十六碳二烯酸 | 20261-45-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 十六碳二烯酸
• 英文名称: 9,12-Hexadecadienoic acid
• 英文别名: (9E,12E)-hexadeca-9,12-dienoic acid
• CAS: 20261-45-4
• 化学式: C₁₆H₂₈O₂
• 分子量: 252.39
• InChiKey: RVEKLXYYCHAMDF-AOSYACOCSA-N

物化性质

• 沸点：
  345.4±11.0 °C(Predicted)
• 密度：
  0.919±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  18
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 海关编码：
  2916190090

文献信息

• [EN] HYDROCARBON SYNTHESIS METHODS, APPARATUS, AND SYSTEMS<br/>[FR] PROCÉDÉS, APPAREIL ET SYSTÈMES DE SYNTHÈSE D'HYDROCARBURES
  申请人：MCNEFF CLAYTON V

  公开号：WO2014008355A1

  公开（公告）日：2014-01-09

  Embodiments of the invention include apparatus and systems for hydrocarbon synthesis and methods regarding the same. In an embodiment, the invention includes a process for creating a hydrocarbon product stream comprising reacting a reaction mixture in the presence of a catalyst inside of a reaction vessel to form a product mixture, the reaction mixture comprising a carbon source and water. The temperature inside the reaction vessel can be between 450 degrees Celsius and 600 degrees Celsius and the pressure inside the reaction vessel can be above supercritical pressure for water. In an embodiment, the invention includes an extrusion reactor system for creating a hydrocarbon product stream. The temperature inside the extrusion reactor housing between 450 degrees Celsius and 600 degrees Celsius. Pressure inside the reaction vessel can be above supercritical pressure for water. Other embodiments are also included herein.

  本发明的实施例包括用于合成碳氢化合物的设备和系统以及相关方法。在一种实施例中，本发明包括一种用于创建碳氢化合物产品流的过程，其中在反应容器内，在催化剂的存在下，反应混合物以形成产物混合物，反应混合物包括碳源和水。反应容器内的温度可在450摄氏度至600摄氏度之间，反应容器内的压力可高于水的超临界压力。在一种实施例中，本发明包括一种挤出反应器系统，用于创建碳氢化合物产品流。挤出反应器壳体内的温度在450摄氏度至600摄氏度之间。反应容器内的压力可高于水的超临界压力。本发明还包括其他实施例。
• Genes participating in the synthesis of fatty acid having trans-11-,cis-13-conjugated double bond and utilization thereof
  申请人：Osumi Mari

  公开号：US20050108788A1

  公开（公告）日：2005-05-19

  An object of the present invention is to clone a gene which is involved in synthesis of fatty acid having trans-11-, cis-13-conjugated double bonds from fatty acid having a double bone at position Δ12. The present invention provides a gene having any one of the following nucleotide sequences: (A) a nucleotide sequence encoding an amino acid sequence shown in SEQ ID NO: 1 or 12; (B) a nucleotide sequence encoding an amino acid sequence comprising a deletion, addition or substitution of one or several amino acids with respect to the amino acid sequence shown in SEQ NO: 1 or 12, and having an ability of synthesizing fatty acid having trans-11-, cis-13-conjugated double bonds from fatty acid having a double bond at position Δ12; (C) a nucleotide sequence shown in SEQ ID NO: 2 or 13; (D) a nucleotide sequence comprising a deletion, addition or substitution of one or several nucleotides with respect to the nucleotide sequence shown in SEQ ID NO: 2 or 13, and encoding a protein having an ability of synthesizing fatty acid having trans-11-, cis-13-conjugated double bonds from fatty acid having a double bond at position Δ12; and (E) a nucleotide sequence hybridizing with the nucleotide sequence shown in SEQ ID NO: 2 or 13 or a complementary sequence thereof under stringent conditions, and encoding a protein having an ability of synthesizing fatty acid having trans-11-, cis-13-conjugated double bonds from fatty acid having a double bond at position Δ12.

  本发明的目的是克隆参与合成具有位置Δ12处双键的脂肪酸中具有反11-顺13-共轭双键的基因。本发明提供了具有以下任一核苷酸序列的基因：(A)编码SEQ ID NO:1或12中所示氨基酸序列的核苷酸序列；(B)编码与SEQ NO:1或12中所示氨基酸序列相比具有一个或多个氨基酸的缺失、添加或置换，并具有从位置Δ12处具有双键的脂肪酸合成反11-顺13-共轭双键的能力的氨基酸序列的核苷酸序列；(C) SEQ ID NO:2或13所示的核苷酸序列；(D)与SEQ ID NO:2或13所示的核苷酸序列相比具有一个或多个核苷酸的缺失、添加或置换，并编码具有从位置Δ12处具有双键的脂肪酸合成反11-顺13-共轭双键的能力的蛋白质的核苷酸序列；以及(E)在严格条件下与SEQ ID NO:2或13所示的核苷酸序列或其互补序列杂交，并编码具有从位置Δ12处具有双键的脂肪酸合成反11-顺13-共轭双键的能力的蛋白质的核苷酸序列。
• Cationic cardiolipin analoges and its use thereof
  申请人：Ahmad U. Moghis

  公开号：US20050277611A1

  公开（公告）日：2005-12-15

  The invention provides cationic cardiolipin compounds, and methods for synthesizing and using them in liposomal formulation, gene transfection, etc. In particular, the invention provides liposomes comprising cationic cardiolipin analog, pharmaceutical compositions comprising cationic cardiolipin analogs, and methods of using such liposomes and compositions, in delivering active pharmaceutical agents to treat human and animal diseases and/or in diagnostic assays.

  本发明提供了阳离子心磷脂化合物以及其合成和在脂质体制剂、基因转染等方面的使用方法。特别地，本发明提供了含阳离子心磷脂类似物的脂质体、含阳离子心磷脂类似物的药物组合物以及使用这些脂质体和组合物的方法，用于传递活性药物治疗人类和动物疾病和/或诊断测定。
• Cardiolipin molecules and methods of synthesis
  申请人：Ahmad U. Moghis

  公开号：US20050266068A1

  公开（公告）日：2005-12-01

  The invention provides new synthetic routes for cardiolipin with different fatty acids and/or alkyl chains with varying chain length and also with or without unsaturation, particularly a short-chain cardiolipin. The methods comprise reacting a 1,2-O-sn-diacyl/1,2-O-sn-dialkyl glycerol or a 2-O-protected glycerol, with a phosphoramidite reagent or a phosphate triester to produce a protected cardiolipin, which is deprotected to prepare the short chain cardiolipin. The reaction schemes can be used to generate new variants of cardiolipin. The cardiolipin prepared by the present methods can be incorporated into liposomes, which can also include active agents such as hydrophobic or hydrophilic drugs. Such liposomes can be used to treat diseases or in diagnostic and/or analytical assays. Liposomes can also include ligands for targeting a particular cell type or specific tissue.

  本发明提供了一种合成不同脂肪酸和/或不同链长烷基的心磷脂的新合成路线，以及具有或不具有不饱和度，特别是一种短链心磷脂。该方法包括将1,2-O-sn-二酰基/1,2-O-sn-二烷基甘油或2-O-保护甘油与磷酸酰胺试剂或磷酸三酯反应以产生受保护的心磷脂，然后去保护以制备短链心磷脂。该反应方案可用于生成心磷脂的新变体。通过本方法制备的心磷脂可以被纳入到脂质体中，这些脂质体还可以包括疏水性或亲水性药物等活性剂。这样的脂质体可以用于治疗疾病或在诊断和/或分析检测中使用。脂质体还可以包括用于靶向特定细胞类型或特定组织的配体。
• Cardiolipin compositions their methods of preparation and use
  申请人：Ahmad U. Moghis

  公开号：US20050181037A1

  公开（公告）日：2005-08-18

  The invention provides new synthetic routes for cardiolipin with different fatty acids and/or alkyl chains with varying chain length and also with or without unsaturation. The reaction schemes can be used to generate new forms of cardiolipin, including cardiolipin variants. The cardiolipin prepared by the present methods can conveniently be incorporated into liposomes and other lipid formulations that can also include active agents such as hydrophobic or hydrophilic drugs. Such formulations can be used to treat diseases or in diagnostic and/or analytical assays. Liposomes also can include ligands, e.g., for targeting them to a cell type or specific tissue.

  本发明提供了一种用于合成不同脂肪酸和/或不同碳链长度以及有或没有不饱和度的磷脂酰肌醇的新合成路线。反应方案可用于生成新形式的磷脂酰肌醇，包括磷脂酰肌醇变异体。通过本方法制备的磷脂酰肌醇可以方便地被纳入脂质体和其他脂质制剂中，这些制剂也可以包括疏水性或亲水性药物等活性剂。这样的制剂可用于治疗疾病或在诊断和/或分析测定中使用。脂质体还可以包括配体，例如用于将其定向到特定细胞类型或组织的配体。