2-(dimethylamino)pyridinium p-toluenesulfonate

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(dimethylamino)pyridinium p-toluenesulfonate
• 英文别名: DPTS；N,N-dimethylpyridin-1-ium-2-amine;4-methylbenzenesulfonate
• 化学式: C₇H₈O₃S*C₇H₁₀N₂
• 分子量: 294.375
• InChiKey: QHFSFXIJOPKPMS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.39
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  78.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-萘甲酸 、 甲基丙烯酸羟乙酯 、 2-(dimethylamino)pyridinium p-toluenesulfonate 、 N,N'-二环己基碳二亚胺 在 氮气 、 尿素 、 盐酸 、 碳酸氢钠 、 水 、 Brine 、 Sodium sulfate-III 作用下， 以 二氯甲烷 为溶剂， 反应 3.25h， 以to provide 8.2 g (62% of theory) of a pale yellow oil的产率得到2-(1-naphthoyloxy)ethyl methacrylate
  参考文献：
  名称：

  Optical recording media with triplet-sensitized isomerization

  摘要：

  本发明涉及一种光记录材料，包括：聚合物基体；一种能够在三重激发下发生异构化反应生成苯产物的二茂苯衍生物反应物，从而引起光学性能的变化；以及一种能够吸收光致辐射并将三重能量传递至所述反应物的敏化剂，其中所述敏化剂的激发能量和还原电位的代数和至少比所述反应物的氧化电位低0.05电子伏特，从而防止所述反应物发生单电子氧化。本发明还涉及一种光学器件，其包括由三重链异构化产生的反应物和产物浓度的区域变化，从而提供智能图案。

  公开号：

  US07459263B2
• 作为产物：
  描述：

  2-二甲氨基吡啶 、 对甲苯磺酸 以 四氢呋喃 为溶剂， 以50%的产率得到2-(dimethylamino)pyridinium p-toluenesulfonate
  参考文献：
  名称：

  铜介导的萘甲酸萘酚硼酸酯的放射性氟化：使用吡啶鎓磺酸盐的简便方法

  摘要：

  这项工作首次证明了吡啶鎓磺酸盐（有机溶液）在产生反应性[ 18 F]氟化物方面的应用，以及在铜介导的芳基pinacoloboronate酯的放射性氟化中的有效应用。已针对8种芳香族底物证明了该方法的可行性。

  DOI：

  10.1002/ejoc.201801514
• 作为试剂：
  描述：

  1,1,1-三(羟甲基)乙烷 、 6-oxo-6-(2-thioxothiazolidin-3-yl)hexanoic acid 在 2-(dimethylamino)pyridinium p-toluenesulfonate 、 N,N'-二环己基碳二亚胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 16.0h， 以67.2%的产率得到3-hydroxy-2-(hydroxymethyl)-2-methylpropyl 6-oxo-6(2-thioxothiazolidin-3-yl)hexanoate
  参考文献：
  名称：

  Synthesis, Characterization, and Bioactivity of Mid-Functional PolyHPMA−Lysozyme Bioconjugates

  摘要：

  A thiazolidine-2-thione mid-functionalized chain transfer agent (CTA) was synthesized and used as a reversible addition fragmentation chain transfer (RAFT) polymerization agent to prepare poly(N-(2-hydroxypropyl)methacrylamide) (polyHPMA) with mid-chain thiazolidine-2-thione functionality. The synthesized polymers were fully analyzed by H-1 NMR and GPC, confirming well-defined structures (predesigned molecular weights, narrow polydispersities, and high functionalization efficiencies). A subsequent hydrolysis/analysis of the polymers was performed to verify their mid-functional structures. These mid-functionalized polymers were then incubated with a model protein (lysozyme) to generate branched polymer protein bioconjugates. The bioactivity of the branched polymer protein conjugate was tested and compared to similar molecular weight linear polyHPMA-protein bioconjugate; the branched polymer protein conjugate remained much more protein activity, indicating the mid-chain-functional polyHPMA was more selective in its conjugation reaction on the lysozyme surface when compared with conjugation reactions involving terminal-functional polyHPMA. This straightforward methodology, described herein, for the synthesis of branched polymer protein bioconjugates strikes a balance between protein protection by the attachment of polymer chains and the subsequent bioactivity retention of the bioconjugate.

  DOI：

  10.1021/ma100142w

文献信息

• [EN] CLEAVABLE ESTERS FOR NANOCARRIER-BASED CANCER THERAPY<br/>[FR] ESTERS CLIVABLES POUR UNE THÉRAPIE ANTICANCÉREUSE BASÉE SUR DES NANOVECTEURS
  申请人：CHILDRENS HOSPITAL PHILADELPHIA

  公开号：WO2018169934A1

  公开（公告）日：2018-09-20

  Aco-drug is represented by Formula (I) or Formula (II), R-X-NH-CO-CO-OR1 (I) R-X-CO-O-CH2-CO-OR1 (II) where R is a tocol moiety, a tocol analog moiety, or a capsaicinoid moiety; X is a direct bond or a linking group; and OR1 is the residue of an anticancer or antirestenotic agent bearing at least one hydroxyl group by which the CO-OR1 ester linkage is formed. Nanoparticles that include the abovementioned co-drug are also provided, as well as a method of treating a cancer patient that includes administering an effective amount of the co-drug or nanoparticles.

  Aco-drug由公式（I）或公式（II）表示，其中R-X-NH-CO-CO-OR1（I）R-X-CO-O-CH2-CO-OR1（II），其中R是生育酚基团，生育酚类似物基团或辣椒素基团；X是直接键或连接基团；OR1是至少带有一个羟基的抗癌或抗再狭窄剂的残基，通过CO-OR1酯键形成。还提供包括上述共药物的纳米粒子，以及一种治疗癌症患者的方法，包括给予有效剂量的共药物或纳米粒子。
• Optical recording media with triplet-sensitzed isomerization
  申请人：Farid Y. Samir

  公开号：US20050136357A1

  公开（公告）日：2005-06-23

  The invention relates to an optical recording material comprising: a polymeric matrix; a dewarbenzene derivative reactant capable of undergoing isomerization to a benzene product upon triplet excitation, thereby causing a change in optical properties; and a sensitizer capable of absorbing actinic radiation to cause triplet energy transfer to said reactant, wherein the algebraic sum of the excitation energy of said sensitizer and its reduction potential is at least 0.05 eV less than the oxidation potential of said reactant, thereby precluding one-electron oxidation of said reactant. The invention further relates to an optical device comprising regional variations in concentrations of reactants and products produced by triplet chain isomerization, thereby providing a pattern of intelligence.

  本发明涉及一种光记录材料，包括：聚合物基质；一种能够在三重激发下发生异构化为苯产物的二茂苯衍生物反应物，从而引起光学性质的变化；以及一种敏化剂，能够吸收光致辐射，使三重能量传递到所述反应物，其中所述敏化剂的激发能和还原电位的代数和至少比所述反应物的氧化电位低0.05 eV，从而排除了所述反应物的单电子氧化。本发明还涉及一种光学装置，其中包括由三重链异构化产生的反应物和产物浓度的区域变化，从而提供智能图案。
• MATERIAL FOR HOT MELT EXTRUSION SYSTEM, MODELING MATERIAL FOR 3D PRINTERS, METHOD FOR PRODUCING MODELING MATERIAL FOR 3D PRINTERS, AND THREE-DIMENSIONAL MODEL
  申请人：KONICA MINOLTA, INC.

  公开号：EP3875525A1

  公开（公告）日：2021-09-08

  The present invention addresses the problem of providing: a material for hot melt extrusion system, which has excellent elastic modulus, while forming a model that has excellent dimensional stability under high temperature high humidity conditions; a modeling material for 3D printers; a method for producing a modeling material for 3D printers; and a three-dimensional model. A material for hot melt extrusion system according to the present invention contains at least a cellulose derivative and an additive, and is characterized in that: the cellulose derivative is a cellulose acetate propionate and satisfies formula (1) and formula (2), wherein X is the degree of substitution of acetyl groups and Y is the degree of substitution of propionyl groups; and the additive contains a plasticizer and a compound A having a partial structure that has an NICS value within the range of from -14 to -10 (inclusive). Formula (1): 2.0 ≤ X + Y ≤ 3.0, Formula (2): 0.5 ≤ Y ≤ 2.6.

  本发明所要解决的问题是提供：一种热熔挤出系统用材料，该材料具有优异的弹性模量，同时在高温高湿条件下形成的模型具有优异的尺寸稳定性；一种用于三维打印机的建模材料；一种用于三维打印机的建模材料的生产方法；以及一种三维模型。根据本发明的一种用于热熔挤出系统的材料至少含有一种纤维素衍生物和一种添加剂，其特征在于：纤维素衍生物是一种乙酸丙酸纤维素，满足式（1）和式（2），其中X是乙酰基的取代度，Y是丙酰基的取代度；添加剂含有一种增塑剂和一种化合物A，其部分结构的NICS值在-14至-10（含）的范围内。式 (1)：2.0 ≤ X + Y ≤ 3.0, 式 (2)：0.5 ≤ Y ≤ 2.6.
• Crosslinkable compound, method for preparing the same and light emitting device comprising the same
  申请人：BOE Technology Group Co., Ltd.

  公开号：EP2743253B1

  公开（公告）日：2016-03-09
• SUBSTITUTED POLYCAPROLACTONE FOR COATING
  申请人：Abbott Cardiovascular Systems Inc.

  公开号：EP2162503A1

  公开（公告）日：2010-03-17