醋酸甲氧基乙基汞 | 151-38-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 醋酸甲氧基乙基汞
• 中文别名: 乙酸甲氧基乙基汞
• 英文名称: 2-methoxy-ethylmercury (1+); acetate
• 英文别名: 2-Methoxy-aethylquecksilber(1+); Acetat；Methoxy-ethyl-quecksilberacetat
• CAS: 151-38-2
• 化学式: C₅H₁₀HgO₃
• 分子量: 318.723
• InChiKey: AGJBKFAPBKOEGA-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -0.65
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  49.4
• 氢给体数：
  0
• 氢受体数：
  3

ADMET

代谢

在大鼠中，乙酸甲氧基乙基汞部分降解为无机汞离子。

/In rats, methoxyethylmercuric acetate is/ partly degraded to inorganic mercury ions.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

乙酸甲氧基乙基汞在组织培养中对兔视网膜极为有毒，在5×10^-6摩尔浓度下，4小时内导致细胞普遍破坏。

Methoxyethyl mercuric acetate has been found very toxic to rabbit retina in tissue culture, at concn of 5X10-6 molar causing general destruction of the cells in 4 hours.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

甲氧基乙基汞醋酸酯和可能甲氧基乙基氯化汞在高浓度应用于皮肤时是发疱剂...系统中毒的症状被认为与氯化汞引起的症状相似。

The /methoxyethylmercuric/ acetate & presumably the /methoxyethylmercuric/ chloride are vesicants when applied to the skin in high concn. ... The signs & symptoms of systemic poisoning are believed to resemble those induced by mercuric chloride.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

在鲤鱼肝胰腺中，研究了喂食添加了27 ppm甲氧基乙基汞醋酸的影响。实验在第7、14和21天进行，对肝胰腺进行了与组化活性相关的非特异性酯酶、碱性磷酸酶、酸性磷酸酶、乳酸脱氢酶和NADH2偶联酶的分析。非特异性酯酶的活性在第14天实验时降低，并保持同一水平直到实验结束。碱性磷酸酶活性的降低未观察到直到第21天实验，而酸性磷酸酶活性在第7天和第14天上升，在第21天时与对照 group 相似。在实验 group 中，葡萄糖-6-磷酸酶活性在第7天下降，乳酸脱氢酶活性在第14天实验时下降。NADH2-偶联酶活性在整个实验过程中与对照 group 的值相比没有显著变化。

In the carp hepatopancreas the effect of feeding with the added 27 ppm methoxyethylmercuric acetate was investigated. The fishes were sacrificed on the experimental days 7, 14, and 21, and the analysis of the hepatopancreas related to the histochemical activity of non-specific esterases, alkaline and acid phosphatase, lactic acid dehydrogenase, and NADH2 diaphorase. The activity of non-specific esterases decreased on the 14th experimental day and remained on the same level up to the end of the experiment. A decrease of the activity of alkaline phosphatase was not observed until the 21st experimental day, whereas the activity of acid phosphatase went up on the 7th and 14th experimental days, and on the 21st day it resembled that observed in the control group. In the experimental group the activity of glucose-6-phosphatase went down on the 7th day and the activity of lactic acid dehydrogenase on the 14th experimental day. The activity of NADH2-diaphorase did not significantly change in relation to the values in the control group throughout the entire experiment.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

这项工作的目的是研究草鱼（Cyprinus carpio L.）可能由于接触用作杀菌剂的甲基乙汞醋酸而引起的血液学变化。实验组的鱼在三个星期内通过饲料接触了该物质。实验组总淋巴细胞数在第7天已经减少（p < 0.01），并且在整个实验期间几乎保持同一水平，但显著低于对照组。实验组的小淋巴细胞数量也在实验第7天减少（p < 0.01），并且减少趋势一直持续到实验结束。大淋巴细胞数量在实验第7天增加（p < 0.01），并且增加趋势一直持续到实验结束。大淋巴细胞群体表现出细胞病理学变化，形式为细胞质空泡和细胞质突起。这些变化的发生频率随着实验的进行而增加。

The purpose of this work was to study possible hematological changes in carp (Cyprinus carpio L.) which might be induced by the experimental poisoning with metoxyethylmercury acetate which is used as fungicide. The experimental group of fishes was exposed to the named substance which was mixed with the feed during three weeks. The total lymphocytes number decreased in experimental group already at 7th day (p < 0.01), and remained almost at the same level, but considerably lower than the experimental group, until the end of the experiment. The number of small lymphocytes in the experimental group decreased also at the 7th day of the experiment (p < 0.01), and the decreasing tendency continued up to the end of the experiment. The number of large lymphocytes increased at the day 7th of the experiment (p < 0.01), and the increasing tendency continued until the end of the experiment. The population of large lymphocytes showed the cytopathological changes in the form of cytoplasmic vacuoles and cytoplasmic shoots. The frequency of these changes increased through the experiments.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性值

大鼠口服LD50 25毫克/千克

LD50 Rat oral 25 mg/kg

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为反应物：
  描述：

  醋酸甲氧基乙基汞 、 alkaline earth salt of/the/ methylsulfuric acid 生成 乙烯
  参考文献：
  名称：

  Schoeller; Schrauth; Essers, Chemische Berichte, 1913, vol. 46, p. 2866,2868

  摘要：

  DOI：
• 作为产物：
  描述：

  乙烯 、 mercury(II) diacetate 在 甲醇 作用下， 生成 醋酸甲氧基乙基汞
  参考文献：
  名称：

  Mono and Disubstituted Organo-Mercury Derivatives of Acetylene

  摘要：

  DOI：

  10.1021/ja01336a043

文献信息

• HUTCHINSON, P. J.
  作者：HUTCHINSON, P. J.

  DOI：——

  日期：——