(3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate;methanesulfonic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: (3R)-3-hydroxy-4-(trimethylazaniumyl)butanoate;methanesulfonic acid
• 化学式: C8H19NO6S
• 分子量: 257.31
• InChiKey: HYSXNCIJGNMNAS-FYZOBXCZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.31
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  123
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Methods and compositions for treating obesity, preventing weight gain, promoting weight loss, promoting slimming, or treating or preventing the development of diabetes
  申请人：NAN Global, LLC

  公开号：US10849872B2

  公开（公告）日：2020-12-01

  The present invention relates to compositions and kits including a chemical uncoupler, such as tyrphostin 9 or precursor or a salt thereof, and compositions including a chemical uncoupler, such as tyrphostin 9 in combination with one or more therapeutic agents, for example, L-carnitine, which are useful, for example, in treating obesity, preventing weight gain, promoting weight loss/slimming, and/or treating or preventing the development of diabetes.

  本发明涉及包括化学解偶联剂的组合物和试剂盒，如tyrphostin 9或其前体或盐，以及包括化学解偶联剂的组合物，如tyrphostin 9与一种或多种治疗剂（例如左旋肉碱）的组合物，这些组合物在治疗肥胖症、防止体重增加、促进减肥/瘦身和/或治疗或预防糖尿病发展等方面有用。
• Ultrafine L-carnitine, methods of preparing the same, compositions containing the same, and methods of using the same
  申请人：Sigma-Tau HealthScience S.p.A.

  公开号：US20020111383A1

  公开（公告）日：2002-08-15

  L-carnitine which has a particle size such that it substantially passes through a 100 USBS mesh sieve exhibits an increased bioavailability, a decreased hygroscopicity, and may be conveniently formulated with oil-based materials.

  L-carnitine 的粒度基本上可以通过 100 USBS 的筛网，生物利用度提高，吸湿性降低，并且可以方便地与油基材料一起配制。
• Ultrafine-L-carnitine, methods of preparing the same, compositions containing the same, and methods of using the same
  申请人：Hassen Ken

  公开号：US20050124558A1

  公开（公告）日：2005-06-09

  L-carnitine which has a particle size such that it substantially passes through a 100 USBS mesh sieve exhibits an increased bioavailability, a decreased hygroscopicity, and may be conveniently formulated with oil-based materials.

  L-carnitine 的粒度基本上可以通过 100 USBS 的筛网，生物利用度提高，吸湿性降低，并且可以方便地与油基材料一起配制。
• ULTRAFINE L-CARNITINE, METHODS OF PREPARING THE SAME, COMPOSITIONS CONTAINING THE SAME, AND METHODS OF USING THE SAME
  申请人：Sigma-Tau Healthscience S.p.A.

  公开号：EP1218001A1

  公开（公告）日：2002-07-03
• EP1218001A4
  申请人：——

  公开号：EP1218001A4

  公开（公告）日：2005-05-18