3-hexyl-1,2,4,5-tetroxocane

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机氧化物
• 英文名称: 3-hexyl-1,2,4,5-tetroxocane
• 英文别名: 3-Hexyl-1,2,4,5-tetraoxocane
• 化学式: C₁₀H₂₀O₄
• 分子量: 204.266
• InChiKey: VOPHCYKHRWXION-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  辛烯 在 双氧水 、 臭氧 、 silver(l) oxide 作用下， 以 乙醚 、 乙酸乙酯 为溶剂， 反应 0.15h， 生成 3-hexyl-1,2,4,5-tetroxocane
  参考文献：
  名称：

  Synthesis and Antimalarial Activity of Novel Medium-Sized 1,2,4,5-Tetraoxacycloalkanes

  摘要：

  CsOH- or Ag2O-mediated cycloalkylation of (alkylidene)bisperoxides 3 and 1,n.-dihaloalkanes (n = 3-8) provided the corresponding medium-sized 1,2,4,5-tetraoxacycloalkanes 4-8 in moderate yields. Subsequent evaluation of the antimalarial activity of the cyclic peroxides 4-8 in vitro and in vivo revealed that 1,2,6,7-tetraoxaspiro [7.11]nonadecane 4a has considerable potential as a new, inexpensive, and potent antimalarial drug.

  DOI：

  10.1021/jm010026g

文献信息

• Synthesis and Antimalarial Activity of Novel Medium-Sized 1,2,4,5-Tetraoxacycloalkanes
  作者：Hye-Sook Kim、Yukiko Nagai、Kanako Ono、Khurshida Begum、Yusuke Wataya、Yoshiaki Hamada、Kaoru Tsuchiya、Araki Masuyama、Masatomo Nojima、Kevin J. McCullough

  DOI：10.1021/jm010026g

  日期：2001.7.1

  CsOH- or Ag2O-mediated cycloalkylation of (alkylidene)bisperoxides 3 and 1,n.-dihaloalkanes (n = 3-8) provided the corresponding medium-sized 1,2,4,5-tetraoxacycloalkanes 4-8 in moderate yields. Subsequent evaluation of the antimalarial activity of the cyclic peroxides 4-8 in vitro and in vivo revealed that 1,2,6,7-tetraoxaspiro [7.11]nonadecane 4a has considerable potential as a new, inexpensive, and potent antimalarial drug.