4-(N-benzylidene-N-phenyl-hydrazino)-butan-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(N-benzylidene-N-phenyl-hydrazino)-butan-2-one
• 英文别名: 4-(N-(benzylideneamino)anilino)butan-2-one
• 化学式: C₁₇H₁₈N₂O
• 分子量: 266.343
• InChiKey: ZJDHTUHVKPINFB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.51
• 重原子数：
  20.0
• 可旋转键数：
  6.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  32.67
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  4-(N-benzylidene-N-phenyl-hydrazino)-butan-2-one 在 盐酸 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以31%的产率得到3-甲基-1-苯基-4,5-二氢吡唑
  参考文献：
  名称：

  DABCO-catalyzed reactions of hydrazones with activated olefins

  摘要：

  This paper describes several highly efficient DABCO-catalyzed aza-Michael addition reactions of hydrazones to activated olefins. In most cases, these aza-Michael addition reactions gave the corresponding products in high yields under mild conditions. The plausible reaction mechanism is discussed on the basis of deuterium labeling experiments. Upon treatment with HCl, the corresponding cyclized products can be obtained in high yields from the Michael addition products. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.04.071
• 作为产物：
  描述：

  丁烯酮 、 苯甲醛苯腙 在 三乙烯二胺 作用下， 以 甲苯 为溶剂， 反应 24.0h， 生成 4-(N-benzylidene-N-phenyl-hydrazino)-butan-2-one
  参考文献：
  名称：

  DABCO-catalyzed reactions of hydrazones with activated olefins

  摘要：

  This paper describes several highly efficient DABCO-catalyzed aza-Michael addition reactions of hydrazones to activated olefins. In most cases, these aza-Michael addition reactions gave the corresponding products in high yields under mild conditions. The plausible reaction mechanism is discussed on the basis of deuterium labeling experiments. Upon treatment with HCl, the corresponding cyclized products can be obtained in high yields from the Michael addition products. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.04.071

文献信息

• DABCO-catalyzed reactions of hydrazones with activated olefins
  作者：Gui-Ling Zhao、Min Shi

  DOI：10.1016/j.tet.2005.04.071

  日期：2005.7

  This paper describes several highly efficient DABCO-catalyzed aza-Michael addition reactions of hydrazones to activated olefins. In most cases, these aza-Michael addition reactions gave the corresponding products in high yields under mild conditions. The plausible reaction mechanism is discussed on the basis of deuterium labeling experiments. Upon treatment with HCl, the corresponding cyclized products can be obtained in high yields from the Michael addition products. (c) 2005 Elsevier Ltd. All rights reserved.