十八碳-2-炔酸 | 2834-01-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 十八碳-2-炔酸
• 英文名称: KOA-18
• 英文别名: 2-octadecynoic acid；2-ODA；octadec-2-ynoic acid；octadecynoic acid；Δ²-Octadecinsaeure；Octadec-2-in-carbonsaeure
• CAS: 2834-01-7
• 化学式: C₁₈H₃₂O₂
• 分子量: 280.451
• InChiKey: WEAGGGHXTMXZQA-UHFFFAOYSA-N

物化性质

• 熔点：
  74°C (estimate)
• 沸点：
  433.28°C (rough estimate)
• 密度：
  0.9365 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  十八碳-2-炔酸 在 Lindlar's catalyst 吡啶 、 氢气 作用下， 生成 cis-Octadec-2-ensaeure
  参考文献：
  名称：

  Grimmer,G.; Hildebrandt,A., Justus Liebigs Annalen der Chemie, 1965, vol. 685, p. 154 - 160

  摘要：

  DOI：
• 作为产物：
  描述：

  溴代十五烷 、 丙炔酸 在 六甲基磷酰三胺 、 lithium diisopropyl amide 作用下， 生成 十八碳-2-炔酸
  参考文献：
  名称：

  Expedient synthesis of unsaturated amide alkaloids from Piper spp: Exploring the scope of recent methodology

  摘要：

  Sakai芳基醛-环酮Aldol-Grob断裂序列被扩展到肉桂醛和环己酮，并将产物改造为吡啶碱类似物。研究了涉及肉桂醛的反应中取代基的影响。当环辛酮或环丁酮替代环己酮或环戊酮时，苯甲醛无法进行Aldol-断裂序列，对此失败的原因进行了研究。对吡哆醛-环丁酮Aldol-断裂产物进行了四碳Wittig同系化，这是通往碱类如retrofractamide A的假设路线，但该方法并不可行。相反，利用Lu和Trost最近披露的炔化学，对易得的吡哆醛-环戊酮产物进行了三碳同系化，以极高的总产率制备了这些碱类。炔异构化还被用于高效合成辣椒碱和几种其他非芳香2E,4E-二烯酸Piper酰胺类碱类。关键词：Piper、酰胺、碱类、杀虫剂、Aldol、断裂、肉桂醛、炔、氧化还原、异构化。

  DOI：

  10.1139/v96-046

文献信息

• Microcapsules and process for producing them
  申请人：OHKAWARA KAKOHKI CO., LTD.

  公开号：EP0275358A1

  公开（公告）日：1988-07-27

  This process for producing microcapsules includes dissolving wax or a mixture of wax and protein in a mixed solvent consisting of an organic solvent and water, wetting, with the resulting solution, the surfaces of particles of a core substance at temperatures of 45 deg.C or below to selectively deposit the wax or the mixture of wax and protein on the particle surfaces and allow them to coat the particle surfaces. And then a slurry containing the particles are subjected to a solvent removal treatment.

  这种生产微胶囊的工艺包括将蜡或蜡与蛋白质的混合物溶解在由有机溶剂和水组成的混合溶剂中，在 45 摄氏度或更低的温度下用所得溶液润湿核心物质颗粒的表面，使蜡或蜡与蛋白质的混合物选择性地沉积在颗粒表面，并使它们包覆在颗粒表面。 然后对含有颗粒的浆液进行除溶剂处理。
• COMPOSITION FOR PROTECTION OF BODY SURFACE
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP1891924A1

  公开（公告）日：2008-02-27

  A body surface protecting composition, comprising at least one type of multi-chain multiple hydrophilic group-type compound having two or more hydrophobic groups and two or more hydrophilic groups in the molecule, which has an excellent effect of accelerating the recovery of the barrier function of skin and hair and preventing degradation of that function.

  一种体表保护组合物，包含至少一种多链多亲水基团型化合物，其分子中含有两个或两个以上的疏水基团和两个或两个以上的亲水基团，该组合物在加速恢复皮肤和头发的屏障功能以及防止该功能退化方面具有极佳的效果。
• DISPERSION LIQUID AND HYDROGEL FORMATION METHOD
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2865442A1

  公开（公告）日：2015-04-29

  There is provided a dispersion containing a lipid peptide type compound useful as a low molecular weight gelator, such as a lipid dipeptide and a lipid tripeptide, and a solvent capable of dissolving the lipid peptide type compound at a lower temperature more easily. There is provided also a dispersion from which a hydrogel can be formed by a simpler method and under a milder condition (low temperature) and from which a gel can be obtained as a gel having high thermal stability, and provide a method for forming the gel. A dispersion comprising a lipid peptide type compound in which a peptide portion having an amino acid repeating bonding structure is bonded to a lipid portion consisting of a C9-23 aliphatic group; and at least one alcohol selected from the group consisting of 1,2-alkanediol, 1,3-alkanediol, and ethylene glycol monoalkyl ether or a mixed solution of the at least one alcohol and water; and a method for producing a hydrogel by use of the dispersion.

  本发明提供了一种含有可用作低分子量凝胶剂的脂质肽类化合物（如脂质二肽和脂质三肽）的分散液，以及一种能够在较低温度下更容易溶解脂质肽类化合物的溶剂。本发明还提供了一种分散液，可通过更简单的方法在更温和的条件下（低温）形成水凝胶，并从中获得具有高热稳定性的凝胶，同时还提供了形成凝胶的方法。一种包含脂肽型化合物的分散液，其中具有氨基酸重复键合结构的肽部分与由 C9-23 脂肪族基团组成的脂质部分键合；以及至少一种选自 1,2-烷二醇、1,3-烷二醇和乙二醇单烷基醚或至少一种醇和水的混合溶液组成的组的醇，以及一种通过使用该分散液生产水凝胶的方法。
• DISPERSION AND METHOD FOR FORMING HYDROGEL
  申请人：NISSAN CHEMICAL INDUSTRIES, LTD.

  公开号：EP3296013A1

  公开（公告）日：2018-03-21

  There is provided a dispersion containing a lipid peptide type compound useful as a low molecular weight gelator, such as a lipid dipeptide and a lipid tripeptide, and a solvent capable of dissolving the lipid peptide type compound at a lower temperature more easily. There is provided also a dispersion from which a hydrogel can be formed by a simpler method and under a milder condition (low temperature) and from which a gel can be obtained as a gel having high thermal stability, and provide a method for forming the gel. A dispersion comprising a lipid peptide type compound in which a peptide portion having an amino acid repeating bonding structure is bonded to a lipid portion consisting of a C9-23 aliphatic group; and at least one alcohol selected from the group consisting of 1,2-alkanediol, 1,3-alkanediol, and ethylene glycol monoalkyl ether or a mixed solution of the at least one alcohol and water; and a method for producing a hydrogel by use of the dispersion.

  本发明提供了一种含有可用作低分子量凝胶剂的脂质肽类化合物（如脂质二肽和脂质三肽）的分散液，以及一种能够在较低温度下更容易溶解脂质肽类化合物的溶剂。本发明还提供了一种分散液，可通过更简单的方法在更温和的条件下（低温）形成水凝胶，并从中获得具有高热稳定性的凝胶，同时还提供了形成凝胶的方法。一种包含脂肽型化合物的分散液，其中具有氨基酸重复键合结构的肽部分与由 C9-23 脂肪族基团组成的脂质部分键合；以及至少一种选自 1,2-烷二醇、1,3-烷二醇和乙二醇单烷基醚或至少一种醇和水的混合溶液组成的组的醇，以及一种通过使用该分散液生产水凝胶的方法。
• COSMETIC COMPOSITION
  申请人：Rohto Pharmaceutical Co., Ltd.

  公开号：EP3616683A1

  公开（公告）日：2020-03-04

  Provided is a cosmetic composition that maintains high stability and restrains from becoming cloud. This cosmetic composition is prepared by including (A) polyoxyethylene polyoxypropylene glycol, and (B) an amino acid based surfactant having, in a single molecule thereof, two or more hydrophobic groups and two or more hydrophilic groups. Furthermore, provided is a method of giving a cloudiness-restraining effect to a cosmetic composition, including causing the component (A) and the component (B) to coexist with each other in the cosmetic composition.

  本发明提供了一种化妆品组合物，它能保持高稳定性并防止变浊。 这种化妆品组合物的制备方法是：(A) 聚氧乙烯聚氧丙烯二醇；(B) 氨基酸基表面活性剂，在其单个分子中具有两个或两个以上的疏水基团和两个或两个以上的亲水基团。此外，还提供了一种使化妆品组合物具有抑浊效果的方法，包括使组分（A）和组分（B）在化妆品组合物中共存。