Rhosin

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Rhosin
• 英文别名: (2R)-2-amino-3-(1H-indol-3-yl)-N-[(E)-quinoxalin-6-ylmethylideneamino]propanamide
• 化学式: C₂₀H₁₈N₆O
• 分子量: 358.4
• InChiKey: FGYHLIHEFHCMPP-FVWOBLMASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  109
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Platelet storage methods and compositions for same
  申请人：Children's Hospital Medical Center

  公开号：US10028503B2

  公开（公告）日：2018-07-24

  Disclosed are compositions and methods for slowing, preventing, or reversing platelet damage, particularly as may occur during blood banking or during refrigeration of platelets. The composition may include one or more of a RAC inhibitor, a CDC42 inhibitor, a RHOA inhibitor, or a combination thereof. The compositions may further include a pharmaceutically acceptable carrier.

  所公开的是用于减缓、预防或逆转血小板损伤的组合物和方法，尤其是在血库或冷藏血小板过程中可能发生的损伤。组合物可包括一种或多种 RAC 抑制剂、CDC42 抑制剂、RHOA 抑制剂或其组合。组合物可进一步包括药学上可接受的载体。
• PLATELET STORAGE METHODS AND COMPOSITIONS FOR SAME
  申请人：Children's Hospital Medical Center

  公开号：US20150366182A1

  公开（公告）日：2015-12-24

  Disclosed are compositions and methods for slowing, preventing, or reversing platelet damage, particularly as may occur during blood banking or during refrigeration of platelets. The composition may include one or more of a RAC inhibitor, a CDC42 inhibitor, a RHOA inhibitor, or a combination thereof. The compositions may further include a pharmaceutically acceptable carrier.
• SMALL-MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS
  申请人：CHILDREN'S HOSPITAL MEDICAL CENTER

  公开号：US20160083353A1

  公开（公告）日：2016-03-24

  Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also provided are methods of inhibiting Rho GTPase activation. Also provided are methods of screening for compounds that inhibit Rho GTPase activation by a RhoGEF.
• SMALL- MOLECULE INHIBITORS TARGETING G-PROTEIN-COUPLED RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS
  申请人：Children's Hospital Medical Center

  公开号：US20170349553A1

  公开（公告）日：2017-12-07

  Provided are inhibitors of Rho GTPase activation, and, in particular, compounds that inhibit RhoA activation by an RhoGEF. Also provided are related pharmaceutical compositions and methods. Also provided are methods of inhibiting Rho GTPase activation. Also provided are methods of screening for compounds that inhibit Rho GTPase activation by a RhoGEF.
• US9951024B2
  申请人：——

  公开号：US9951024B2

  公开（公告）日：2018-04-24