7-(4-Dimethylaminoanilino)-5-methyl-1H-pyrazolo[4,3-b]pyridine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 7-(4-Dimethylaminoanilino)-5-methyl-1H-pyrazolo[4,3-b]pyridine
• 英文别名: 4-N,4-N-dimethyl-1-N-(5-methyl-1H-pyrazolo[4,3-b]pyridin-7-yl)benzene-1,4-diamine
• 化学式: C₁₅H₁₇N₅
• 分子量: 267.333
• InChiKey: KCSHWYMTILDXKN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  56.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  7-氯-5-甲基-1H-吡唑并[4,3-b]-吡啶 、 N,N-二甲基-对苯二胺 以 乙醇 、 水 为溶剂， 以80%的产率得到7-(4-Dimethylaminoanilino)-5-methyl-1H-pyrazolo[4,3-b]pyridine
  参考文献：
  名称：

  Pyrazolopyridine derivatives and their use as anti-inflammatory and/or

  摘要：

  化合物的化学式(I)及其药用盐：其中：R.sub.1是氢、C.sub.1-6烷基或苯基，可以选择性地被卤素、CF.sub.3、C.sub.1-4烷氧基或C.sub.1-4烷基取代；R.sub.2是氢或C.sub.1-6烷基；R.sub.3是羟基、硝基、氰基、C.sub.2-10酰氧基、NR.sub.6 R.sub.7，其中R.sub.6和R.sub.7分别独立地选择自氢、C.sub.1-6烷基、C.sub.2-7烷酰基或C.sub.1-6烷基磺酰基；或COR.sub.8，其中R.sub.8是羟基、C.sub.1-6烷氧基或NR.sub.9 R.sub.10，其中R.sub.9和R.sub.10分别独立地选择自氢或C.sub.1-6烷基；R.sub.4是氢、卤素、CF.sub.3、C.sub.1-4烷氧基、C.sub.1-4烷基或R.sub.3中列出的任何基团；R.sub.5是氢、C.sub.1-4烷基或苄基，苄基可以在苯环上选择性地被卤素、CF.sub.3、C.sub.1-4烷氧基或C.sub.1-4烷基取代，并且连接在氮原子1或2处，具有抗炎和/或抗过敏活性，以及它们作为药物的用途。

  公开号：

  US04576952A1

文献信息

• Pyrazolopyridine derivatives
  申请人：BEECHAM GROUP PLC

  公开号：EP0151962A2

  公开（公告）日：1985-08-21

  Compound of formula (I) and pharmaceutically acceptable salts thereof: wherein: R, is hydrogen, C, alkyl or phenyl optionally substituted by halogen, CF3, C1-4 alkoxy or C1-4 alkyl; R2 is hydrogen or C1-6 alkyl; R3 is hydroxy, nitro, cyano. C2-10 acyloxy, NR6R7 wherein R8 and R7 are independently selected from hydrogen, C1-6 alkyl, C2-7 alkanoyl or C1-6 alkylsulphonyl: or CORe wherein R8 is hydroxy, C1-8 alkoxy or NR9R10 wherein R9 and R10 are independently selected from hydrogen or C1-6 alkyl; R. is hydrogen, halogen, CF3, C1-4 alkoxy, C1-4 alkyl or any of the groups listed for R3; and R5 is hydrogen, C1-4 alkyl or benzyl optionally substituted in the phenyl ring by halogen, CF3, C1-4 alkoxy or C1-4 alkyl and is attached at nitrogen atom 1 or 2, having anti-inflammatory and/or anti-allergy activity, a process for their preparation and their use as pharmaceuticals.

  式(I)化合物及其药学上可接受的盐类： 其中 R，是氢、C、烷基或任选被卤素、CF3、C1-4 烷氧基或 C1-4 烷基取代的苯基； R2 是氢或 C1-6 烷基； R3 是羟基、硝基、氰基。或 CORe，其中 R8 是羟基、C1-8 烷氧基或 NR9R10，其中 R9 和 R10 独立地选自氢或 C1-6 烷基； R. 是氢、卤素、CF3、C1-4 烷氧基、C1-4 烷基或 R3 所列的任何基团；以及 R5是氢、C1-4烷基或在苯基环上任选被卤素、CF3、C1-4烷氧基或C1-4烷基取代并连接在氮原子1或2上的苄基，具有抗炎和/或抗过敏活性，其制备方法及其作为药物的用途。
• US4576952A
  申请人：——

  公开号：US4576952A

  公开（公告）日：1986-03-18
• Pyrazolopyridine derivatives and their use as anti-inflammatory and/or
  申请人：Beecham Group p.l.c.

  公开号：US04576952A1

  公开（公告）日：1986-03-18

  Compounds of formula (I) and pharmaceutically acceptable salts thereof: ##STR1## wherein: R.sub.1 is hydrogen, C.sub.1-6 alkyl or phenyl optionally substituted by halogen, CF.sub.3, C.sub.1-4 alkoxy or C.sub.1-4 alkyl; R.sub.2 is hydrogen or C.sub.1-6 alkyl; R.sub.3 is hydroxy, nitro, cyano, C.sub.2-10 acyloxy, NR.sub.6 R.sub.7 wherein R.sub.6 and R.sub.7 are independently selected from hydrogen, C.sub.1-6 alkyl, C.sub.2-7 alkanoyl or C.sub.1-6 alkylsulphonyl; or COR.sub.8 wherein R.sub.8 is hydroxy, C.sub.1-6 alkoxy or NR.sub.9 R.sub.10 wherein R.sub.9 and R.sub.10 are independently selected from hydrogen or C.sub.1-6 alkyl; R.sub.4 is hydrogen, halogen, CF.sub.3, C.sub.1-4 alkoxy, C.sub.1-4 alkyl or any of the groups listed for R.sub.3 ; and R.sub.5 is hydrogen, C.sub.1-4 alkyl or benzyl optionally substituted in the phenyl ring by halogen, CF.sub.3, C.sub.1-4 alkoxy or C.sub.1-4 alkyl and is attached at nitrogen atom 1 or 2, having anti-inflammatory and/or anti-allergy activity, and their use as pharmaceuticals.

  化合物的化学式(I)及其药用盐：其中：R.sub.1是氢、C.sub.1-6烷基或苯基，可以选择性地被卤素、CF.sub.3、C.sub.1-4烷氧基或C.sub.1-4烷基取代；R.sub.2是氢或C.sub.1-6烷基；R.sub.3是羟基、硝基、氰基、C.sub.2-10酰氧基、NR.sub.6 R.sub.7，其中R.sub.6和R.sub.7分别独立地选择自氢、C.sub.1-6烷基、C.sub.2-7烷酰基或C.sub.1-6烷基磺酰基；或COR.sub.8，其中R.sub.8是羟基、C.sub.1-6烷氧基或NR.sub.9 R.sub.10，其中R.sub.9和R.sub.10分别独立地选择自氢或C.sub.1-6烷基；R.sub.4是氢、卤素、CF.sub.3、C.sub.1-4烷氧基、C.sub.1-4烷基或R.sub.3中列出的任何基团；R.sub.5是氢、C.sub.1-4烷基或苄基，苄基可以在苯环上选择性地被卤素、CF.sub.3、C.sub.1-4烷氧基或C.sub.1-4烷基取代，并且连接在氮原子1或2处，具有抗炎和/或抗过敏活性，以及它们作为药物的用途。