p-nitrobenzyl cyclohexyl ether

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: p-nitrobenzyl cyclohexyl ether
• 英文别名: 1-(Cyclohexyloxymethyl)-4-nitrobenzene
• 化学式: C₁₃H₁₇NO₃
• 分子量: 235.283
• InChiKey: SNWJHHPWEONCOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  p-nitrobenzyl cyclohexyl ether 在 氢气 作用下， 以 甲醇 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 1.83h， 以98%的产率得到cyclohexyl 4-aminobenzyl ether
  参考文献：
  名称：

  Chemoselective hydrogenation of nitrobenzyl ethers to aminobenzyl ethers catalyzed by palladium–nickel bimetallic nanoparticles

  摘要：

  A highly efficient and chemoselective hydrogenation of nitrobenzyl ethers to aminobenzyl ethers was developed by using a novel palladium nickel bimetallic nanocatalyst. Since the catalytic selectivity was resulted from the synergistic effects between two metals rather than the traditional catalyst poisons, the hydrogenation proceeded smoothly under additive-free conditions. Thus, the work-up procedure was as simple as to recover the catalyst by a magnetic separation and then to evaporate the solvent. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2015.10.037
• 作为产物：
  描述：

  对硝基溴化苄 、 环己醇 在 iron(II) sulfate 作用下， 反应 12.0h， 以98%的产率得到p-nitrobenzyl cyclohexyl ether
  参考文献：
  名称：

  FeSO4介导的苄基烷基醚合成新方法

  摘要：

  摘要 已经描述了在温和条件下不使用碱和助溶剂，使用 FeSO4 作为可回收和可重复使用的介质，从苄基溴和醇合成苄基烷基醚。

  DOI：

  10.1080/00397911003642674

文献信息

• Direct Oxidation of Methyl Ethers to Carbonyl Compounds with a Combination of Nitrogen Dioxide and Water in the Presence or Absence of Ozone
  作者：Hitomi Suzuki、Toyomi Takeuchi、Tadashi Mori

  DOI：10.1246/bcsj.70.3111

  日期：1997.12

  expected oxidation product 2 in moderate to good yield. In the presence of ozone, but without water, the similar oxidation was observed only after prolonged reaction time, suggesting that some initial minor reaction with a strong oxidant, possible nitrogen trioxide, afforded an acidic promoter, which then worked as a catalyst similar to that involved in the reaction with a nitrogen dioxide and water

  已发现二氧化氮和水的组合提供了一种新试剂，用于在温和条件下将各种烷基甲基醚 1 (R = Me) 转化为羰基化合物 2。在二氯甲烷中可以成功地实现氧化，但发现六氟-2-丙醇作为溶剂是最令人满意的。反应通常是干净的，简单的蒸发以中等至良好的产率得到预期的氧化产物2。在有臭氧但没有水的情况下，只有在延长反应时间后才能观察到类似的氧化，这表明与强氧化剂（可能是三氧化氮）的一些初始小反应提供了酸性促进剂，然后作为催化剂起作用参与与二氧化氮和水系统的反应。
• Method for the treatment or prevention of bone disorders with a cyclooxygenase-2 inhibitor alone and in combination with a bone disorder treatment agent and compositions therewith
  申请人：Olson Maria Lisa

  公开号：US20050107350A1

  公开（公告）日：2005-05-19

  The present invention describes a novel method for preventing or treating bone disorders and bone disorder-related complications in a subject involving a monotherapy with a Cox-2 inhibitor or a combination therapy with a Cox-2 inhibitor and a bone disorder treatment agent. Also described are therapeutic compositions comprising a Cox-2 inhibitor and a bone disorder treatment agent. Pharmaceutical compositions and kits for implementing the present method are also described.

  本发明描述了一种新的方法，用于预防或治疗受体中的骨骼疾病和与骨骼疾病相关的并发症，包括单独使用Cox-2抑制剂或与骨骼疾病治疗剂的联合治疗。还描述了含有Cox-2抑制剂和骨骼疾病治疗剂的治疗组合物。还描述了用于实施本方法的药物组合物和工具包。
• Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent
  申请人：Wax B. Martin

  公开号：US20050119262A1

  公开（公告）日：2005-06-02

  The present invention provides methods and compositions for the prevention and/or treatment of an optic neuropathy, comprising a Cox-2 inhibitor and an intraocular pressure reducing agent.

  本发明提供了一种预防和/或治疗视神经病变的方法和组合物，包括Cox-2抑制剂和降低眼内压的药物。
• Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
  申请人：Taylor P. Duncan

  公开号：US20050187278A1

  公开（公告）日：2005-08-25

  A method is described for the prevention and/or treatment of vascular disorders and vascular disorder-related complications in a subject, the method comprising administering to the subject a Cox-2 inhibitor in combination with a cAMP-specific PDE inhibitor. Also described are therapeutic and pharmaceutical compositions and kits that are useful in the present invention.

  本文描述了一种用于预防和/或治疗受体内的血管紊乱和血管紊乱相关并发症的方法，该方法包括向受体内注射Cox-2抑制剂和cAMP特异性PDE抑制剂的组合物。同时还描述了在本发明中有用的治疗和药物组合物以及工具包。
• Method for the prevention or treatment of pain, inflammation and inflammation-related disorders with a Cox-2 selective inhibitor in combination with a nitric oxide-donating agent and compositions therewith
  申请人：Connor R. Jane

  公开号：US20050113409A1

  公开（公告）日：2005-05-26

  A method is described for the prevention or treatment of pain, inflammation, and inflammation-related disorders in a subject in need of such prevention or treatment, the method comprising administering to the subject a cyclooxygenase-2 selective inhibitor in combination with a nitric oxide-donating agent. Also described are therapeutic and pharmaceutical compositions and kits that are useful in the present invention.