3-(4-methoxy-phenyl)-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-propionitrile

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-(4-methoxy-phenyl)-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-propionitrile
• 英文别名: 3-(4-methoxyphenyl)-2-((2,2,6,6-tetramethylpiperidin-1-yl)oxy)propanenitrile；3-(4-Methoxyphenyl)-2-(2,2,6,6-tetramethylpiperidin-1-yl)oxypropanenitrile；3-(4-methoxyphenyl)-2-(2,2,6,6-tetramethylpiperidin-1-yl)oxypropanenitrile
• 化学式: C₁₉H₂₈N₂O₂
• 分子量: 316.444
• InChiKey: SNGAOZCFPRWZTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  45.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,2,6,6-四甲基哌啶氧化物 、 4-甲氧基苯硼酸 、 丙烯腈 在 dipotassium peroxodisulfate 、 silver nitrate 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 1.5h， 以50%的产率得到3-(4-methoxy-phenyl)-2-(2,2,6,6-tetramethyl-piperidin-1-yloxy)-propionitrile
  参考文献：
  名称：

  Practical Radical Cyclizations with Arylboronic Acids and Trifluoroborates

  摘要：

  Practical radical cyclizations using organoboronic acids and trifluoroborates take place in water, open to air, and In a scalable fashion employing catalytic silver nitrate and stoichiometric potassium persulfate. Both Pschorr-type cyclizations and tandem radical cyclization/trap cascades are described, Illustrating the utility of these mild conditions for the generation of polycyclic scaffolds.

  DOI：

  10.1021/ol2023505

文献信息

• Intermolecular Radical Carboaminohydroxylation of Olefins with Aryl Diazonium Salts and TEMPO
  作者：Markus R. Heinrich、Alexander Wetzel、Marcel Kirschstein

  DOI：10.1021/ol701622d

  日期：2007.9.1

  Highly reactive aryl radicals can selectively be reacted with a broad variety of activated and nonactivated olefinic substrates in the presence of nitroxyl radicals. Direct recombination of the aryl radical and the nitroxide as well as telomerization of the olefin is successfully suppressed by the reaction conditions.
• Practical Radical Cyclizations with Arylboronic Acids and Trifluoroborates
  作者：Jonathan W. Lockner、Darryl D. Dixon、Rune Risgaard、Phil S. Baran

  DOI：10.1021/ol2023505

  日期：2011.10.21

  Practical radical cyclizations using organoboronic acids and trifluoroborates take place in water, open to air, and In a scalable fashion employing catalytic silver nitrate and stoichiometric potassium persulfate. Both Pschorr-type cyclizations and tandem radical cyclization/trap cascades are described, Illustrating the utility of these mild conditions for the generation of polycyclic scaffolds.