1-(5-(2-methoxyphenyl)thiophen-2-yl)ethanone

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(5-(2-methoxyphenyl)thiophen-2-yl)ethanone
• 英文别名: 1-[5-(2-Methoxyphenyl)-2-thienyl]ethanone；1-[5-(2-methoxyphenyl)thiophen-2-yl]ethanone
• 化学式: C₁₃H₁₂O₂S
• 分子量: 232.303
• InChiKey: QXIHXMDXASHNSE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  54.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-乙酰基-5-溴噻吩 、 2-溴苯甲醚 在 potassium phosphate 作用下， 以 N,N-二甲基乙酰胺 为溶剂， 反应 24.0h， 以61%的产率得到1-(5-(2-methoxyphenyl)thiophen-2-yl)ethanone
  参考文献：
  名称：

  Visible light induced cross-coupling synthesis of asymmetrical heterobiaryls using Pd/CeO2 nanocomposite photocatalyst

  摘要：

  A simple, mild and green approach has been developed for the synthesis of asymmetrical heterobiaryls under the irradiation of visible light without any oxidants and promoting reagents through using Pd/CeO2 nanocomposite photocatalyst. This method can tolerate considerable functional groups such as electron donating groups and electron-withdrawing groups through C-C cross-coupling. Moreover, we obtain the products with moderate yields in an efficient way. Finally, a plausible mechanism is proposed. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.cclet.2018.01.002

文献信息

• Visible light induced cross-coupling synthesis of asymmetrical heterobiaryls using Pd/CeO2 nanocomposite photocatalyst
  作者：Yanqin Ge、Pinhui Diao、Chen Xu、Nannan Zhang、Cheng Guo

  DOI：10.1016/j.cclet.2018.01.002

  日期：2018.6

  A simple, mild and green approach has been developed for the synthesis of asymmetrical heterobiaryls under the irradiation of visible light without any oxidants and promoting reagents through using Pd/CeO2 nanocomposite photocatalyst. This method can tolerate considerable functional groups such as electron donating groups and electron-withdrawing groups through C-C cross-coupling. Moreover, we obtain the products with moderate yields in an efficient way. Finally, a plausible mechanism is proposed. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.