1-methyl-4-(carbazol-9-yl)-1,2,3,4-tetrahydroquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-methyl-4-(carbazol-9-yl)-1,2,3,4-tetrahydroquinoline
• 英文别名: 9-(1-methyl-3,4-dihydro-2H-quinolin-4-yl)carbazole
• 化学式: C₂₂H₂₀N₂
• 分子量: 312.414
• InChiKey: MMYUZPIXYAUCKO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  8.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-乙烯基咔唑 、 N-甲基-N-苯基苯并三唑甲胺 反应 2.5h， 以53%的产率得到1-methyl-4-(carbazol-9-yl)-1,2,3,4-tetrahydroquinoline
  参考文献：
  名称：

  Additions of 1-(aminomethyl)benzotriazoles to enamines, enamides, and vinyl ethers: novel routes to 1,3-diamines and tetrahydroquinolines

  摘要：

  New methods for the synthesis of 1,3-diamines and of 4-substituted tetrahydroquinolines are described in which the key step is the addition of the condensation products derived from amines, aldehydes, and benzotriazole to enamines, enamides, and vinyl ethers.

  DOI：

  10.1021/jo00056a006

文献信息

• Additions of 1-(aminomethyl)benzotriazoles to enamines, enamides, and vinyl ethers: novel routes to 1,3-diamines and tetrahydroquinolines
  作者：Alan R. Katritzky、Bogumila Rachwal、Stanislaw Rachwal

  DOI：10.1021/jo00056a006

  日期：1993.2

  New methods for the synthesis of 1,3-diamines and of 4-substituted tetrahydroquinolines are described in which the key step is the addition of the condensation products derived from amines, aldehydes, and benzotriazole to enamines, enamides, and vinyl ethers.