8-[[3-(1H-indol-3-yl)propylamino]methyl]-1,3,7,8-tetrahydro-[1,4]dioxino[2,3-e]benzimidazol-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 8-[[3-(1H-indol-3-yl)propylamino]methyl]-1,3,7,8-tetrahydro-[1,4]dioxino[2,3-e]benzimidazol-2-one
• 化学式: C₂₁H₂₂N₄O₃
• 分子量: 378.4
• InChiKey: KMWAQGHBMHNOTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  28
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  87.4
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• Antipsychotic aminomethyl derivatives of 1,3,7,8-tetrahydro-6,9-dioxa-1,3-diaza-cyclopenta[a]-naphthalen-2-one
  申请人：Wyeth

  公开号：US20030045526A1

  公开（公告）日：2003-03-06

  Compounds of the formula: 1 useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced pychoses and dyskinesias, Tourette's syndrome and hyperprolactinemia and in the treatment of drug addiction such as the addiction to ethanol, nicotine or cocaine and related illnesses.

  该公式化合物用于治疗多巴胺系统紊乱，如精神分裂症、情感性精神分裂症、双相情感障碍、帕金森病、L-多巴诱导的精神病和运动障碍、图雷特综合症、高泌乳素血症以及药物成瘾，如对乙醇、尼古丁或可卡因的成瘾以及相关疾病的治疗。
• US6861434B2
  申请人：——

  公开号：US6861434B2

  公开（公告）日：2005-03-01
• [EN] ANTIPSYCHOTIC AMINOMETHYL DERIVATIVES OF 1,3,7,8-TETRAHYDRO-6,9-DIOXA-1,3-DIAZA-CYCLOPENTA[A]-NAPHTHALEN-2-ONE<br/>[FR] DERIVES AMINOETHYLE ANTIPSYCHOTIQUES DE 1,3,7,8-TETRAHYDRO-6,9-DIOXA-1,3-DIAZA-CYCLOPENTA[A]-NAPHTHALEN-2-ONE
  申请人：WYETH CORP

  公开号：WO2002088134A2

  公开（公告）日：2002-11-07

  Compounds of the formula (I), useful for treatment of disorders of the dopaminergic system, such as schizophrenia, schizoaffective disorder, bipolar disorder, Parkinson's disease, L-DOPA induced psychoses and dyskinesias, Tourette's syndrome and hyperprolactinemia and in the treatment of drug addiction such as the addiction to ethanol, nicotine or cocaine and related illnesses.