2-Hydroxy-2-trimethylsilylpropanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 2-Hydroxy-2-trimethylsilylpropanoic acid
• 英文别名: 2-hydroxy-2-trimethylsilypropanoic acid；Tms-lactic acid
• 化学式: C₆H₁₄O₃Si
• 分子量: 162.261
• InChiKey: UEGVGLHJWNWIJI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(三甲基硅基)丙炔 、 二甲基二环氧乙烷 以93%的产率得到2-Hydroxy-2-trimethylsilylpropanoic acid
  参考文献：
  名称：

  Chiral α-Hydroxy Acids: Racemic 2-Hydroxy-2,3,3-trimethylbutanoic Acid and 2-Hydroxy-2-trimethylsilylpropanoic Acid

  摘要：

  Both C7H14O3 and C6H14O3Si crystallize as racemates from acetone solution, the former incorporating water of crystallization (C7H14O3.0.5H(2)O). The crystal structures display extensive intermolecular hydrogen bonding involving the hydroxy and carboxylic acid groups to give polymeric networks.

  DOI：

  10.1107/s0108270195015769

文献信息

• Chemistry of dioxiranes. 22. Reaction of dimethyldioxirane with alkynes
  作者：Robert W. Murray、Megh Singh

  DOI：10.1021/jo00071a016

  日期：1993.9

  The reaction of dimethyldioxirane with several alkynes gives products which are conveniently rationalized by postulating the intermediacy of oxirenes and oxocarbenes. The latter serve as precursors to H atom or methyl group migration products, as well as to cyclopropane insertion products in some cases. Alkenes, derived from some of these carbene reactions, are partially converted to epoxides.
• Chiral α-Hydroxy Acids: Racemic 2-Hydroxy-2,3,3-trimethylbutanoic Acid and 2-Hydroxy-2-trimethylsilylpropanoic Acid
  作者：R. W. Murray、M. Singh、N. P. Rath

  DOI：10.1107/s0108270195015769

  日期：1996.5.15

  Both C7H14O3 and C6H14O3Si crystallize as racemates from acetone solution, the former incorporating water of crystallization (C7H14O3.0.5H(2)O). The crystal structures display extensive intermolecular hydrogen bonding involving the hydroxy and carboxylic acid groups to give polymeric networks.