para-chlorothiophenol

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: para-chlorothiophenol
• 英文别名: 4-chlorothiophenol；4-Chloro-thiophenol；4-ClC6H4SH；4-chlorothio phenol；(4-Hydroxyphenyl) thiohypochlorite
• 化学式: C₆H₅ClOS
• 分子量: 160.624
• InChiKey: QONAEIZLFQVDLS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  para-chlorothiophenol 在 盐酸 、 sodium tetrahydroborate 、 m-chloroperoxybenzoic acid 、 potassium tert-butylate 、 水 、 溶剂黄146 、 三乙胺 、 sodium chloride 、 氯甲酸异丁酯 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 、 二甲基亚砜 、 甲苯 为溶剂， 反应 44.0h， 生成 [4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexyl]-methanol
  参考文献：
  名称：

  WO2006/123182

  摘要：

  公开号：

文献信息

• [EN] NOVEL VIRAL REPLICATION INHIBITORS<br/>[FR] NOUVEAUX INHIBITEURS DE RÉPLICATION VIRALE
  申请人：UNIV LEUVEN KATH

  公开号：WO2011015641A1

  公开（公告）日：2011-02-10

  The present invention relates to a series of novel compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to methods for the preparation of such compounds, as well as to novel intermediates useful in one or more steps of such syntheses. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. This invention further relates to the use of such compounds as medicines or in the manufacture of a medicament useful for the treatment of animals suffering from viral infections, in particular HIV infection. This invention further relates to methods for the treatment of viral infections in animals by the administration of a therapeutical amount of such compounds, optionally combined with one or more other drugs having antiviral activity.

  本发明涉及一系列具有抗病毒活性的新化合物，更具体地说是具有抑制HIV（人类免疫缺陷病毒）复制的特性。该发明还涉及制备这些化合物的方法，以及在这些合成步骤中使用的新中间体。该发明还涉及包含这些化合物作为活性成分的有效量的药物组合物。本发明进一步涉及将这些化合物用作药物或用于制造对患有病毒感染，特别是HIV感染的动物进行治疗的药物。本发明还涉及通过给动物投予这些化合物的治疗量，可选择地与具有抗病毒活性的一个或多个其他药物结合的方法来治疗动物的病毒感染。
• Sulfonamide derivatives and drugs containing the same as the active ingredient
  申请人：Hidaka Hiroyoshi

  公开号：US06403607B1

  公开（公告）日：2002-06-11

  The present invention discloses a sulfonamide derivative represented by the following formula (1): [wherein A represents a nitrogen atom, —CH═, etc.; Z represents an oxygen atom, etc.; Ar1 represents an aryl group, etc.; Ar2 represents an alkyl group, etc.; Ra represents a hydrogen atom, etc.; Rb represents a hydrogen atom, etc.; and Rc represents an alkyl group, etc.], or a salt thereof; and drugs containing the derivative or a salt thereof as an active ingredient. This compound exhibits radical scavenging action, gastric mucous secretion augmenting action, and anti-HP action, and thus is effective as a peptic ulcer therapeutic agent.

  本发明公开了一种由以下式（1）表示的磺胺衍生物：[其中A代表氮原子，-CH，等；Z代表氧原子，等；Ar1代表芳基，等；Ar2代表烷基，等；Ra代表氢原子，等；Rb代表氢原子，等；Rc代表烷基，等]，或其盐；以及含有该衍生物或其盐作为活性成分的药物。该化合物表现出自由基清除作用、增加胃粘液分泌作用和抗幽门螺杆菌作用，因此作为溃疡治疗药物具有有效性。
• Novel amides that activate soluble guanylate cyclase
  申请人：——

  公开号：US20040192680A1

  公开（公告）日：2004-09-30

  Compounds of formula (I) 1 are useful for increasing cGMP levels in a mammal.

  化合物的化学式(I)1对于增加哺乳动物体内的cGMP水平是有用的。
• Method for producing an olefin type copolymer having a cyclic structure
  申请人：MARUZEN PETROCHEMICAL CO., LTD.

  公开号：US20020058767A1

  公开（公告）日：2002-05-16

  A method for producing an olefin type copolymer having a cyclic structure, which comprises copolymerizing ethylene (M1) and dicyclopentadiene or tricyclopentadiene (M2), and, as optionally introduced, a cyclic olefin (M3), wherein, as a catalyst, a catalyst comprising a metallocene compound (A) of the following formula [1]: H 2 C(R′ m CP)(R″ n Cp)Mx 2 [1] wherein M is zirconium or hafnium, Cp is a group having a cyclopentadienyl skeleton, each of R′ and R″ is a hydrocarbon group having 1 to 10 carbon atoms, each of two X's which may be the same or different from each other, is a halogen atom, a hydrogen atom, a hydrocarbon group having 1 to 20 carbon atoms, a halogenated hydrocarbon group, an alkylamino group, an alkoxy group, an aryloxy group of the formula —O—Ar—Y p (wherein Ar is an aromatic ring, Y is a halogen atom, a hydrogen atom, a hydrocarbon group having 1 to 20 carbon atoms, a halogenated hydrocarbon group, an alkoxy group, an alkylamino group, a cyano group or a nitro group, and p is an integer of from 1 to 5), a thioalkyl group, or a thioaryl group of the formula —S—Ar—Y p (wherein Ar, Y and p are as defined above), and each of m and n is an integer of from 0 to 4, provided that m and n are not equal, and m+n is an integer of from 3 to 6, and an aluminoxane (B), is used.

  一种制备具有环状结构的烯烃共聚物的方法，包括共聚乙烯（M1）和二环戊二烯或三环戊二烯（M2），以及作为可选引入的环状烯烃（M3），其中，作为催化剂使用以下式子（1）的金属茂化合物（A）：H2C(R′mCP)(R″nCp)Mx2（1），其中M为锆或铪，Cp为具有环戊二烯基骨架的基团，R′和R″各自为具有1至10个碳原子的碳氢基团，两个X可以相同也可以不同，是卤素原子、氢原子、具有1至20个碳原子的碳氢基团、卤代碳氢基团、烷基氨基基团、烷氧基、苯氧基（式中Ar为芳香环，Y为卤素原子、氢原子、具有1至20个碳原子的碳氢基团、卤代碳氢基团、烷氧基、烷基氨基基团、氰基或硝基，p为1至5的整数），硫代烷基团或硫代芳基团（式中Ar、Y和p如上所述），m和n各自为0至4的整数，但m和n不相等，且m+n为3至6的整数，并使用铝烷氧化物（B）。
• NOVEL VIRAL REPLICATION INHIBITORS
  申请人：Chaltin Patrick

  公开号：US20120129840A1

  公开（公告）日：2012-05-24

  The present invention relates to a series of novel compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to methods for the preparation of such compounds, as well as to novel intermediates useful in one or more steps of such syntheses. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. This invention further relates to the use of such compounds as medicines or in the manufacture of a medicament useful for the treatment of animals suffering from viral infections, in particular HIV infection. This invention further relates to methods for the treatment of viral infections in animals by the administration of a therapeutical amount of such compounds, optionally combined with one or more other drugs having antiviral activity.

  本发明涉及一系列具有抗病毒活性的新化合物，更具体地说是具有抑制HIV（人类免疫缺陷病毒）复制的特性。本发明还涉及制备这些化合物的方法，以及在这些合成的一个或多个步骤中有用的新中间体。本发明还涉及包含有效量这些化合物作为活性成分的药物组合物。本发明还涉及将这些化合物用作药物或制造用于治疗患有病毒感染的动物，特别是HIV感染的药物的用途。本发明还涉及通过给动物施用治疗量这些化合物的方法，可选地结合一种或多种具有抗病毒活性的其他药物，治疗动物的病毒感染。