3-N-Benzylcarbamoyl-3-methylpropionsaeure

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-N-Benzylcarbamoyl-3-methylpropionsaeure
• 英文别名: 4-(Benzylamino)-3-methyl-4-oxobutanoic acid
• 化学式: C₁₂H₁₅NO₃
• 分子量: 221.256
• InChiKey: LDPUANYLZCXDCM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-N-Benzylcarbamoyl-3-methylpropionsaeure 在 乙酰氯 作用下， 生成 N-benzyl-α-methylsuccinimide
  参考文献：
  名称：

  Syntheses, in vitro antibacterial and cytotoxic activities of a series of 3-substituted succinimides

  摘要：

  We have synthesized a series of 3-substituted succinimides and their in vitro antibacterial activities have been tested towards Gram-positive and Gram-negative bacteria from the ATCC collection. Some of them possess significant antibacterial activity against Gram-positive organisms (Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212) but all are poorly active or inactive against Gram-negative organisms (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853). The compounds with the lowest minimal inhibitory concentrations (esters of 3-hydroxy succinimides) are also the most cytotoxic against green monkey Vero cell line (ATCC CCL-81) and could explain that perhaps apoptosis should be implicated in eukaryotic cell cytotoxicity of succinimides.

  DOI：

  10.1016/j.farmac.2004.07.007
• 作为产物：
  描述：

  甲基丁二酸 在 乙酰氯 作用下， 生成 3-N-Benzylcarbamoyl-3-methylpropionsaeure
  参考文献：
  名称：

  Syntheses, in vitro antibacterial and cytotoxic activities of a series of 3-substituted succinimides

  摘要：

  We have synthesized a series of 3-substituted succinimides and their in vitro antibacterial activities have been tested towards Gram-positive and Gram-negative bacteria from the ATCC collection. Some of them possess significant antibacterial activity against Gram-positive organisms (Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212) but all are poorly active or inactive against Gram-negative organisms (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853). The compounds with the lowest minimal inhibitory concentrations (esters of 3-hydroxy succinimides) are also the most cytotoxic against green monkey Vero cell line (ATCC CCL-81) and could explain that perhaps apoptosis should be implicated in eukaryotic cell cytotoxicity of succinimides.

  DOI：

  10.1016/j.farmac.2004.07.007

文献信息

• Syntheses, in vitro antibacterial and cytotoxic activities of a series of 3-substituted succinimides
  作者：Frédéric Zentz、Régis Le Guillou、Roger Labia、Danielle Sirot、Boris Linard、Alain Valla

  DOI：10.1016/j.farmac.2004.07.007

  日期：2004.11

  We have synthesized a series of 3-substituted succinimides and their in vitro antibacterial activities have been tested towards Gram-positive and Gram-negative bacteria from the ATCC collection. Some of them possess significant antibacterial activity against Gram-positive organisms (Staphylococcus aureus ATCC 25923 and Enterococcus faecalis ATCC 29212) but all are poorly active or inactive against Gram-negative organisms (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853). The compounds with the lowest minimal inhibitory concentrations (esters of 3-hydroxy succinimides) are also the most cytotoxic against green monkey Vero cell line (ATCC CCL-81) and could explain that perhaps apoptosis should be implicated in eukaryotic cell cytotoxicity of succinimides.