1-butyl-7-hydroxy-4-methyl-2,4,4a,9,10,10a-hexahydro-1H-phenanthren-3-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: 1-butyl-7-hydroxy-4-methyl-2,4,4a,9,10,10a-hexahydro-1H-phenanthren-3-one
• 化学式: C₁₉H₂₆O₂
• 分子量: 286.4
• InChiKey: HLMGLKRYDQZQOI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• [EN] NOVEL ESTROGEN RECEPTOR LIGANDS AND METHODS I<br/>[FR] NOUVEAUX LIGANDS DE RECEPTEURS D'OESTROGENES ET PROCEDES I
  申请人：KAROBIO AB

  公开号：WO2002053522A2

  公开（公告）日：2002-07-11

  The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant inventive are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including bone loss, bone fractures, osteoporosis, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, cerebral degenerative disorders, restinosis, gynecomastia, autoimmune disease, vascular smooth muscle cell proliferation, obesity, incontinence, and cancer of the lung, colon, breast, uterus, and prostate.