2,2,2-trichloroethyl 2-(4-fluorophenyl)aziridine-1-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 2,2,2-trichloroethyl 2-(4-fluorophenyl)aziridine-1-carboxylate
• 英文别名: 2,2,2-Trichloroethyl 2-(4-fluorophenyl)aziridine-1-carboxylate
• 化学式: C₁₁H₉Cl₃FNO₂
• 分子量: 312.555
• InChiKey: WTDNRDRDZINDIF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  29.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,2,2-trichloroethyl N-tosyloxycarbamate 、 4-氟苯乙烯 在 potassium carbonate 作用下， 以 苯 为溶剂， 以55%的产率得到2,2,2-trichloroethyl 2-(4-fluorophenyl)aziridine-1-carboxylate
  参考文献：
  名称：

  Copper-Catalyzed Alkene Aziridination with N-Tosyloxycarbamates

  摘要：

  Pyridine copper complexes were found as active catalysts for the intramolecular aziridination of allylic N-tosyloxycarbamates and the intermolecular aziridination of styrenes with trichloroethyl N-tosyloxycarbamates. Free aziridines were easily obtained by basic deprotection of the trichloroethyl group.

  DOI：

  10.1021/ol702152e

文献信息

• Copper-Catalyzed Alkene Aziridination with <i>N</i>-Tosyloxycarbamates
  作者：Hélène Lebel、Sylvain Lectard、Michaël Parmentier

  DOI：10.1021/ol702152e

  日期：2007.11.1

  Pyridine copper complexes were found as active catalysts for the intramolecular aziridination of allylic N-tosyloxycarbamates and the intermolecular aziridination of styrenes with trichloroethyl N-tosyloxycarbamates. Free aziridines were easily obtained by basic deprotection of the trichloroethyl group.