4-hydroxy-3-mesityl-1-methoxymethoxy-1-azaspiro[4.5]dec-3-en-2-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-hydroxy-3-mesityl-1-methoxymethoxy-1-azaspiro[4.5]dec-3-en-2-one
• 英文别名: 4-Hydroxy-1-(methoxymethoxy)-3-(2,4,6-trimethylphenyl)-1-azaspiro[4.5]dec-3-en-2-one；4-hydroxy-1-(methoxymethoxy)-3-(2,4,6-trimethylphenyl)-1-azaspiro[4.5]dec-3-en-2-one
• 化学式: C₂₀H₂₇NO₄
• 分子量: 345.439
• InChiKey: VJMJKTWUEVMQCR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  环己甲酸甲酯 在 N,N-二甲基丙烯基脲 、 正丁基锂 、 potassium tert-butylate 、 sodium hydride 、 碳酸氢钠 、 二异丙胺 作用下， 以 四氢呋喃 、 正己烷 、 水 、 乙酸乙酯 、 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 生成 4-hydroxy-3-mesityl-1-methoxymethoxy-1-azaspiro[4.5]dec-3-en-2-one
  参考文献：
  名称：

  Synthesis and insecticidal activity of novel N-oxydihydropyrroles: 4-hydroxy-3-mesityl-1-methoxymethoxy derivatives with various substituents at the 5-position

  摘要：

  This paper reports the synthesis and insecticidal activity of a series of novel 4-hydroxy-3-mesityl-1-methoxymethoxy-1,5-dihydro-2H-pyrrol-2-one derivatives, in which the substituents at the 5-position were varied with a number of alkyl and spirocycloalkyl groups. Investigation of the structure-activity relationships revealed that small alkyl and spirocyclohexyl groups had a favorable effect on the insecticidal activity of these agents against Myzus persicae. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(02)00474-1

文献信息

• Synthesis of N-Oxydihydropyrrole Derivatives
  作者：Mitsuru Ito、Hideshi Okui、Harumi Nakagawa、Shigeru Mio、Toshiaki Iwasaki、Jun Iwabuchi

  DOI：10.3987/com-02-9467

  日期：——

  N-Oxydihydropyrrole derivatives were synthesized through an intramolecular Claisen condensation reaction. The N-acylation of hindered hydroxylamines played a key role in providing the useful intermediates, which could be converted to a variety of N-oxydihydropyrrole derivatives.
• Synthesis and insecticidal activity of novel N-oxydihydropyrroles: 4-hydroxy-3-mesityl-1-methoxymethoxy derivatives with various substituents at the 5-position
  作者：Mitsuru Ito、Hideshi Okui、Harumi Nakagawa、Shigeru Mio、Ayako Kinoshita、Takashi Obayashi、Takako Miura、Junko Nagai、Shinji Yokoi、Reiji Ichinose、Keiji Tanaka、Seiichiro Kodama、Toshiaki Iwasaki、Takaaki Miyake、Miho Takashio、Jun Iwabuchi

  DOI：10.1016/s0968-0896(02)00474-1

  日期：2003.3

  This paper reports the synthesis and insecticidal activity of a series of novel 4-hydroxy-3-mesityl-1-methoxymethoxy-1,5-dihydro-2H-pyrrol-2-one derivatives, in which the substituents at the 5-position were varied with a number of alkyl and spirocycloalkyl groups. Investigation of the structure-activity relationships revealed that small alkyl and spirocyclohexyl groups had a favorable effect on the insecticidal activity of these agents against Myzus persicae. (C) 2002 Elsevier Science Ltd. All rights reserved.