Propionic acid propionyloxymethyldisulfanylmethyl ester

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Propionic acid propionyloxymethyldisulfanylmethyl ester
• 英文别名: Bis(propionyloxymethyl)disulfide；(propanoyloxymethyldisulfanyl)methyl propanoate
• 化学式: C₈H₁₄O₄S₂
• 分子量: 238.329
• InChiKey: QPNAKAXLLBYMOV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  103
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  sodium 4-methylbenzenesulfinate 、 Propionic acid propionyloxymethyldisulfanylmethyl ester 以 水 、 丙酮 为溶剂， 反应 2.0h， 以31%的产率得到1-p-toluenesulfonyl-4-propionoxy-2,3-dithiabutane
  参考文献：
  名称：

  摘要：

  Recently developed synthetic methodology has been exploited for the preparation of an assortment of alpha,alpha'-disubstituted disulfides including all three linkage isomeric types of alpha,alpha'-diester dimethyl disulfides. Two of the diesters are very powerful antifungal agents against Aspergillus niger and Aspergillus flavus. An alpha -ester alpha'-sulfone disulfide is the most powerful fungitoxin developed by this ongoing research effort.

  DOI：

  10.1071/ch01046
• 作为产物：
  描述：

  丙酸 、 2,3-dithiabutylpropionate 在 potassium permanganate 作用下， 反应 1.0h， 以19%的产率得到Propionic acid propionyloxymethyldisulfanylmethyl ester
  参考文献：
  名称：

  摘要：

  Recently developed synthetic methodology has been exploited for the preparation of an assortment of alpha,alpha'-disubstituted disulfides including all three linkage isomeric types of alpha,alpha'-diester dimethyl disulfides. Two of the diesters are very powerful antifungal agents against Aspergillus niger and Aspergillus flavus. An alpha -ester alpha'-sulfone disulfide is the most powerful fungitoxin developed by this ongoing research effort.

  DOI：

  10.1071/ch01046

文献信息

• Sulfurizing reagents and their use for oligonucleotides synthesis
  申请人：MAZUR Wieslaw Adam

  公开号：US20120071640A1

  公开（公告）日：2012-03-22

  An oligonucleotide which comprises at least one internucleotide linkage comprising a P—S—R bond and at least two nucleosides, wherein R corresponds to the formula (I) wherein A is a geminally substituted alkylene group, preferably CH 2 , X and Y are independently selected from S and O, and R 0 is selected from the group consisting of optionally substituted carbon bonded organic residue, such as in particular optionally substituted alkyl or aryl, SRx, ORx and NRxRy wherein Rx and/or Ry are selected from H and organic residues and at least Rx is a substituent other than H. Another object of the invention is a sulfurizing agent useful for oligonucleotide manufacture and the manufacture thereof. Other nucleotides described comprise at least one internucleotide linkage comprising a P—S—R bond, at least one internucleotide linkage comprising a P—S—R′ bond and at least three nucleosides wherein R′ is an organic residue other than the group R, preferably selected from a group consisting of an aryl group and a heteroaryl group which is bonded to the S-atom through an annular carbon atom.

  该发明涉及一种寡核苷酸，其中至少包括一种由P-S-R键组成的核苷酸连接，以及至少两个核苷酸。其中，R对应于公式(I)，其中A是一个双重取代的烷基，优选为CH2，X和Y分别选择自S和O，R0选择自一组由可选取代的碳键合有机残基组成，特别是可选取代的烷基或芳基，SRx、ORx和NRxRy，其中Rx和/或Ry选择自H和有机残基，至少Rx是除H之外的取代基。该发明的另一个目的是用于寡核苷酸制备的硫化剂及其制备方法。其他核苷酸至少包括一种由P-S-R键组成的核苷酸连接，至少包括一种由P-S-R'键组成的核苷酸连接，以及至少三个核苷酸，其中R'是除R之外的有机残基，优选选择自一个芳基和一个杂环芳基，该芳基或杂环芳基通过环状碳原子与S原子键合。
• SULFURIZING REAGENTS AND THEIR USE FOR OLIGONUCLEOTIDES SYNTHESIS
  申请人：Girindus America, Inc.

  公开号：EP2382227A1

  公开（公告）日：2011-11-02
• [EN] SULFURIZING REAGENTS AND THEIR USE FOR OLIGONUCLEOTIDES SYNTHESIS<br/>[FR] RÉACTIFS DE SULFURISATION ET LEUR UTILISATION POUR LA SYNTHÈSE D'OLIGONUCLÉOTIDES
  申请人：GIRINDUS AMERICA INC

  公开号：WO2010072831A1

  公开（公告）日：2010-07-01

  An oligonucleotide which comprises at least one internucleotide linkage comprising a P-S-R bond and at least two nucleosides, wherein R corresponds to the formula (I) wherein A is a geminally substituted alkylene group, preferably CH2, X and Y are independently selected from S and O, and R0 is selected from the group consisting of optionally substituted carbon bonded organic residue, such as in particular optionally substituted alkyl or aryl, SRx, ORx and NRxRy wherein Rx and/or Ry are selected from H and organic residues and at least Rx is a substituent other than H. Another object of the invention is a sulfurizing agent useful for oligonucleotide manufacture and the manufacture thereof.