1,2-dihydroxycyclohexa-3,5-diene-1,4-dicarboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 1,2-dihydroxycyclohexa-3,5-diene-1,4-dicarboxylic acid
• 英文别名: 3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylic acid
• 化学式: C₈H₈O₆
• 分子量: 200.148
• InChiKey: UKFMEOHAOCKDOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,2-dihydroxycyclohexa-3,5-diene-1,4-dicarboxylic acid 在 sodium hydroxide 作用下， 以 硫酸 为溶剂， 反应 1.0h， 以to yield 2-hydroxybenzene-1,4-dicarboxylic acid的产率得到2-羟基对苯二甲酸
  参考文献：
  名称：

  Process for the preparation of hydroxyterephthalic acid

  摘要：

  1,2-二羟基环己-3,5-二烯-1,4-二羧酸及其盐是一种新的中间体，通过脱水反应可以得到羟基对苯二甲酸。可以通过培养能够氧化对苯二甲酸但无法降解由此形成的1,2-二羟基环己-3,5-二烯-1,4-二羧酸的微生物，与对苯二甲酸和碳/能源源共同制备。

  公开号：

  US05124479A1

文献信息

• Hydroxyterephthalic acid
  申请人：Celgene Corporation

  公开号：US05068414A1

  公开（公告）日：1991-11-26

  1,2-Dihydroxycyclohexa-3,5-diene-1,4-dicarboxylic acid and its salts, which are novel intermediates yielding hydroxyterephthalic acid upon dehydration, can be prepared by culturing terephthalic acid and a carbon/energy source with a microorganism capable of oxidizing terephthalic acid but incapable of degradation of 1,2-dihydroxycyclohexa-3,5-diene-1,4-dicarboxylic acid thereby formed.

  1,2-二羟基环己-3,5-二烯-1,4-二羧酸及其盐是一种新型中间体，通过脱水反应可产生羟基对苯二甲酸。可以通过利用一种能氧化对苯二甲酸但不能降解由此形成的1,2-二羟基环己-3,5-二烯-1,4-二羧酸的微生物，培养对苯二甲酸和碳源/能源来制备。
• HIV INTEGRASE INHIBITORS
  申请人：National Institutes of Health

  公开号：US20140142137A1

  公开（公告）日：2014-05-22

  Provided herein, inter alia, are novel compounds for the inhibition of HIV integrase. The compounds disclosed herein are useful for methods of treating HIV infection in a subject in need thereof.

  本文提供了一些新的化合物，用于抑制HIV整合酶。本文所披露的化合物可用于治疗需要治疗HIV感染的人体内的方法。
• GENE-DISRUPTED STRAIN, RECOMBINANT PLASMID, TRANSFORMANT AND METHOD OF PRODUCING 3-CARBOXYMUCONOLACTONE
  申请人：KABUSHIKI KAISHA TOYOTA JIDOSHOKKI

  公开号：EP2147973A1

  公开（公告）日：2010-01-27

  Industrial-scale fermentative production of 3-carboxy-cis,cis-muconic acid from terephthalic acid. Also, a protocatechuate 4,5-ring-cleaving enzyme gene-disrupted strain in which the gene coding for (a) the amino acid sequence set forth in SEQ ID NO: 1 or 3, or (b) the amino acid sequence set forth in SEQ ID NO: 1 or 3 which has a deletion, substitution, addition and/or insertion of one or more amino acids and exhibits protocatechuate 4,5-ring cleavage activity, present in the chromosomal DNA of microbial cells, has been disrupted; recombinant plasmids comprising the Tph gene and protocatechuate 3,4-dioxygenase gene; transformants obtained by introducing the recombinant plasmids into the disrupted strain; and a process for production of 3-carboxy-cis,cis-muconic acid and/or 3-carboxymuconolactone characterized by culturing the transformants in the presence of terephthalic acid.

  以对苯二甲酸为原料，工业规模发酵生产 3-羧基-顺式、顺式-粘液酸。 另外，一种原儿茶酸 4,5-环裂解酶基因缺失菌株，其中编码(a) SEQ ID NO: 1 或 3 所列氨基酸序列，或(b) SEQ ID NO：1 或 3 所列的氨基酸序列，该序列具有一个或多个氨基酸的缺失、替代、添加和/或插入，并具有原儿茶酸 4,5 环裂解活性，存在于微生物细胞的染色体 DNA 中；重组质粒，包含 Tph 基因和原儿茶酸 3,4 二加氧酶基因；通过将重组质粒导入被破坏的菌株而获得的转化子；以及一种生产 3-羧基-顺式、顺式-黏菌素酸和/或 3-羧基黏菌素内酯的工艺，其特征在于在对苯二甲酸存在下培养转化子。
• JP2002345459A
  申请人：——

  公开号：JP2002345459A

  公开（公告）日：2002-12-03
• GENE-DISRUPTED STRAIN, RECOMBINANT PLASMIDS, TRANSFORMANTS AND PROCESS FOR PRODUCTION OF 3-CARBOXYMUCONOLACTONE
  申请人：Shimo Toshihisa

  公开号：US20100209978A1

  公开（公告）日：2010-08-19

  Industrial-scale fermentative production of 3-carboxy-cis,cis-muconic acid from terephthalic acid. Also, a protocatechuate 4,5-ring-cleaving enzyme gene-disrupted strain in which the gene coding for (a) the amino acid sequence set forth in SEQ ID NO: 1 or 3, or (b) the amino acid sequence set forth in SEQ ID NO: 1 or 3 which has a deletion, substitution, addition and/or insertion of one or more amino acids and exhibits protocatechuate 4,5-ring cleavage activity, present in the chromosomal DNA of microbial cells, has been disrupted; recombinant plasmids comprising the Tph gene and protocatechuate 3,4-dioxygenase gene; transformants obtained by introducing the recombinant plasmids into the disrupted strain; and a process for production of 3-carboxy-cis,cis-muconic acid and/or 3-carboxymuconolactone characterized by culturing the transformants in the presence of terephthalic acid.