H-Ala-NH2*CF3CO2H

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Ala-NH2*CF3CO2H
• 英文别名: (2S)-2-aminopropanamide;2,2,2-trifluoroacetic acid
• 化学式: C₂HF₃O₂*C₃H₈N₂O
• 分子量: 202.133
• InChiKey: JTOSELXEWUMKQP-DKWTVANSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.55
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  草酰氯单乙酯 、 H-Ala-NH2*CF3CO2H 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以27%的产率得到
  参考文献：
  名称：

  [EN] COMPOSITION COMPRISING OXALAMIDE GELATORS AND VEGETABLE OIL
  [FR] COMPOSITION COMPRENANT DES AGENTS DE GÉLIFICATION OXALAMIDE ET DE L'HUILE VÉGÉTALE

  摘要：

  本发明涉及具有凝胶特性的组合物，包括化学式（I）的草酸酰胺凝胶剂和植物油。揭示了该组合物在食品、化妆品或制药行业中的用途。

  公开号：

  WO2020125926A1
• 作为产物：
  描述：

  Boc-L-丙氨酰胺 、 三氟乙酸 以 水 为溶剂， 反应 1.0h， 以100%的产率得到H-Ala-NH2*CF3CO2H
  参考文献：
  名称：

  [EN] COMPOSITION COMPRISING OXALAMIDE GELATORS AND VEGETABLE OIL
  [FR] COMPOSITION COMPRENANT DES AGENTS DE GÉLIFICATION OXALAMIDE ET DE L'HUILE VÉGÉTALE

  摘要：

  本发明涉及具有凝胶特性的组合物，包括化学式（I）的草酸酰胺凝胶剂和植物油。揭示了该组合物在食品、化妆品或制药行业中的用途。

  公开号：

  WO2020125926A1

文献信息

• Syntheses of two tyrosine-sulphate containing peptides. Leucosulfakinin (LSK)-II and cholecystokinin (CCK)-12, using the 0--(methylsulphinyl)benzyl serine for the selective sulphation of tyrosine
  作者：Shiroh Futaki、Takashi Taike、Tadashi Akita、Kouki Kitagawa

  DOI：10.1016/s0040-4020(01)81989-x

  日期：1992.1

  A novel approach for the synthesis of tyrosine sulphate [Tyr(SO3H)]-containing peptides was developed. In this approach, trifluoroacetic acid stable O-p-(methylsulphinyl)-benzyl group was used as a key protecting group for serine to achieve the selective sulphation of tyrosine.

  开发了一种新的合成方法，用于合成含有酪氨酸硫酸盐[Tyr（SO 3 H）]的肽。在这种方法中，三氟乙酸稳定的Op-（甲基亚磺酰基）-苄基被用作丝氨酸的关键保护基，以实现酪氨酸的选择性硫酸化。
• Structure-activity relationships of C-terminal tri- and tetrapeptide fragments that inhibit gastrin activity
  作者：Jean Martinez、Jean Pierre Bali、Richard Magous、Janine Laur、Marie Francoise Lignon、Christian Briet、Dino Nisato、Bertrand Castro

  DOI：10.1021/jm00381a002

  日期：1985.3

  A series of tri- and tetrapeptide derivatives, analogues of the gastrin C-terminal region with no phenylalanine residue, were synthesized. These peptides were tested for their ability to inhibit gastrin-stimulated acid secretion in vivo as well as binding of [125I]-(Nle11)-HG-13 to gastric mucosal cell receptors in vitro. Most of the peptides tested exhibited gastrin antagonist activity in vivo and in vitro. Most active derivatives were 20-30 times more potent than the well-known gastrin antagonist derivatives proglumide and benzotript and had 20-200 times more binding affinity. The smallest fragment exhibiting antagonist activity was the tripeptide Boc-L-tryptophyl-L-methionyl-L-aspartic acid amide.
• Synthesis and antitumour evaluation of peptidyl-like derivatives containing the 1,3-benzodioxole system
  作者：Diogo Rodrigo de Magalhães Moreira、Ana Cristina Lima Leite、Paulo Michel Pinheiro Ferreira、Patrícia Marçal da Costa、Letícia Veras Costa Lotufo、Manoel Odorico de Moraes、Dalci José Brondani、Claudia do Ó Pessoa

  DOI：10.1016/j.ejmech.2006.10.007

  日期：2007.3

  In the scope of a research program aiming at the synthesis and pharmacological evaluation of novel possible antitumour prototype compounds, we described in this paper the synthesis of peptidyl-like derivatives containing the 1,3-benzodioxole system. The proliferation inhibitors tested against tumour cell lines identified the derivatives tyrosine (4f) and lysine (4g) as the most active among them, presenting IC50 values in micromolar range and are more active than Safrole. For the study on the embryonic development, Safrole did not show any selectivity in this latter assay, which indicates that Safrole acts as a 'cell cycle-nonspecific' inhibitory agent. However, compound M presented a fair antimitotic effect, mainly on third cleavage and blastulae stages (38% and 1.7% of normal development, at 10 mu g/mL), suggesting a time-dependent activity and a 'cell cycle-specific' agent action. Neither derivatives revealed hemolytic action in assay with mouse erythrocytes. (c) 2006 Elsevier Masson SAS. All rights reserved.
• Structural studies of [2′,6′-dimethyl-l-tyrosine1]endomorphin-2 analogues: enhanced activity and cis orientation of the Dmt-Pro amide bond
  作者：Yoshio Okada、Yoshio Fujita、Takashi Motoyama、Yuko Tsuda、Toshio Yokoi、Tingyou Li、Yusuke Sasaki、Akihiro Ambo、Yunden Jinsmaa、Sharon D. Bryant、Lawrence H. Lazarus

  DOI：10.1016/s0968-0896(03)00068-3

  日期：2003.5

  Analogues of endomorphin-2 (EM-2: Tyr-Pro-Phe-Phe-NH2) (1) were designed to examine the importance of each residue on mu-opioid receptor interaction. Replacement of Tyr(1) by 2',6'-dimethyl-L-tyrosine (Dmt) (9-12) exerted profound effects: [Dmt(1)]EM-2 (9) elevated mu-opioid affinity 4.6-fold (K(i)mu = 0.15 nM) yet selectivity fell 330-fold as delta-affinity rose (K(i)delta = 28.2 nM). This simultaneous increased mu- and delta-receptor bioactivities resulted in dual agonism (IC50 = 0.07 and 1.87 nM, respectively). While substitution of Phe(4) by a phenethyl group (4) decreased mu affinity (K(i)mu 13.3 nM), the same derivative containing Dmt (12) was comparable to EM-2 but also acquired weak delta antagonism (pA(2) = 7.05). H-1 NMR spectroscopy revealed a trans configuration (1:2 to 1:3, cis/trans) in the Tyr-Pro amide bond, but a cis configuration (5:3 to 13:7, cis/trans) with Dmt-Pro analogues. (C) 2003 Elsevier Science Ltd. All rights reserved.
• [EN] COMPOSITION COMPRISING OXALAMIDE GELATORS AND VEGETABLE OIL<br/>[FR] COMPOSITION COMPRENANT DES AGENTS DE GÉLIFICATION OXALAMIDE ET DE L'HUILE VÉGÉTALE
  申请人：RUDJER BOSKOVIC INST

  公开号：WO2020125926A1

  公开（公告）日：2020-06-25

  The present invention relates to the composition with gelling properties comprising oxalamide gelators of Formula (I) and a vegetable oil. Uses of such composition in the food, cosmetic or pharmaceutical industry are disclosed.

  本发明涉及具有凝胶特性的组合物，包括化学式（I）的草酸酰胺凝胶剂和植物油。揭示了该组合物在食品、化妆品或制药行业中的用途。