十七烷酸酐 | 59252-36-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 十七烷酸酐
• 英文名称: heptadecanoic acid-anhydride
• 英文别名: Heptadecansaeure-anhydrid；Heptadecanoyl Heptadecanoate
• CAS: 59252-36-7
• 化学式: C₃₄H₆₆O₃
• mdl: MFCD00056219
• 分子量: 522.896
• InChiKey: KPELOSDOWOWZSG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.6
• 重原子数：
  37
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.941
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38

反应信息

• 作为反应物：
  描述：

  十七烷酸酐 、 4-amino-1-α-D-arabinopyranosyl-1H-pyrimidin-2-one 在 水 、 正己烷 、 乙酸乙酯 作用下， 以 水 为溶剂， 反应 5.0h， 以to provide 604 mg (1.22 m-mols) of N4 -margaroyl-1-β-D-arabinofuranosylcytosine (molecular weight 495) at a yield of 99.2% with a melting point of 144° to 147° C.的产率得到1-beta-D-阿拉伯呋喃糖基-4-十七碳酰氨基嘧啶-2(1H)-酮
  参考文献：
  名称：

  N.sup.4 -acylarabinonucleosides

  摘要：

  具有以下公式的N.sup.4-酰基-1-.beta.-D-阿拉伯呋喃核苷酸：##SPC1##其中，R是具有3到35个碳原子的脂肪族酰基基团。本发明化合物可用作癌症化疗药物，用于控制肿瘤，例如在小鼠中，也可用作杀虫剂和杀真菌表面活性剂。

  公开号：

  US03991045A1
• 作为产物：
  描述：

  十七烷酸 、 乙酸酐 生成 十七烷酸酐
  参考文献：
  名称：

  Anhydrides of the Normal Aliphatic Saturated Monobasic Acids

  摘要：

  DOI：

  10.1021/ja01848a017

文献信息

• METHOD FOR PREPARING 2,5-DISUBSTITUTED FURAN COMPOUND
  申请人：Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences

  公开号：US20170320844A1

  公开（公告）日：2017-11-09

  Disclosed is a method for preparing a 2,5-disubstituted furan compound. The 2,5-disubstituted furan compound is prepared in a simple, convenient and highly efficient way by reacting 2,3-dicarboxylic anhydride-7-oxabicyclo[2.2.1]hept-5-ene and/or furan with an acylating reagent and/or an alkylating reagent. The preparation method is simple and efficient, has a short process and less by-products, and the 2,5-disubstituted furan compound prepared by using the method has a high purity, and can satisfy the requirements for being used as a raw material for engineering plastics, such as high-performance polyesters, epoxy resins, polyamides, polyurethanes and the like, and as a chemical raw material and a pharmaceutical intermediate raw material.

  揭示了一种制备2,5-二取代呋喃化合物的方法。通过将2,3-二羧酸酐-7-氧杂双环[2.2.1]庚-5-烯和/或呋喃与酰化试剂和/或烷基化试剂反应，以简单、方便和高效的方式制备2,5-二取代呋喃化合物。该制备方法简单高效，过程短，副产物少，采用该方法制备的2,5-二取代呋喃化合物纯度高，可满足作为工程塑料原料（如高性能聚酯、环氧树脂、聚酰胺、聚氨酯等）和化工原料、药物中间体原料的要求。
• [EN] ALPHA HELIX MIMETICS AND METHODS RELATING THERETO<br/>[FR] MIMÉTIQUES D'HÉLICE ALPHA ET PROCÉDÉS S'Y RAPPORTANT
  申请人：PRISM BIOLAB CORP

  公开号：WO2012115286A1

  公开（公告）日：2012-08-30

  Alpha-helix mimetic structures and compounds represented by the formula (I) wherein the general formula and the definition of each symbol are as defined in the specification, a compound relating thereto, and methods relating thereto, are disclosed. Applications of these compounds in the treatment of medical conditions, e.g., cancer diseases, fibrotic diseases, and pharmaceutical compositions comprising the mimetics are further disclosed.

  α-螺旋拟态结构和由式(I)表示的化合物，其中一般式和每个符号的定义如规范中所定义，涉及的化合物以及涉及的方法被披露。还披露了这些化合物在治疗医疗状况（例如癌症疾病、纤维化疾病）中的应用，以及包含这些拟态体的药物组合物。
• [EN] NOVEL METHOD OF USE AND COMPOSITIONS<br/>[FR] NOUVEAU PROCÉDÉ D'UTILISATION ET COMPOSITIONS
  申请人：GLAXOSMITHKLINE CONSUMER HEALTHCARE HOLDINGS (US) LLC

  公开号：WO2017074902A1

  公开（公告）日：2017-05-04

  The present invention is directed to a method for improving the occlusiveness of a topical pharmaceutical or cosmetic formulation in use in a patient in need thereof, comprising adding to the formulation at least 0.1- to about 10% w/w of one or more of a monofatty acid ester of glycerin and/or one or more of a monofatty acid ester of glycol, or mixtures thereof. The present invention is also directed to a method for maintaining skin barrier efficiency of the stratum corneum of a patient in need thereof, comprising applying to the skin of said patient a pharmaceutical or cosmetic formulation containing at least 3 % w/w of one or more of a monofatty acid ester of glycerin and/or one or more of a monofatty acid ester of glycol, or mixtures thereof.

  本发明涉及一种用于改善患者使用中的局部药物或化妆品配方的闭合性的方法，包括向配方中添加至少0.1%至约10%重量/重量的一种或多种甘油的单脂肪酸酯和/或一种或多种乙二醇的单脂肪酸酯，或其混合物。本发明还涉及一种用于维持患者角质层皮肤屏障效率的方法，包括向该患者的皮肤上涂抹含有至少3%重量/重量的一种或多种甘油的单脂肪酸酯和/或一种或多种乙二醇的单脂肪酸酯，或其混合物的药物或化妆品配方。
• 5-Fluorouracil derivatives
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：US04088646A1

  公开（公告）日：1978-05-09

  A compound represented by the formulae: ##STR1## wherein R.sub.1 and R.sub.2 are as defined hereinafter, useful as an anti-cancer or anti-tumor agent.

  一种化合物，其化学式为：##STR1## 其中R.sub.1和R.sub.2如下定义，可用作抗癌或抗肿瘤剂。
• Cytidine nucleotide derivatives
  申请人：Asahi Kasei Kogyo Kabushiki Kaisha

  公开号：US04086417A1

  公开（公告）日：1978-04-25

  A nucleotide derivative represented by the general formula: ##STR1## wherein R represents an acyl group having 14 - 22 carbon atoms and having an aliphatic acyl moiety; X represents a hydrogen atom, a halogen atom, an alkyl group having 1 - 4 carbon atoms, or a trifluoromethyl group; and at least one, but not all, of Y.sub.1, Y.sub.2, and Y.sub.3 represents a phosphate, a pyrophosphate, a triphosphate, or a salt thereof, the balance of Y.sub.1, Y.sub.2 and Y.sub.3 representing a hydroxyl group; or in case of ribosyl, Y.sub.1 and Y.sub.3, or Y.sub.2 and Y.sub.3 represent, at the same time, the aforesaid phosphate, pyrophosphate, triphosphate or salt thereof and the remaining group of Y.sub.1, Y.sub.2 or Y.sub.3 represents a hydroxyl group; or in case of arabinosyl, Y.sub.1 and Y.sub.2, or Y.sub.2 and Y.sub.3 represent, at the same time, the aforesaid phosphate, pyrophosphate, triphosphate or salt therof and the remaining group of Y.sub.1, Y.sub.2 or Y.sub.3 represents a hydroxyl group. The nontoxic salts of these phosphates are useful as an antileukemialagent for mice which is soluble in water and has high stability.

  一种核苷酸衍生物，其通式表示为：##STR1## 其中R代表具有14-22个碳原子和具有脂肪族酰基的酰基基团；X代表氢原子、卤素原子、具有1-4个碳原子的烷基基团或三氟甲基基团；至少一个但不是全部的Y.sub.1、Y.sub.2和Y.sub.3代表磷酸盐、焦磷酸盐、三磷酸盐或其盐，Y.sub.1、Y.sub.2和Y.sub.3的平衡代表羟基；在核糖基的情况下，Y.sub.1和Y.sub.3，或者Y.sub.2和Y.sub.3同时代表上述磷酸盐、焦磷酸盐、三磷酸盐或其盐，而Y.sub.1、Y.sub.2或Y.sub.3的其余基团代表羟基；在阿拉伯糖基的情况下，Y.sub.1和Y.sub.2，或者Y.sub.2和Y.sub.3同时代表上述磷酸盐、焦磷酸盐、三磷酸盐或其盐，而Y.sub.1、Y.sub.2或Y.sub.3的其余基团代表羟基。这些磷酸盐的无毒盐在水中溶解并具有高稳定性，可用作小鼠的抗白血病剂。