4-bromo-1-(4-fluorophenyl)-7,9-dimethyl-2-oxa-3,7,9-triaza-spiro[4.5]dec-3-ene-6,8,10-trione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-bromo-1-(4-fluorophenyl)-7,9-dimethyl-2-oxa-3,7,9-triaza-spiro[4.5]dec-3-ene-6,8,10-trione
• 英文别名: 4-Bromo-1-(4-fluorophenyl)-7,9-dimethyl-2-oxa-3,7,9-triazaspiro[4.5]dec-3-ene-6,8,10-trione；4-bromo-1-(4-fluorophenyl)-7,9-dimethyl-2-oxa-3,7,9-triazaspiro[4.5]dec-3-ene-6,8,10-trione
• 化学式: C₁₄H₁₁BrFN₃O₄
• 分子量: 384.161
• InChiKey: FENJEULPGNMGGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  23
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  79.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  1,1-二溴甲醛肟 、 5-(4-fluorobenzylidene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione 在 potassium hydrogencarbonate 作用下， 以 四氢呋喃 为溶剂， 反应 24.0h， 以80%的产率得到4-bromo-1-(4-fluorophenyl)-7,9-dimethyl-2-oxa-3,7,9-triaza-spiro[4.5]dec-3-ene-6,8,10-trione
  参考文献：
  名称：

  Synthesis of spiro 3-bromo-4,5-dihydroisoxazoles via [1,3]dipolar cycloaddition reactions

  摘要：

  A group of novel 4-bromo-7,9-dimethyl-1-aryl-2-oxa-3,7,9-triaza-spiro[4.5]dec-3-ene-6,8,10-trione derivatives is prepared through 1,3-dipolar cycloadditions between benzylidenes and bromonitrile oxide. This reaction is shown to have high atom economy. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.02.006

文献信息

• Synthesis of spiro 3-bromo-4,5-dihydroisoxazoles via [1,3]dipolar cycloaddition reactions
  作者：Ebrahim Soleimani、Hossein Yazdani、Parisa Saei

  DOI：10.1016/j.tetlet.2015.02.006

  日期：2015.3

  A group of novel 4-bromo-7,9-dimethyl-1-aryl-2-oxa-3,7,9-triaza-spiro[4.5]dec-3-ene-6,8,10-trione derivatives is prepared through 1,3-dipolar cycloadditions between benzylidenes and bromonitrile oxide. This reaction is shown to have high atom economy. (C) 2015 Elsevier Ltd. All rights reserved.