α-hydroperoxyheptyl hydroperoxide

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机氢过氧化物
• 英文名称: α-hydroperoxyheptyl hydroperoxide
• 英文别名: 1,1-Dihydroperoxyheptane
• 化学式: C₇H₁₆O₄
• 分子量: 164.202
• InChiKey: UYROAKKLXKSHOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  58.9
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,3-二碘丙烷 、 α-hydroperoxyheptyl hydroperoxide 在 silver(l) oxide 作用下， 以 乙酸乙酯 为溶剂， 以32%的产率得到3-hexyl-1,2,4,5-tetroxocane
  参考文献：
  名称：

  Synthesis and Antimalarial Activity of Novel Medium-Sized 1,2,4,5-Tetraoxacycloalkanes

  摘要：

  CsOH- or Ag2O-mediated cycloalkylation of (alkylidene)bisperoxides 3 and 1,n.-dihaloalkanes (n = 3-8) provided the corresponding medium-sized 1,2,4,5-tetraoxacycloalkanes 4-8 in moderate yields. Subsequent evaluation of the antimalarial activity of the cyclic peroxides 4-8 in vitro and in vivo revealed that 1,2,6,7-tetraoxaspiro [7.11]nonadecane 4a has considerable potential as a new, inexpensive, and potent antimalarial drug.

  DOI：

  10.1021/jm010026g
• 作为产物：
  描述：

  庚醛 在 双氧水 作用下， 以 水 、 乙腈 为溶剂， 反应 8.0h， 以76%的产率得到α-hydroperoxyheptyl hydroperoxide
  参考文献：
  名称：

  三氟甲磺酸功能化二氧化硅涂布的磁性纳米粒子作为一磁性可分离催化剂合成宝石-Dihydroperoxides

  摘要：

  三氟甲磺酸官能化的二氧化硅涂覆的磁性纳米颗粒[γ-的Fe 2 ö 3 @SiO 2 -TfOH]被容易地制备和鉴定为醛或酮为它们相应的转化的催化剂effictive宝石-dihydroperoxides用30％过氧化氢水溶液。通过磁倾析容易地分离催化剂，并且回收的催化剂在没有明显损失催化活性的情况下重复使用七个循环。

  DOI：

  10.1002/adsc.201100561

文献信息

• Synthesis and Antimalarial Activity of Novel Medium-Sized 1,2,4,5-Tetraoxacycloalkanes
  作者：Hye-Sook Kim、Yukiko Nagai、Kanako Ono、Khurshida Begum、Yusuke Wataya、Yoshiaki Hamada、Kaoru Tsuchiya、Araki Masuyama、Masatomo Nojima、Kevin J. McCullough

  DOI：10.1021/jm010026g

  日期：2001.7.1

  CsOH- or Ag2O-mediated cycloalkylation of (alkylidene)bisperoxides 3 and 1,n.-dihaloalkanes (n = 3-8) provided the corresponding medium-sized 1,2,4,5-tetraoxacycloalkanes 4-8 in moderate yields. Subsequent evaluation of the antimalarial activity of the cyclic peroxides 4-8 in vitro and in vivo revealed that 1,2,6,7-tetraoxaspiro [7.11]nonadecane 4a has considerable potential as a new, inexpensive, and potent antimalarial drug.
• Triflic Acid-Functionalized Silica-Coated Magnetic Nanoparticles as a Magnetically Separable Catalyst for Synthesis of gem-Dihydroperoxides
  作者：Yong-Hui Liu、Jia Deng、Jian-Wu Gao、Zhan-Hui Zhang

  DOI：10.1002/adsc.201100561

  日期：2012.2

  Triflic acid-functionalized silica-coated magnetic nanoparticles [γ-Fe2O3@SiO2-TfOH] were readily prepared and identified as an effictive catalyst for the transformation of aldehydes or ketones into their corresponding gem-dihydroperoxides with 30% aqueous hydrogen peroxide. The catalyst was easily separated by magnetic decantation and the recovered catalyst was reused for seven cycles without significant

  三氟甲磺酸官能化的二氧化硅涂覆的磁性纳米颗粒[γ-的Fe 2 ö 3 @SiO 2 -TfOH]被容易地制备和鉴定为醛或酮为它们相应的转化的催化剂effictive宝石-dihydroperoxides用30％过氧化氢水溶液。通过磁倾析容易地分离催化剂，并且回收的催化剂在没有明显损失催化活性的情况下重复使用七个循环。