去甲肾上腺色素 | 490-89-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 去甲肾上腺色素
• 中文别名: 去甲肾上腺素杂质21；氨基甲硫酸,二甲基-,S,S-(3,3-二甲基1,1-联苯基-2,2-二基)酯
• 英文名称: noradrenochrome
• 英文别名: 3-hydroxy-2,3-dihydro-indole-5,6-dione；3-hydroxy-indoline-5,6-dione；3,6-Dihydroxy-5-oxo-3,5-dihydro-2H-indolium-betain；3-Hydroxy-indolin-5,6-dion；Noradrenochrom, 3-Hydroxy-2,3-dihydro-indol-chinon-(5,6)；3-Hydroxy-2,3-dihydro-indol-5,6-chinon；3-hydroxy-2,3-dihydro-1H-indole-5,6-dione
• CAS: 490-89-1
• 化学式: C₈H₇NO₃
• 分子量: 165.148
• InChiKey: LXXQZMIOKXLXPT-UHFFFAOYSA-N

物化性质

• 沸点：
  410.4±45.0 °C(Predicted)
• 密度：
  1.49±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  去甲肾上腺色素 、 DL-去甲肾上腺素 以0%的产率得到
  参考文献：
  名称：

  Salem F. B., Anal. Lett., 26 (1993) N 2, S 281-294

  摘要：

  DOI：
• 作为产物：
  描述：

  去甲肾上腺素 在 甲醇 、 silver(l) oxide 作用下， 生成 去甲肾上腺色素
  参考文献：
  名称：

  Chemistry of the Aminochromes. Part XIV. Noradrenochrome

  摘要：

  将去甲肾上腺素及其单半硫脲酮的纯结晶形式制备以及它们的一些重要性质描述。

  DOI：

  10.1139/v71-055

文献信息

• Kruk, I., Zeitschrift fur Physikalische Chemie (Leipzig), 1987, vol. 268, # 3, p. 607 - 613
  作者：Kruk, I.

  DOI：——

  日期：——
• Disproportionation During Electrooxidation of Catecholamines at Carbon-Fiber Microelectrodes
  作者：Edward L. Ciolkowski、Karolyn M. Maness、Paula S. Cahill、R. Mark. Wightman、Dennis H. Evans、Bruno. Fosset、Christian. Amatore

  DOI：10.1021/ac00093a013

  日期：1994.11.1

  The effect of following chemical reactions during chronoamperometry and cyclic voltammetry at microelectrodes has been evaluated by digital simulation and the results have been compared to experiments. This study was motivated by the demonstrated utility of microelectrodes to monitor catecholamine secretion from individual biological cells. Since following chemical reactions can increase the total number of coulombs passed, such an occurrence can affect the calibration of the measured response. However, at microelectrodes, products formed by chemical reactions after electron transfer are less likely to return to the electrode because of the divergent diffusion field that can exist at electrodes of small dimensions. The degree to which these effects are apparent has been evaluated quantitatively by digital simulation of the DISP1 scheme for a disk-shaped electrode. The predictions of the simulation are verified in an experimental study of the anodic oxidation of diphenylanthracene in acetonitrile containing pyridine. In contrast, the DISP1 reaction of catecholamines at carbon-fiber microelectrodes exhibits much less enhanced current than predicted by theory. The experimental data suggest this is due to the heterogenous nature of the carbon surface with respect to electron transfer. Thus, for most applications of carbon-fiber microelectrodes as sensors of catecholamine secretion from cells, the effect of the DISP1 reaction can be ignored.
• Caractères comparés de l'oxydation de la noradrénaline et de l'adrénaline évoluant en solution tampon phosphate ou bicarbonate
  作者：Paulette Chaix、Claude Pallaget

  DOI：10.1016/0006-3002(53)90278-9

  日期：1953.1
• Zur Darstellung von Nor-Adrenochrom
  作者：Peter Marquardt、Elisabeth Carl

  DOI：10.1007/bf00596873

  日期：——
• UV-OVERPROTECTING IRIDESCENT COLORED CONTACT LENSES
  申请人：The University of Akron

  公开号：US20210373358A1

  公开（公告）日：2021-12-02

  In various embodiments, the present invention is directed to contact lenses that utilize a multilayer coating of alternating high RI materials, such as melanin or polydopamine (PDA) and other low RI materials to create tunable iridescent colors and contain melanin or similar materials that impart photoprotection due to their broadband UV-vis absorption spectrum and ability to quench radicals.