2-{2,4-dimethoxyphenyl}-3-nitropyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-{2,4-dimethoxyphenyl}-3-nitropyridine
• 英文别名: 2-(2,4-Dimethoxyphenyl)-3-nitropyridine
• 化学式: C₁₃H₁₂N₂O₄
• 分子量: 260.249
• InChiKey: MTBKCVLBUOTOCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  77.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氯-3-硝基吡啶 、 间苯二甲醚 在 三氯化铝 作用下， 以 1,2-二氯乙烷 为溶剂， 反应 24.0h， 以41%的产率得到2-{2,4-dimethoxyphenyl}-3-nitropyridine
  参考文献：
  名称：

  A New Synthesis of 2-Substituted Pyridines via Aluminum Chloride Induced Heteroarylation of Arenes and Heteroarenes

  摘要：

  We herein report a new synthesis of 2-(hetero)aryl-substituted pyridines via heteroarylation of arenes/heteroarenes through. AlCl3-induced C-C bond-forming reactions. 2-Halopyridines bearing an electron-withdrawing group were reacted with a number of (hetero)arenes to give 2-aryl/heteroaryl-substituted pyridines in good yields.

  DOI：

  10.1021/jo047944h

文献信息

• A New Synthesis of 2-Substituted Pyridines via Aluminum Chloride Induced Heteroarylation of Arenes and Heteroarenes
  作者：Manojit Pal、Venkateswara Rao Batchu、Indu Dager、Nalivela Kumara Swamy、Srinivas Padakanti

  DOI：10.1021/jo047944h

  日期：2005.3.1

  We herein report a new synthesis of 2-(hetero)aryl-substituted pyridines via heteroarylation of arenes/heteroarenes through. AlCl3-induced C-C bond-forming reactions. 2-Halopyridines bearing an electron-withdrawing group were reacted with a number of (hetero)arenes to give 2-aryl/heteroaryl-substituted pyridines in good yields.