1-(4-methoxyphenyl)-4,6-diphenylindoline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(4-methoxyphenyl)-4,6-diphenylindoline
• 英文别名: 1-(4-Methoxyphenyl)-4,6-diphenyl-2,3-dihydroindole；1-(4-methoxyphenyl)-4,6-diphenyl-2,3-dihydroindole
• 化学式: C₂₇H₂₃NO
• 分子量: 377.486
• InChiKey: QOUDHMWHKCDQAR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  29
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-methoxy-N-(pent-4-ynyl)aniline 、 反式-查耳酮 在 potassium tetrachloroplatinate(II) 作用下， 以 甲醇 为溶剂， 反应 0.5h， 以75%的产率得到1-(4-methoxyphenyl)-4,6-diphenylindoline
  参考文献：
  名称：

  微波辅助条件下铂催化串联环化反应合成取代的二氢吲哚

  摘要：

  AbstractA convenient platinum‐catalyzed tandem cyclization reaction from readily available aminoalkynes and enones has been developed to efficiently prepare multiply substituted indolines in good yields under microwave irradiation within a short reaction time. This efficient reaction is presumed to proceed via a tandem process involving intramolecular hydroamination of aminoalkynes, Michael addition of enones, aldol condensation and intermolecular transfer hydrogenation.magnified image

  DOI：

  10.1002/adsc.201400933

文献信息

• Platinum-Catalyzed Tandem Cyclization Reaction to Multiply Substituted Indolines under Microwave-Assisted Conditions
  作者：Can-Liang Ma、Xiao-Long Yu、Xiao-Long Zhu、Yong-Zhou Hu、Xiao-Wu Dong、Bin Tan、Xin-Yuan Liu

  DOI：10.1002/adsc.201400933

  日期：2015.2.9

  AbstractA convenient platinum‐catalyzed tandem cyclization reaction from readily available aminoalkynes and enones has been developed to efficiently prepare multiply substituted indolines in good yields under microwave irradiation within a short reaction time. This efficient reaction is presumed to proceed via a tandem process involving intramolecular hydroamination of aminoalkynes, Michael addition of enones, aldol condensation and intermolecular transfer hydrogenation.magnified image