双(4-硝基苯基)硫酸盐 | 27991-93-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫酸及其衍生物
• 中文名称: 双(4-硝基苯基)硫酸盐
• 英文名称: sulfuric acid bis-(4-nitro-phenyl ester)
• 英文别名: Schwefelsaeure-bis-(4-nitro-phenylester)；Bis-(4-nitro-phenyl)-sulfat；Bis(4-nitrophenyl) sulfate
• CAS: 27991-93-1
• 化学式: C₁₂H₈N₂O₈S
• 分子量: 340.27
• InChiKey: GVQFAOPYVTURQA-UHFFFAOYSA-N

物化性质

• 沸点：
  547.6±50.0 °C(Predicted)
• 密度：
  1.620±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  153
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  双(4-硝基苯基)硫酸盐 在 乙醇 、 镍 作用下， 生成 4,4'-sulfonyldioxy-bis-benzenediazonium; bis tetrafluoroborate
  参考文献：
  名称：

  Bollinger, Bulletin de la Societe Chimique de France, 1948, p. 156

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(4-nitrophenoxy)butanoic acid 在 吡啶 、 磺酰氯 、 甲苯 作用下， 生成 双(4-硝基苯基)硫酸盐
  参考文献：
  名称：

  Bollinger, Bulletin de la Societe Chimique de France, 1948, p. 156

  摘要：

  DOI：
• 作为试剂：
  描述：

  penta-N-acetylchitopentaose 在 aryl sulfotransferase Rhizobium meliloti Nod factor sulfotransferase 、 双(4-硝基苯基)硫酸盐 、 6-氨基-9-[3-羟基-5-[(羟基-磺基氧基-磷酰)氧基甲基]-4-膦酰氧基-四氢呋喃-2-基]-嘌呤 作用下， 以 水 为溶剂， 反应 0.17h， 生成
  参考文献：
  名称：

  Enzymatic Regeneration of 3′-Phosphoadenosine-5′-Phosphosulfate Using Aryl Sulfotransferase for the Preparative Enzymatic Synthesis of Sulfated Carbohydrates

  摘要：

  A cost-efficient preparative enzymatic sulfation of oligosaccharides has been developed. Starting from adenosine 3'5'-diphosphate (PAP), the sulfate donating and highly expensive cofactor 3'-phosphoadenosine-5'-phosphosulfate (PAPS, 1) can be regenerated by using a recombinant aryl sulfotransferase and p-nitrophenyl sulfate. This system averts product inhibition by PAP and can serve as a continuous spectrophotometric assay for the activity of any sulfotransferase enzyme.

  DOI：

  10.1002/(sici)1521-3773(19990917)38:18<2747::aid-anie2747>3.0.co;2-2

文献信息

• MICRO/NANO MATERIALS, PRODUCTS OBTAINED BY COVALENTLY MODIFYING SURFACE OF MICRO/NANO MATERIALS WITH HYDROPHILIC MATERIALS, AND METHOD FOR MAKING SAME
  申请人：CHONGQING BOLANYING (BLY) BIOTECHNOLOGY CO., LTD.

  公开号：US20190077746A1

  公开（公告）日：2019-03-14

  Micro-nano materials, products obtained by covalently modifying the surfaces of micro/nano materials with hydrophilic materials, and methods for making the same. The micro/nano materials on the surfaces have carboxyl groups or/and pro-carboxyl groups which are converted into their active esters. The products are covalently modified by forming amide bonds between the active esters on the surfaces and the modification agents; where the modification agents are hydrophilic compounds and/or hydrophilic polymers bearing primary and/or secondary aliphatic amines. Monomers bearing carboxyl groups and/or pro-carboxyl groups are used to produce an adequate number of carboxyl groups and/or pro-carboxyl groups on the surface of a polymer material to be modified. The carboxyl groups and/or pro-carboxyl groups are converted into active esters. A reasonably-sized modification agent bearing primary and/or secondary amines, zwitterions and hydrophilic linear spacer arms is used to form amide bonds and obtain a covalently modified surface layer.

  微纳米材料，通过用亲水材料共价修饰微/纳米材料表面获得的产品，以及制备这些产品的方法。表面上的微/纳米材料具有羧基或/和前羧基，这些羧基或前羧基被转化为它们的活性酯。通过在表面上的活性酯和修饰剂之间形成酰胺键，共价修饰的产品；其中修饰剂是带有一次和/或二次脂肪胺基的亲水化合物和/或亲水性聚合物。使用带有羧基和/或前羧基的单体来产生足够数量的羧基和/或前羧基，以便在待修饰的聚合物材料表面上形成。将羧基和/或前羧基转化为活性酯。使用合理大小的带有一次和/或二次胺基、带有带电离子和亲水性线性间隔臂的修饰剂来形成酰胺键，并获得共价修饰的表面层。
• [EN] BIOLOGICAL PROCESSES FOR THE PRODUCTION OF ARYL SULFATES<br/>[FR] PROCÉDÉS BIOLOGIQUES DE PRODUCTION DE SULFATES D'ARYLE
  申请人：UNIV DANMARKS TEKNISKE

  公开号：WO2016026976A1

  公开（公告）日：2016-02-25

  The present invention generally relates to the field of biotechnology as it applies to the production of aryl sulfates using polypeptides or recombinant cells comprising said polypeptides. More particularly, the present invention pertains to polypeptides having aryl sulfotransferase activity, recombinant host cells expressing same and processes for the production of aryl sulfates employing these polypeptides or recombinant host cells.

  本发明通常涉及生物技术领域，因其应用于使用多肽或包含该多肽的重组细胞生产芳基硫酸盐。更具体地，本发明涉及具有芳基硫酸转移酶活性的多肽，表达同样多肽的重组宿主细胞以及利用这些多肽或重组宿主细胞生产芳基硫酸盐的过程。
• Arylsulfatase
  申请人：Bristol-Myers Squibb Company

  公开号：EP0423818A1

  公开（公告）日：1991-04-24

  The present invention relates to an arylsulfatase of microbial origin. The enzyme may be linked to an antibody against a tumor-associated antigen and the resulting conjugate used in conjuction with a sulfated prodrug of a 4′-demethylepipodophyllotoxin glucoside derivative, particularly etoposide in cancer chemotherapy.

  本发明涉及一种源于微生物的芳基硫酸酯酶。该酶可与抗肿瘤相关抗原的抗体连接，由此产生的共轭物可与 4′-去甲鬼臼毒素葡萄糖苷衍生物的硫酸化原药，特别是依托泊苷，一起用于癌症化疗。
• METHOD FOR SEARCHING STEROID SULFATASE INHIBITORS
  申请人：KYOWA HAKKO KOGYO CO., LTD.

  公开号：EP1065281A1

  公开（公告）日：2001-01-03

  The present invention provides a method of efficiently screening for steroid sulfatase activity-inhibiting compounds which are useful for the treatment of hormone-dependent diseases such as breast cancer, etc. by causing a test compound to act on cells carrying an introduced steroid sulfatase gene and estimating the inhibiting activity of the compound on the growth of the cells.

  本发明提供了一种有效筛选类固醇硫酸酯酶活性抑制化合物的方法，通过使试验化合物作用于携带引入的类固醇硫酸酯酶基因的细胞，并估计化合物对细胞生长的抑制活性，从而筛选出有助于治疗激素依赖性疾病（如乳腺癌等）的类固醇硫酸酯酶活性抑制化合物。
• METHOD FOR ASSAYING ARYLSULFATASE ACTIVITY
  申请人：Godo Shusei Co., Ltd.

  公开号：EP2687598A1

  公开（公告）日：2014-01-22

  Provided is a method for assaying arylsulfatase activity in aqueous system, which comprises a step for reacting, in an aqueous reaction system with a high ionic strength, arylsulfatase with a substrate thereof, said substrate releasing a fluorophore or a chromophore when subjected to the action of arylsulfatase. Also provided are: a lactase preparation having a lactase activity of 4,000 NLU/g or greater, said lactase activity being assayed by the FCC IV method, and an arylsulfatase activity not greater than 0.1%, said arylsulfatase activity being assayed by the fluorescence method according to the present invention for assaying arylsulfatase activity in aqueous system on the basis of the lactase activity; a method for producing said preparation; and a dairy product with the use of said preparation.

  本发明提供了一种在水性体系中测定芳基硫酸酯酶活性的方法，该方法包括在高离子强度的水性反应体系中使芳基硫酸酯酶与底物反应的步骤，所述底物在受到芳基硫酸酯酶作用时释放出荧光团或发色团。还提供了：一种乳糖酶制剂，其乳糖酶活性为 4,000 NLU/g 或更高，所述乳糖酶活性通过 FCC IV 法进行测定；以及一种芳基硫酸酯酶活性不高于 0.1%的制剂，所述芳基硫酸酯酶活性通过本发明的荧光法进行测定，所述荧光法以乳糖酶活性为基础测定水体系中的芳基硫酸酯酶活性；一种生产所述制剂的方法；以及一种使用所述制剂的乳制品。