槐果碱

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 羽扇豆生物碱
• 中文名称: 槐果碱
• 中文别名: 槐果碱氢溴酸盐
• 英文名称: (1R,2R,9S,17S)-7,13-diazatetracyclo[7.7.1.02,7.013,17]heptadec-4-en-6-one;hydron;bromide
• 化学式: C15H23BrN2O
• 分子量: 327.26
• InChiKey: NBBQEIQEBNYSFK-PUILLJIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.23
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  23.6
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Compounds, extracts and methods from chinese medicinal herb sophora flavescens that inhibit airway contraction
  申请人：Li Xiu-Min

  公开号：US10406191B2

  公开（公告）日：2019-09-10

  The present invention relates to extracts of Sophora Flavescens, and compounds isolated therefrom for use in modulating airway smooth muscle contractility. Methods of creating enriched extracts of Sophora Flavescens are disclosed, as are specific compounds isolated therefrom. Methods for the treatment of disorders involving airway smooth muscle, such as asthma, using the compounds and extracts described herein are also disclosed.

  本发明涉及槐花提取物以及从中分离出的用于调节气道平滑肌收缩力的化合物。本发明公开了富集槐花提取物的方法，以及从中分离出的特定化合物。还公开了使用本文所述化合物和提取物治疗气道平滑肌疾病（如哮喘）的方法。
• COMPOUNDS, EXTRACTS AND METHODS FROM CHINESE MEDICINAL HERB SOPHORA FLAVESCENS THAT INHIBIT AIRWAY CONTRACTION
  申请人：LI Xiu-Min

  公开号：US20150359834A1

  公开（公告）日：2015-12-17

  The present invention relates to extracts of Sophora Flavascens , and compounds isolated therefrom for use in modulating airway smooth muscle contractility. Methods of creating enriched extracts of Sophora Flavascens are disclosed, as are specific compounds isolated therefrom. Methods for the treatment of disorders involving airway smooth muscle, such as asthma, using the compounds and extracts described herein are also disclosed.