卡巴拉汀EP杂质E | 923035-05-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 卡巴拉汀EP杂质E
• 英文名称: (S)-3-[1-(methylamino)ethyl]-phenyl N-ethyl-N-methyl-carbamate
• 英文别名: N-methylethylcarbamic acid 3-[(S)-1-(methylamino)ethyl]phenyl ester；L-(S)-N-ethyl-3-[1-(methylamino)ethyl]-N-methylphenylcarbamate；3-(1-(Methylamino)ethyl)phenyl ethyl(methyl)carbamate, (1S)-；[3-[(1S)-1-(methylamino)ethyl]phenyl] N-ethyl-N-methylcarbamate
• CAS: 923035-05-6
• 化学式: C₁₃H₂₀N₂O₂
• 分子量: 236.314
• InChiKey: DKTHTUMLVSBQTJ-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  41.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  聚合甲醛 、 卡巴拉汀EP杂质E 在 甲酸 、 sodium carbonate 作用下， 以 水 为溶剂， 以79.3%的产率得到利凡斯的明
  参考文献：
  名称：

  PREPARATION METHOD OF RIVASTIGMINE, ITS INTERMEDIATES AND PREPARATION METHOD OF THE INTERMEDIATES

  摘要：

  公开号：

  EP2233465B1
• 作为产物：
  描述：

  3-[(1S)-1-{methyl[(1S)-1-phenylethyl]amino}ethyl]phenyl N-ethyl-N-methylcarbamate 在 palladium 10% on activated carbon 、 氢气 作用下， 以 甲醇 为溶剂， 60.0 ℃ 、1.01 MPa 条件下， 反应 12.0h， 以10.92 g的产率得到卡巴拉汀EP杂质E
  参考文献：
  名称：

  Novel Convenient Synthesis of Rivastigmine

  摘要：

  A novel and convenient synthesis of rivastigmine has been reported. This procedure provides high yield and excellent enantiomeric excess (100% ee) starting from the diastereromerically pure (S)-1-(3-methoxyphenyl)-N-[(S)-1-phenylethyl] ethanamine.

  DOI：

  10.1080/00397910802531948

文献信息

• PREPATATION METHOD OF RIVASTIGMINE, ITS INTERMEDIATES AND PREPARATION METHOD OF THE INTERMEDIATES
  申请人：Zhang Fuli

  公开号：US20100286437A1

  公开（公告）日：2010-11-11

  The present invention provides N-methylethylcarbamino-3-[(S)-1-(methyl-[(S)-1-phenylethyl]amino)ethyl]phenyl ester represented by formula (II) and its preparation method. The present invention also provides (S)-1-(3-methoxyphenyl)-N-methyl-N—[(S)-1-phenylethyl]ethylamine and 3-[(S)-1-(methyl-[(S)-1-phenylethyl]amino)ethyl]phenol as intermediates of the compound represented by formula (II), and the use of the compound represented by formula (II) for preparing rivastigmine used for treating Alzheimer disease.

  本发明提供了公式（II）所表示的N-甲基乙基氨基-3-[(S)-1-(甲基-[(S)-1-苯乙基]氨基)乙基]苯酯及其制备方法。本发明还提供了(S)-1-(3-甲氧基苯基)-N-甲基-N-[(S)-1-苯乙基]乙胺和3-[(S)-1-(甲基-[(S)-1-苯乙基]氨基)乙基]苯酚作为公式（II）所表示的化合物的中间体，并且提供了利用公式（II）所表示的化合物制备用于治疗阿尔茨海默病的利巴韦林的方法。
• METHOD OF OBTAINING PHENYL CARBAMATES
  申请人：Interquim, S.A.

  公开号：EP1939172B1

  公开（公告）日：2012-07-11
• ANAVEX2-73 AND CERTAIN ANTICHOLINESTERASE INHIBITORS COMPOSITION AND METHOD FOR NEUROPROTECTION
  申请人：Anavex Life Sciences Corp.

  公开号：US20170360798A1

  公开（公告）日：2017-12-21

  This invention concerns a dosage form comprising a therapeutically neuroprotective amount of A2-73 and a neuroprotective amount of at least one cooperating acetylcholinesterase inhibitor selected from the group consisting of donepezil, galantamine, rivastigmine, or memantine and method of use.
• ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
  申请人：CODEXIS, INC.

  公开号：US20220315961A1

  公开（公告）日：2022-10-06

  The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
• US8324429B2
  申请人：——

  公开号：US8324429B2

  公开（公告）日：2012-12-04