十八碳-7-炔酸 | 19220-35-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 十八碳-7-炔酸
• 英文名称: octadec-7-ynoic acid
• 英文别名: Octadec-7-insaeure；Octadec-7-in-carbonsaeure；7-Octadecinsaeure；7-Octadecynsaeure；7-Octadecynoic acid
• CAS: 19220-35-0
• 化学式: C₁₈H₃₂O₂
• 分子量: 280.451
• InChiKey: XXUPLYBCNPLTIW-UHFFFAOYSA-N

物化性质

• 熔点：
  60.25°C (estimate)
• 沸点：
  433.28°C (rough estimate)
• 密度：
  0.9365 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  十八碳-7-炔酸 在 硝酸 作用下， 生成 7,8-dioxo-octadecanoic acid
  参考文献：
  名称：

  Posternak, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1916, vol. 162, p. 946

  摘要：

  DOI：
• 作为产物：
  描述：

  5-氯-1-戊醇 在 磷化氢 、 乙醇 、 氨 、 碘 、 potassium iodide 作用下， 生成 十八碳-7-炔酸
  参考文献：
  名称：

  Fusari; Greenlee; Brown, Journal of the American Oil Chemists' Society, 1951, vol. 28, p. 417

  摘要：

  DOI：

文献信息

• Efficient Synthesis of Unsaturated 1-Monoacyl Glycerols for in meso Crystallization of Membrane Proteins
  作者：Qinghai Zhang、Yu Fu、Yue Weng、Wen-Xu Hong

  DOI：10.1055/s-0030-1259912

  日期：2011.4

  A highly efficient synthesis of unsaturated 1-monoacyl glycerols was established to fulfill the pressing need for materials that form lipidic mesophases utilized in membrane protein crystallization.

  建立了高度有效的未饱和1-单酰甘油合成方法，以满足膜蛋白结晶中使用的脂质介晶材料迫切需要。
• Angiotensin-(1-7) and angiotensin-(1-7) agonists for inhibition of cancer cell growth
  申请人：——

  公开号：US20030203834A1

  公开（公告）日：2003-10-30

  The present invention describes the use of angiotensin-(1-7) peptide as an anti-cancer therapeutic. Thus, in one embodiment, the present invention comprises a composition to inhibit the growth of cancer cells in an individual comprising a pharmaceutically effective amount of an agonist for the angiotensin-(1-7) receptor to inhibit cancer cell growth or proliferation. Application of a pharmaceutically effective amount of angiotensin-(1-7) or angiotensin-(1-7) receptor agonist is associated with an increase in the expression of genes involved in tumor suppression, apoptosis, and/or cell cycle inhibition, and a decrease the expression of known oncogenes, protein kinases, and/or cell cycle progression genes. Cancers treated using the methods and compositions described herein include cancers having an angiotensin-(1-7) receptor, including, but not limited to, breast and lung cancer.

  本发明描述了血管紧张素-（1-7）肽作为抗癌疗法的用途。因此，在一个实施方案中，本发明包括一种抑制个体体内癌细胞生长的组合物，该组合物包含药学有效量的血管紧张素-（1-7）受体激动剂，以抑制癌细胞生长或增殖。应用药学有效量的血管紧张素-（1-7）或血管紧张素-（1-7）受体激动剂与参与肿瘤抑制、细胞凋亡和/或细胞周期抑制的基因表达增加以及已知致癌基因、蛋白激酶和/或细胞周期进展基因表达减少有关。使用本文所述方法和组合物治疗的癌症包括具有血管紧张素-（1-7）受体的癌症，包括但不限于乳腺癌和肺癌。
• Device and methods for modifying an atmosphere
  申请人：——

  公开号：US20040047760A1

  公开（公告）日：2004-03-11

  The present invention provides a device for modifying an atmosphere in proximity to the device, the device comprising a sachet comprising a semipermeable material, and a composition including a mixture of acetylsalicylic acid and sodium bicarbonate contained within a cavity of the sachet. The invention further provides methods for modifying an atmosphere comprising placing a mixture of a carboxylic acid and a base in the atmosphere, wherein the atmosphere has a sufficient level of water vapor such that, upon contact of the water vapor with the mixture, carbon dioxide is produced.

  本发明提供了一种用于改变靠近该装置的大气环境的装置，该装置包括一个由半透材料组成的小袋，以及一个包含在小袋空腔内的乙酰水杨酸和碳酸氢钠混合物的组合物。本发明进一步提供了改变大气环境的方法，包括将羧酸和碱的混合物置于大气中，其中大气中的水蒸气含量足够高，当水蒸气与混合物接触时，会产生二氧化碳。
• CO2 generating absorbent pads
  申请人：CO2 Technologies, Inc.

  公开号：US20040247750A1

  公开（公告）日：2004-12-09

  A method and means for enhancing the inner environment of a package containing perishable merchandise include taking a closable package containing perishable merchandise and placing in the package a multi-layered sheet including a plurality of layers comprised of moisture absorbing materials to absorb any residual moisture emanating from the perishable merchandise. The multi-layered sheet includes a quantity of CO 2 generating material incorporated therein. The CO 2 generating material is exposable to humidity and any residual moisture within the package and any moisture absorbing material to allow the CO 2 generating material to emit an atmosphere of CO 2 within the package from exposure to moisture within the air in the package, and to absorb any residual moisture in the package.

  一种用于改善装有易腐商品的包装内部环境的方法和装置，包括取一个装有易腐商品的可封闭包装，并在包装内放置一个多层薄片，该多层薄片包括由吸湿材料组成的多层，以吸收易腐商品散发出的任何残余湿气。多层板包括一定量的 CO 2 生成材料。二氧化碳 2 生成材料可暴露于湿度、包装内的任何残留湿气以及任何吸湿材料中，使 CO 2 生成材料释放出二氧化碳气体。 2 并吸收包装内的任何残留湿气。
• Active masterbatch for production of CO2 generating masterbatch
  申请人：Finnegan J. Michael

  公开号：US20050001204A1

  公开（公告）日：2005-01-06

  A compound permitting the economic production of packaging containers, which when activated produces concentrated amounts of CO2 gas for extended periods for preservation of perishable products therein, comprises a mixture including a CO2 generating portion incorporated within a polymer matrix. Preferably, the mixture includes citric acid; calcium carbonate, and polyethylene resin. More preferably, the mixture includes a mixture of a carboxylic acid (0.1-40%); a hydrogen carbonate (0.1-40%) and any polyolefin resin. Even more preferably, the mixture includes a mixture including (0.01-40%) Citric Acid; (0.01-40%); and 30-75% polyethylene resin. Most preferably, the mixture includes by weight 12% citric acid; 38% calcium carbonate; and 50% low density polyethylene resin with a melt index of 20 and a density of 0.924 g/cc. Alternatively, the carboxylic acid and hydrogen carbonate components are compounded into separate polymer matrixes, and later combined. The compound may be packaged in containers that are formed of flexible or rigid material.