2-[1'-(N-p-methoxyphenylamino)-1'-phenyl]methylcycloheptanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-[1'-(N-p-methoxyphenylamino)-1'-phenyl]methylcycloheptanone
• 英文别名: 2-[(4-Methoxyanilino)-phenylmethyl]cycloheptan-1-one；2-[(4-methoxyanilino)-phenylmethyl]cycloheptan-1-one
• 化学式: C₂₁H₂₅NO₂
• 分子量: 323.435
• InChiKey: VSPIVWAUBRIQTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯甲醛 、 甲氧苯胺 、 环庚酮 在 十二烷基苯磺酸 作用下， 以 水 为溶剂， 反应 12.0h， 以89%的产率得到2-[1'-(N-p-methoxyphenylamino)-1'-phenyl]methylcycloheptanone
  参考文献：
  名称：

  Mannich-Type Reactions of Aldehydes, Amines, and Ketones in a Colloidal Dispersion System Created by a Brønsted Acid−Surfactant-Combined Catalyst in Water

  摘要：

  [GRAPHICS]Three-component Mannich-type reactions of aldehydes, amines, and ketones were efficiently catalyzed by dodecylbenzenesulfonic acid at ambient temperature in water to give various beta-amino ketones in good yields. The same reactions proceeded sluggishly in organic solvents.

  DOI：

  10.1021/ol991113u

文献信息

• Mannich-Type Reactions of Aldehydes, Amines, and Ketones in a Colloidal Dispersion System Created by a Brønsted Acid−Surfactant-Combined Catalyst in Water
  作者：Kei Manabe、Shū Kobayashi

  DOI：10.1021/ol991113u

  日期：1999.12.1

  [GRAPHICS]Three-component Mannich-type reactions of aldehydes, amines, and ketones were efficiently catalyzed by dodecylbenzenesulfonic acid at ambient temperature in water to give various beta-amino ketones in good yields. The same reactions proceeded sluggishly in organic solvents.
• Three-component carbon–carbon bond-forming reactions catalyzed by a Brønsted acid–surfactant-combined catalyst in water
  作者：Kei Manabe、Yuichiro Mori、Shū Kobayashi

  DOI：10.1016/s0040-4020(01)00081-3

  日期：2001.3

  Reactions of aldehydes, amines, and various nucleophiles such as silyl enolates, ketones, Danishefsky's diene, and allyltribuyltin in water were successfully carried out in the presence of p-dodecylbenzenesulfonic acid (DBSA) as a Bronsted acid-surfactant-combined catalyst. (C) 2001 Elsevier Science Ltd. All rights reserved.