophenyl)-hydrazine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1-biphenyl-4-yl-ethylidene)-N'-(2,4,6-trichlorophenyl)-hydrazine
• 英文别名: 2,4,6-trichloro-N-[1-(4-phenylphenyl)ethylideneamino]aniline
• 化学式: C₂₀H₁₅Cl₃N₂
• 分子量: 389.711
• InChiKey: VFSJPURAUFNNFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.3
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N-(1-biphenyl-4-yl-ethylidene)-N'-(2,4,6-trichlorophenyl)-hydrazine 在 次氯酸叔丁酯 作用下， 以 氯仿 为溶剂， 反应 3.0h， 以94%的产率得到(1-biphenyl-4-yl-1-chloro-ethyl)-(2,4,6-trichlorobenzene)
  参考文献：
  名称：

  Synthesis of 1,2,4-triazolium salts: Reaction of 1-azo-2-azonia-allene salts with nitriles

  摘要：

  Alkyl ketone hydrazones 1 are oxidized with tert-butylhypochlorite to give geminal chloro azo compounds 2. These react with SbCl5, to give 1-aza-2-azonia-allene salts 3 as reactive intermediates which are intercepted with nitriles to yield 3H-1,2,4-triazolium salts 5. In most cases these salts rearrange spontaneously to form 1H-triazolium salts 6. Hydrolysis of 6e-g by NaOH provide bases 7a-c, which react with picric acid to give 1H-pyrazolium picrates 8.

  DOI：

  10.1007/bf00813205
• 作为产物：
  描述：

  联苯单乙酮 、 2,4,6-三氯苯肼 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 5.0h， 以92%的产率得到N-(1-biphenyl-4-yl-ethylidene)-N'-(2,4,6-trichlorophenyl)-hydrazine
  参考文献：
  名称：

  Synthesis of 1,2,4-triazolium salts: Reaction of 1-azo-2-azonia-allene salts with nitriles

  摘要：

  Alkyl ketone hydrazones 1 are oxidized with tert-butylhypochlorite to give geminal chloro azo compounds 2. These react with SbCl5, to give 1-aza-2-azonia-allene salts 3 as reactive intermediates which are intercepted with nitriles to yield 3H-1,2,4-triazolium salts 5. In most cases these salts rearrange spontaneously to form 1H-triazolium salts 6. Hydrolysis of 6e-g by NaOH provide bases 7a-c, which react with picric acid to give 1H-pyrazolium picrates 8.

  DOI：

  10.1007/bf00813205

文献信息

• Synthesis of 1,2,4-triazolium salts: Reaction of 1-azo-2-azonia-allene salts with nitriles
  作者：A. M. Amer

  DOI：10.1007/bf00813205

  日期：1995.4

  Alkyl ketone hydrazones 1 are oxidized with tert-butylhypochlorite to give geminal chloro azo compounds 2. These react with SbCl5, to give 1-aza-2-azonia-allene salts 3 as reactive intermediates which are intercepted with nitriles to yield 3H-1,2,4-triazolium salts 5. In most cases these salts rearrange spontaneously to form 1H-triazolium salts 6. Hydrolysis of 6e-g by NaOH provide bases 7a-c, which react with picric acid to give 1H-pyrazolium picrates 8.