2-Cyanoaziridine-1-(N-butyl) carboxamide

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-Cyanoaziridine-1-(N-butyl) carboxamide
• 英文别名: 2-Cyanoaziridine-1-(N-butyl)carboxamide；Aziridine-2-carbonitrile;pentanamide
• 化学式: C₃H₄N₂*C₅H₁₁NO
• 分子量: 169.227
• InChiKey: MDEZFBWCVVCGEI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.14
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  88.8
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氮丙啶甲腈 、 异氰酸正丁酯 以92%的产率得到2-Cyanoaziridine-1-(N-butyl) carboxamide
  参考文献：
  名称：

  Cyanoaziridines for treating cancer

  摘要：

  本发明涉及一种新型的抗癌化合物，其化学式为：其中X为CN，R4为氢或低碳基；R5为低碳基，低环烷基，烯基，炔基，芳基，单取代芳基，双取代芳基，芳基低碳基，低氧代羰基低碳基，或杂环，但当X为CN，R4为氢时，R5不为CH3，C6H5或对硝基苯基。R4，R5和N共同形成一个杂环。

  公开号：

  US06297230B1

文献信息

• Liposomal imexon
  申请人：——

  公开号：US20030129222A1

  公开（公告）日：2003-07-10

  Disclosed are novel compositions comprising a lipid and imexon or a derivative thereof. Also disclosed are liposomal compositions comprising imexon or a derivative thereof. Methods for administrating pharmaceutically acceptable compositions comprising a lipid and imexon or a derivative thereof for the treatment of diseases, such as cancer, are also disclosed herein.

  披露了包含脂质和伊美酮或其衍生物的新型组合物。还披露了包含伊美酮或其衍生物的脂质体组合物。本文还披露了用于治疗疾病（如癌症）的含有脂质和伊美酮或其衍生物的药用合成物的管理方法。
• [EN] COMPOSITION COMPRISING AN IMEXON OR DERIVATIVES THEREOF AND LIPIDS<br/>[FR] IMEXON LIPOSOMIQUE
  申请人：——

  公开号：WO2002041871A9

  公开（公告）日：2003-05-30

  [EN] Disclosed are novel compositions comprising a lipid and imexon or a derivative thereof. Also disclosed are liposomal compositions comprising imexon or derivative thereof. Methods for administrating pharmaceutically acceptable compositions comprising a lipid and imexon or a derivative thereof for the treatment of diseases, such as cancer, are also disclosed herein.
  [FR] L'invention concerne de nouvelles compositions comprenant un lipide et de l'iméxon ou un dérivé de ce dernier. L'invention traite aussi de compositions liposomiques comprenant de l'iméxon ou un dérivé de ce dernier. L'invention a aussi pour objet des procédés permettant d'administrer des compositions pharmaceutiquement acceptables comprenant un lipide et de l'iméxon ou un dérivé de ce dernier pour traiter les maladies, telles que le cancer.
• [EN] LIPOSOMAL IMEXON<br/>[FR] IMEXON LIPOSOMIQUE
  申请人：UNIV TEXAS

  公开号：WO2002041871A2

  公开（公告）日：2002-05-30

  Disclosed are novel compositions comprising a lipid and imexon or a derivative thereof. Also disclosed are liposomal compositions comprising imexon or derivative thereof. Methods for administrating pharmaceutically acceptable compositions comprising a lipid and imexon or a derivative thereof for the treatment of diseases, such as cancer, are also disclosed herein.