N-(4-isobutoxyphenyl)-2,4-dimethoxybenzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-isobutoxyphenyl)-2,4-dimethoxybenzamide
• 化学式: C₁₉H₂₃NO₄
• 分子量: 329.396
• InChiKey: WEAIEIRMHNELEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.99
• 重原子数：
  24.0
• 可旋转键数：
  7.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  56.79
• 氢给体数：
  1.0
• 氢受体数：
  4.0

反应信息

• 作为产物：
  描述：

  4-((tetrahydro-2H-pyran-2-yl)oxy)aniline 在 4-二甲氨基吡啶 、 potassium carbonate 、 对甲苯磺酸 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 二甲基亚砜 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.0h， 生成 N-(4-isobutoxyphenyl)-2,4-dimethoxybenzamide
  参考文献：
  名称：

  [EN] ENHANCED OSTEOGENIC ACTIVITY OF DAIDZEIN ANALOGS ON HUMAN MESENCHYMAL STEM CELLS
  [FR] ACTIVITÉ OSTÉOGÉNIQUE ACCRUE D'ANALOGUES DE LA DAIDZÉINE SUR LES CELLULES SOUCHES MÉSENCHYMATEUSES HUMAINES

  摘要：

  公开号：

  WO2014165723A3

文献信息

• Enhanced Osteogenic Activity of Daidzein Analogs on Human Mesenchymal Stem Cells
  申请人：THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

  公开号：US20160068542A1

  公开（公告）日：2016-03-10

  Disclosed are daidzein analogs having the formula (I). Also disclosed are compositions, include a disclosed daidzein analogs, methods of preventing or treating bone disease or bone injury and/or stimulating bone growth, in a subject that include administering to the subject an effective amount of disclosed daidzein analog. Disclosed are isolated mesenchymal stem cell that has been altered by treatment a disclosed daidzein analog, daidzein, glycinol, glyceollin I, or glyceollin II, to increase the osteogenic potential of the mesenchymal stem cells.

  本发明揭示了具有公式（I）的daidzein类似物。还揭示了包括所述daidzein类似物的组合物，用于预防或治疗骨疾病或骨损伤和/或刺激骨生长的方法，包括向受体施用揭示的daidzein类似物的有效量。本发明揭示了已通过处理揭示的daidzein类似物，daidzein，glycinol，glyceollin I或glyceollin II而改变的分离的间充质干细胞，以增加间充质干细胞的成骨潜能。
• [EN] ENHANCED OSTEOGENIC ACTIVITY OF DAIDZEIN ANALOGS ON HUMAN MESENCHYMAL STEM CELLS<br/>[FR] ACTIVITÉ OSTÉOGÉNIQUE ACCRUE D'ANALOGUES DE LA DAIDZÉINE SUR LES CELLULES SOUCHES MÉSENCHYMATEUSES HUMAINES
  申请人：UNIV TULANE

  公开号：WO2014165723A3

  公开（公告）日：2014-12-31
• ENHANCED OSTEOGENIC ACTIVITY OF DAIDZEIN ANALOGS ON HUMAN MESENCHYMAL STEM CELLS
  申请人：The Administrators of the Tulane Educational Fund

  公开号：EP2981530A2

  公开（公告）日：2016-02-10
• Design, Synthesis, and Osteogenic Activity of Daidzein Analogs on Human Mesenchymal Stem Cells
  作者：Amy L. Strong、Quan Jiang、Qiang Zhang、Shilong Zheng、Stephen M. Boue、Steven Elliott、Matthew E. Burow、Bruce A. Bunnell、Guangdi Wang

  DOI：10.1021/ml400397k

  日期：2014.2.13

  Osteoporosis is caused by an overstimulation of osteoclast activity and the destruction of the bone extracellular matrix. Without the normal architecture, osteoblast cells are unable to rebuild phenotypically normal bone. Hormone replacement therapy with estrogen has been effective in increasing osteoblast activity but also has resulted in the increased incidence of breast and uterine cancer. In this study we designed and synthesized a series of daidzein analogs to investigate their osteogenic induction potentials. Human bone marrow derived mesenchymal stem cells (MSCs) from three different donors were treated with daidzein analogs and demonstrated enhanced osteogenesis when compared to daidzein treatment. The enhanced osteogenic potential of these daidzein analogs resulted in increased osterix (Sp7), alkaline phosphatase (ALP), osteopontin (OPN), and insulin-like growth factor 1 (IGF-1), which are osteogenic transcription factors that regulate the maturation of osteogenic progenitor cells into mature osteoblast cells.