N,N dimethylformamide (dimethylformamide)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N dimethylformamide (dimethylformamide)
• 英文别名: DMF Dimethylformamide；N,N-dimethylformamide;N-methylacetamide
• 化学式: C₃H₇NO*C₃H₇NO
• 分子量: 146.189
• InChiKey: WNBOCZIREHOPCH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.54
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  49.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  草酰氯 、 N,N dimethylformamide (dimethylformamide) 、 3-乙氧基-异香草酸 在 三氯化铝 磷酸 作用下， 以 邻苯二甲醚 、 二氯甲烷 为溶剂， 以0.8 g (51%)的产率得到3,4-dimethoxy-3-ethoxy-4-methoxybenzophenone
  参考文献：
  名称：

  Immunotherapeutic agents

  摘要：

  取代苯乙烯的氰基和羧基衍生物是肿瘤坏死因子 .alpha.、核因子 .kappa.B 和磷酸二酯酶的抑制剂，可用于对抗消瘦症、内毒素休克、逆转录病毒复制、哮喘和炎症性疾病。一个典型的实施例是3,3-双-(3,4-二甲氧基苯基)丙烯腈。

  公开号：

  US05929117A1

文献信息

• Nitrogen-containing aromatic derivatives
  申请人：——

  公开号：US20040053908A1

  公开（公告）日：2004-03-18

  Compounds represented by the following general formula: 1 [wherein A g is an optionally substituted 5- to 14-membered heterocyclic group, etc.; X g is —O—, —S—, etc.; Y g is an optionally substituted C 6 - 14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and T g1 is a group represented by the following general formula: 2 (wherein E g is a single bond or —N(R g2 )—, R g1 and R g2 each independently represent a hydrogen atom, an optionally substituted C 1-6 alkyl group, etc. and Z g represents a C 1-8 alkyl group, a C 3-8 alicyclic hydrocarbon group, a C 6-14 aryl group, etc.)], salts thereof or hydrates of the foregoing.

  由以下一般式表示的化合物： 1 [其中 A g 是可选择地取代的5-至14-成员杂环基团，等等；X g 是—O—，—S—，等等；Y g 是可选择地取代的C 6 - 14 芳基团，可选择地取代的5-至14-成员杂环基团，等等；以及 T g1 是由以下一般式表示的基团： 2 [其中 E g 是单键或—N(R g2 )—，R g1 和R g2 各自独立地表示氢原子，可选择地取代的C 1-6 烷基基团，等等，Z g 表示C 1-8 烷基基团，C 3-8 脂环烃基团，C 6-14 芳基团，等等]， 其盐或上述化合物的水合物。
• Novel 16,17-acetalsubstituted pregnane-21-oic acid derivatives, process for the preparation thereof and pharmaceutical preparation containing them
  申请人：Aktiebolaget Draco

  公开号：EP0232690A1

  公开（公告）日：1987-08-19

  The invention refers to compounds having activity against inflammatory, allergic, and dermatological conditions. The compounds are characterized by the formula or a stereoisomeric component thereof, in which formula R1 is selected from a straight or branched hydrocarbon chain having 1-4 carbon atoms. The invention also refers to processes for the preparation of these compounds, pharmaceutical preparations containing one of the compounds and a method for the treatment of inflammatory, allergic, muscoskeletal and dermatological conditions.

  本发明指的是具有抗炎、抗过敏和抗皮肤病活性的化合物。这些化合物的特征在于 或其立体异构体成分，其中式 R1 选自具有 1-4 个碳原子的直链或支链烃链。 本发明还涉及这些化合物的制备工艺、含有其中一种化合物的药物制剂以及治疗炎症、过敏、肌肉骨骼和皮肤病的方法。
• SOLUTION COMPOSITIONS OF BLOCK COPOLYIMIDES COMPRISING PYROMELLITIC DIANHYDRIDE AND PROCESS FOR PRODUCTION THEREOF
  申请人：PI R & D Co., Ltd.

  公开号：EP1561786A1

  公开（公告）日：2005-08-10

  Polyimides consisting of PMDA and an aromatic diamine are normally solvent-insoluble. According to the present invention, they are solubilized in solvents to prepare four-component or higher block copolymers containing BTDA. PMDA is reacted with a certain type of aromatic diamine in a molar ratio of 1:2-1.5 to produce a solvent-soluble oligomer. This is combined with an acid dianhydride and an aromatic diamine to produce a four-component or higher solvent-soluble block copolymer. The molar ratio of the aromatic diamine added with PMDA is 1:2-1.5. A number of solvent-soluble block copolymers containing PMDA can be prepared. Four-component or higher polyimide block copolymers containing PMDA, BTDA, and DAT are prepared by sequential reactions in the presence of a binary catalyst. This made it possible to prepare various polyimides from many inexpensively available materials. Polyimides containing PMDA-BTDA-DAT can be prepared at high performance, in mass and at low cost by using economical direct imidation, and therefore can be widely used in future.

  由 PMDA 和芳香族二胺组成的聚酰亚胺通常不溶于溶剂。根据本发明，可将它们溶解在溶剂中，制备含有 BTDA 的四组份或更高组份嵌段共聚物。PMDA 与某种芳香族二胺以 1:2-1.5 的摩尔比进行反应，生成可溶于溶剂的低聚物。低聚物与酸性二酐和芳香族二胺反应生成四组份或更高组份的可溶于溶剂的嵌段共聚物。 芳香族二胺与 PMDA 的摩尔比为 1:2-1.5。可以制备多种含有 PMDA 的溶剂可溶嵌段共聚物。 在二元催化剂存在下，通过连续反应可制备出含有 PMDA、BTDA 和 DAT 的四组份或更高组份的聚酰亚胺嵌段共聚物。这使得利用许多廉价材料制备各种聚酰亚胺成为可能。含有 PMDA-BTDA-DAT 的聚酰亚胺可通过经济的直接酰亚胺法制备出高性能、大规模和低成本的聚酰亚胺，因此可在未来得到广泛应用。
• N-substituted pseudo-aminosugars, their production and use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0089812B1

  公开（公告）日：1986-10-01
• Hydroxypyridinone
  申请人：Novartis AG

  公开号：EP0768302B1

  公开（公告）日：2005-07-06