methyl cytisinylacetate

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 羽扇豆生物碱
• 英文名称: methyl cytisinylacetate
• 英文别名: methyl 2-[(1S,9R)-6-oxo-7,11-diazatricyclo[7.3.1.02,7]trideca-2,4-dien-11-yl]acetate
• 化学式: C₁₄H₁₈N₂O₃
• 分子量: 262.309
• InChiKey: ZKPHYUDUHAIMCK-MNOVXSKESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  49.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  重氮乙酸甲酯 、 cytisine 在 tetraacetatodiruthenium chloride 作用下， 以 苯 为溶剂， 反应 20.5h， 以20%的产率得到methyl cytisinylacetate
  参考文献：
  名称：

  Reaction of Methyl Diazoacetate with Amines Catalyzed by Ru2(OAc)4Cl

  摘要：

  Reactions of primary and secondary amines with methyl diazoacetate in the presence of Ru-2(OAc)(4)Cl gave the corresponding N-substituted glycine methyl esters in almost quantitative yield. Catalytic decomposition of methyl diazoacetate generates methoxycarbonylcarbene which is inserted into the N-H bond of amines with high regioselectivity.

  DOI：

  10.1134/s1070428010100039

文献信息

• Reaction of Methyl Diazoacetate with Amines Catalyzed by Ru2(OAc)4Cl
  作者：A. V. Maidanova、A. D. Bakeeva、R. M. Sultanova、R. Z. Biglova、V. A. Dokichev

  DOI：10.1134/s1070428010100039

  日期：2010.10

  Reactions of primary and secondary amines with methyl diazoacetate in the presence of Ru-2(OAc)(4)Cl gave the corresponding N-substituted glycine methyl esters in almost quantitative yield. Catalytic decomposition of methyl diazoacetate generates methoxycarbonylcarbene which is inserted into the N-H bond of amines with high regioselectivity.