2,3-dihydro-7-methyl-1,4-oxathiin

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2,3-dihydro-7-methyl-1,4-oxathiin
• 英文别名: 7-Methyl-2,3-dihydro-1,4-benzoxathiine
• 化学式: C₉H₁₀OS
• 分子量: 166.244
• InChiKey: LVEWRSMKMWBOPL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  34.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-巯基乙醇 、 3-甲基环己酮 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以81%的产率得到2,3-dihydro-7-methyl-1,4-oxathiin
  参考文献：
  名称：

  A Facile One-Pot Preparation of 2,3-Dihydro-1,4-benzodithiins and 2,3-Dihydro-1,4-benzoxathiins

  摘要：

  2,3-Dihydro-1,4-benzodithiines and 2,3-dihydro-1,4-benzoxathiines were prepared in good yields by a one-pot procedure from the reaction of cyclohexanone derivatives with ethane-1,2-dithiol or 2-mercaptoethanol using N-bromosuccinimide in dichloromethane at 0-degrees-C.

  DOI：

  10.3987/com-93-6348

文献信息

• A new route to 2,3-dihydro-1,4-benzoxathiine and 2,3-dihydro-1,4-benzodithiine
  作者：James Y. Satoh、Amos M. Haruta、Christopher T. Yokoyama、Yasuo Yamada、Masakatsu Hirose

  DOI：10.1039/c39850001645

  日期：——

  The ethylene monothioacetals and dithioacetals of alkylcyclohexanones react with copper(II) bromide to give 2,3-dihydro-1,4-benzoxathiine and 2,3-dihydro-1,4-benzodithiine derivatives, respectively.

  烷基环己酮的乙烯单硫缩醛和二硫缩醛与溴化铜（II）反应，分别得到2,3-二氢-1,4-苯并benzo啶和2,3-二氢-1,4-苯并二硫胺衍生物。
• Oxo-tetrahydro-isoquinoline carboxylic acids as STING inhibitors
  申请人：Merck Sharp & Dohme Corp.

  公开号：US11311528B2

  公开（公告）日：2022-04-26

  The instant invention provides compounds of formula I which are STING inhibitors, and as such are useful for the treatment of STING-mediated diseases such as inflammation, asthma, COPD and cancer.

  本发明提供的式 I 化合物是 STING 抑制剂，因此可用于治疗 STING 介导的疾病，如炎症、哮喘、慢性阻塞性肺病和癌症。
• OXO-TETRAHYDRO-ISOQUINOLINE CARBOXYLIC ACIDS AS STING INHIBITORS
  申请人：NEEDHAM Michael D.

  公开号：US20210052573A1

  公开（公告）日：2021-02-25

  The instant invention provides compounds of formula I which are STING inhibitors, and as such are useful for the treatment of STING-mediated diseases such as inflammation, asthma, COPD and cancer.
• US9795550B2
  申请人：——

  公开号：US9795550B2

  公开（公告）日：2017-10-24
• A Facile One-Pot Preparation of 2,3-Dihydro-1,4-benzodithiins and 2,3-Dihydro-1,4-benzoxathiins
  作者：Hiroyuki Tani、Shunsuke Irie、Kazunori Masumoto、Noboru Ono

  DOI：10.3987/com-93-6348

  日期：——

  2,3-Dihydro-1,4-benzodithiines and 2,3-dihydro-1,4-benzoxathiines were prepared in good yields by a one-pot procedure from the reaction of cyclohexanone derivatives with ethane-1,2-dithiol or 2-mercaptoethanol using N-bromosuccinimide in dichloromethane at 0-degrees-C.