3-Hydroxypimeloyl-CoA

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-Hydroxypimeloyl-CoA
• 英文别名: 7-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-5-hydroxy-7-oxoheptanoic acid
• 化学式: C₂₈H₄₆N₇O₂₀P₃S
• 分子量: 925.7
• InChiKey: VGEBXBQECGWCRH-JXUSAFQPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.1
• 重原子数：
  59
• 可旋转键数：
  26
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  447
• 氢给体数：
  11
• 氢受体数：
  25

反应信息

• 作为反应物：
  描述：

  庚二酰-辅酶A 、 3-Hydroxypimeloyl-CoA 、 S-乙酰乙酰基辅酶a 以to form a cyclic product, 6-oxocylohex-1-ene-1-carboxyl-CoA (6-KCH-CoA)的产率得到6-oxocyclohex-1-ene-1-carboxyl-CoA
  参考文献：
  名称：

  ORGANISMS FOR THE PRODUCTION OF CYCLOHEXANONE

  摘要：

  一种非自然发生的微生物体具有环己酮途径，其中包括至少一个外源核酸编码的环己酮途径酶。途径包括一个作用于C-C键的2-酮基环己烷-1-羧酰-辅酶A水解酶，一个2-酮基环己烷-1-羧酸脱羧酶和从2-酮基环己烷-1-羧酰-辅酶A水解酶（作用于硫酯）、2-酮基环己烷-1-羧酰-辅酶A转移酶和2-酮基环己烷-1-羧酰-辅酶A合成酶中选择的酶。途径包括从6-酮基环己-1-烯-1-羧酰-辅酶A水解酶（作用于C-C键）、6-酮基环己-1-烯-1-羧酰-辅酶A合成酶、6-酮基环己-1-烯-1-羧酰-辅酶A水解酶（作用于硫酯）、6-酮基环己-1-烯-1-羧酰-辅酶A转移酶、6-酮基环己-1-烯-1-羧酰-辅酶A还原酶、6-酮基环己-1-烯-1-羧酸脱羧酶、6-酮基环己-1-烯-1-羧酸还原酶、2-酮基环己烷-1-羧酰-辅酶A合成酶、2-酮基环己烷-1-羧酰-辅酶A转移酶、2-酮基环己烷-1-羧酰-辅酶A水解酶（作用于硫酯）、2-酮基环己烷-1-羧酸脱羧酶和环己酮脱氢酶中选择的酶。途径包括己二酸半醛脱水酶、环己-1,2-二醇脱氢酶和环己-1,2-二醇脱水酶。途径包括3-氧代庚二酸脱羧酶、4-乙酰丁酸脱水酶、3-羟基环己酮脱氢酶、2-环己烯酮水合酶、环己酮脱氢酶和从3-氧代庚二酰辅酶A合成酶、3-氧代庚二酰辅酶A水解酶（作用于硫酯）和3-氧代庚二酰辅酶A转移酶中选择的酶。这些途径中的每一个都可以包括PEP羧酸激酶。一种生产环己酮的方法包括培养这些非自然发生的微生物体。

  公开号：

  US20110014668A1

文献信息

• MICROORGANISMS AND METHODS FOR PRODUCTION OF 4-HYDROXYBUTYRATE, 1,4-BUTANEDIOL AND RELATED COMPOUNDS
  申请人：Genomatica, Inc.

  公开号：US20150148513A1

  公开（公告）日：2015-05-28

  The invention provides non-naturally occurring microbial organisms having a 4-hydroxybutyrate, 1,4-butanediol, or other product pathway and being capable of producing 4-hydroxybutyrate, 1,4-butanediol, or other product, wherein the microbial organism comprises one or more genetic modifications. The invention additionally provides methods of producing 4-hydroxybutyrate, 1,4-butanediol, or other product or related products using the microbial organisms.

  该发明提供了具有4-羟基丁酸、1,4-丁二醇或其他产物途径并能够产生4-羟基丁酸、1,4-丁二醇或其他产物的非自然微生物生物体，其中该微生物生物体包括一个或多个基因修饰。该发明还提供了利用这些微生物生物体生产4-羟基丁酸、1,4-丁二醇或其他产物或相关产品的方法。
• ALTERNATIVE PATHWAYS TO ADIPIC ACID BY COMBINED FERMENTATION AND CATALYTIC METHODS
  申请人：BioAmber Inc.

  公开号：US20150225329A1

  公开（公告）日：2015-08-13

  Processes process for producing adipate or adipic acid using biological pathways and chemical catalyzes are disclosed. Homocitric acid may be a substrate in reaction pathways leading to adipic acid or a salt thereof.

  揭示了利用生物途径和化学催化剂生产己二酸盐或己二酸的过程。顺己二酸可能是通向己二酸或其盐的反应途径中的底物。
• Microorganisms for Producing Cyclohexanone and Methods Related Thereto
  申请人：Burgard Anthony

  公开号：US20120329111A1

  公开（公告）日：2012-12-27

  Provided herein is a non-naturally occurring microbial organism having a cyclohexanone pathway and comprising at least one exogenous nucleic acid encoding a cyclohexanone pathway enzyme. Also provided herein is a method for producing cyclohexanone, including culturing these non-naturally occurring microbial organisms.

  本文提供了一种非自然存在的微生物生物体，具有环己酮途径，并且包含至少一个外源核酸编码环己酮途径酶。还提供了一种生产环己酮的方法，包括培养这些非自然存在的微生物生物体。
• ORGANISMS FOR THE PRODUCTION OF CYCLOHEXANONE
  申请人：Genomatica, Inc.

  公开号：US20140356919A1

  公开（公告）日：2014-12-04

  A non-naturally occurring microbial organism has cyclohexanone pathways that include at least one exogenous nucleic acid encoding a cyclohexanone pathway enzyme. A pathway includes a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on C—C bond), a 2-ketocyclohexane-1-carboxylate decarboxylase and an enzyme selected from a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on thioester), a 2-ketocyclohexane-1-carboxyl-CoA transferase, and a 2-ketocyclohexane-1-carboxyl-CoA synthetase. A pathway includes an enzyme selected from a 6-ketocyclohex-1-ene-1-carboxyl-CoA hydrolase (acting on C—C bond), a 6-ketocyclohex-1-ene-1-carboxyl-CoA synthetase, a 6-ketocyclohex-1-ene-1-carboxyl-CoA hydrolase (acting on thioester), a 6-ketocyclohex-1-ene-1-carboxyl-CoA transferase, a 6-ketocyclohex-1-ene-1-carboxyl-CoA reductase, a 6-ketocyclohex-1-ene-1-carboxylate decarboxylase, a 6-ketocyclohex-1-ene-1-carboxylate reductase, a 2-ketocyclohexane-1-carboxyl-CoA synthetase, a 2-ketocyclohexane-1-carboxyl-CoA transferase, a 2-ketocyclohexane-1-carboxyl-CoA hydrolase (acting on thioester), a 2-ketocyclohexane-1-carboxylate decarboxylase, and a cyclohexanone dehydrogenase. A pathway includes an adipate semialdehyde dehydratase, a cyclohexane-1,2-diol dehydrogenase, and a cyclohexane-1,2-diol dehydratase. A pathway includes a 3-oxopimelate decarboxylase, a 4-acetylbutyrate dehydratase, a 3-hydroxycyclohexanone dehydrogenase, a 2-cyclohexenone hydratase, a cyclohexanone dehydrogenase and an enzyme selected from a 3-oxopimeloyl-CoA synthetase, a 3-oxopimeloyl-CoA hydrolase (acting on thioester), and a 3-oxopimeloyl-coA transferase. Each these pathways can include a PEP carboxykinase. A method for producing cyclohexanone includes culturing these non-naturally occurring microbial organisms.

  一种非自然存在的微生物有环己酮途径，其中至少包括一个外源性核酸编码一个环己酮途径酶。途径包括一个2-酮环己烷-1-羧酸-辅酶A水解酶（作用于C-C键），一个2-酮环己烷-1-羧酸脱羧酶和从2-酮环己烷-1-羧酸-辅酶A水解酶（作用于硫酯），2-酮环己烷-1-羧酸-辅酶A转移酶和2-酮环己烷-1-羧酸-辅酶A合成酶中选择的酶。途径包括从6-酮环己-1-烯-1-羧酸-辅酶A水解酶（作用于C-C键），6-酮环己-1-烯-1-羧酸-辅酶A合成酶，6-酮环己-1-烯-1-羧酸-辅酶A水解酶（作用于硫酯），6-酮环己-1-烯-1-羧酸-辅酶A转移酶，6-酮环己-1-烯-1-羧酸-辅酶A还原酶，6-酮环己-1-烯-1-羧酸脱羧酶，6-酮环己-1-烯-1-羧酸还原酶，2-酮环己烷-1-羧酸-辅酶A合成酶，2-酮环己烷-1-羧酸-辅酶A转移酶，2-酮环己烷-1-羧酸-辅酶A水解酶（作用于硫酯），2-酮环己烷-1-羧酸脱羧酶和环己酮脱氢酶中选择的酶。途径包括己二酸半醛脱水酶、环己-1,2-二醇脱氢酶和环己-1,2-二醇脱水酶。途径包括3-氧戊二酸脱羧酶、4-醋酰丁酸脱水酶、3-羟基环己酮脱氢酶、2-环己烯酮水合酶、环己酮脱氢酶和从3-氧戊二酰辅酶A合成酶、3-氧戊二酰辅酶A水解酶（作用于硫酯）和3-氧戊二酰辅酶A转移酶中选择的酶。这些途径中每个都可以包括PEP羧激酶。一种制备环己酮的方法包括培养这些非自然存在的微生物。
• BIOCONVERSION PROCESS FOR PRODUCING NYLON-7, NYLON-7,7 AND POLYESTERS
  申请人：INVISTA TECHNOLOGIES S.a.r.l.

  公开号：US20150337275A1

  公开（公告）日：2015-11-26

  Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.

  本发明实施例涉及在分离酶存在或在表达这些酶的重组宿主细胞存在下，生物合成双或三功能C7烷的方法。这些双或三功能C7烷在生产尼龙-7、尼龙-7，x、尼龙-x，7和聚酯中作为中间体是有用的。